Near Infrared Fluorescent Single Walled Carbon Nanotubes as Novel Solution Phase Optical Sensing Materials Proposal Renewal

近红外荧光单壁碳纳米管作为新型溶液相光学传感材料提案更新

• 批准号: 1213622
• 负责人: Michael Strano
• 金额: $ 40万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213622&HistoricalAwards=false
• 关键词: Near; Infrared; Fluorescent; Single; Walled

With support from the Chemical Measurement and Imaging (CMI) and Macromolecular, Supramolecular, and Nanochemistry (MSN) Programs in the Division of Chemistry, Professor Michael Strano at Massachusetts Institute of Technology and his group will develop new chemical tools to recognize and communicate the binding of molecules to the nanotube interface using non-covalent approaches. Specifically, the investigator plans to 1) study several molecular recognition interactions through structure/property relationships of absorbed amphiphilic polymer; 2) construct a visible/near infrared dual channel single molecule imaging microscope to study molecular recognition at the nanotube surface; 3) synthesize new polymeric recognition sites based on an amphiphilic loop structure as a means of molecular recognition, such as boronic acid-poly ethylene glycol polymer brushes and a looped PEG motif; and 4) explore variants of a Ni2+ chelator-based protein recognition approach to extend to glycoprotein detection and profiling. The proposed research, if successful, will advance understanding about how chemical interfaces at the carbon nanotube surface influence exciton radiative recombination, and the learned knowledge will impact biosensing, bioimaging, as well fields beyond life science research. In addition to engaging undergraduate students in research and education, Professor Strano also proposes to disseminate research results through public media and continuously collaborate with a high school teach to broaden impacts at the K-12 level.

在化学系化学测量和成像 (CMI) 以及高分子、超分子和纳米化学 (MSN) 项目的支持下，麻省理工学院的 Michael Strano 教授和他的团队将开发新的化学工具，以使用非共价方法识别和传达分子与纳米管界面的结合。 具体来说，研究人员计划1）通过吸收的两亲性聚合物的结构/性质关系研究几种分子识别相互作用； 2）构建可见光/近红外双通道单分子成像显微镜，研究纳米管表面的分子识别； 3）基于两亲环结构合成新的聚合物识别位点作为分子识别的手段，例如硼酸-聚乙二醇聚合物刷和环PEG基序； 4) 探索基于 Ni2+ 螯合剂的蛋白质识别方法的变体，以扩展到糖蛋白检测和分析。 拟议的研究如果成功，将加深对碳纳米管表面化学界面如何影响激子辐射复合的理解，所学到的知识将影响生物传感、生物成像以及生命科学研究以外的领域。 除了让本科生参与研究和教育外，斯特拉诺教授还建议通过公共媒体传播研究成果，并不断与高中教师合作，扩大 K-12 层面的影响。