RUI-Collaborative Research-Electrokinetic Transport and Electric Field Control of Ion Motion through the Interior of Single-Walled Carbon Nanotubes
RUI-合作研究-单壁碳纳米管内部离子运动的电动输运和电场控制
基本信息
- 批准号:1904453
- 负责人:
- 金额:$ 5.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Dr. Mark Ellison of the Department of Chemistry, Ursinus College and Dr. Michael S. Strano of the Department of Chemical Engineering, Massachusetts Institute of Technology (MIT) are supported by the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry to study the motion of ions and molecules through the interior of carbon nanotubes. Flow of material at these dimensions is quite different from our everyday experience, so this research is expected to improve our understanding of how these ions and molecules are transported through tubes that are not much bigger in diameter than the objects themselves. The work is initially focused on the transport of amino acids and neurotransmitters, including acetylcholine and dopamine through the nanotubes. At a later stage, the nanotubes are outfitted with tiny gold electrodes to control the rate of flow through the tubes using an electric signal. If successful, the project is likely to impact the development of biosensing, medical testing, and electronic nanodevices. It is also likely to improve our understanding of the motion of biologically important molecules in biological channels and synthetic nanopores such as in the human brain. During the course of conducting this research, a diverse group of undergraduate students as well as female high school students are afforded a research experience at Ursinus College. In addition, the students benefit from visits to MIT to prepare nanotube devices and conduct experiments with the help of MIT graduate students. The project investigates the fundamental processes of the transport of small ions and molecules through single wall nanotubes (SWNTs). Chemical vapor deposition (CVD) is used to deposit SWNTs on silicon wafers and the devices are equipped with electrodes to conduct the needed ion current measurements. This, combined with SEM and Raman spectroscopy measurements, provides the necessary data to characterize the devices and to provide information on the mechanisms involved in the transport of ionic and molecular species through the nanotubes. The Ursinus undergraduate students travel to MIT to use equipment and instruments such as a chemical vapor deposition oven, scanning electron microscope, and a Raman microscope to construct the SWNT devices. The devices are brought back to Ursinus to conduct the voltage clamp measurements of ion transport. The work is initially focused on the transport of amino acids and neurotransmitters, including acetylcholine and dopamine, through the nanotubes. At a later stage, the nanotubes are outfitted with gold electrodes to gate and control the rate of flow through the tubes by an electric signal. The experiments are designed to provide the data needed to improve our understanding of ion and molecule transport through SWCNT nanopores and to explore the use of SWCNTs as conduits for the delivery of amino acids and neurotransmitters to specific targets.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
乌尔西诺学院化学系的马克·埃里森博士和麻省理工学院化学工程系的迈克尔·s·斯特拉诺博士在化学系的大分子、超分子和纳米化学(MSN)项目的支持下,研究了离子和分子通过碳纳米管内部的运动。在这些维度上的物质流动与我们的日常经验大不相同,因此这项研究有望提高我们对这些离子和分子如何通过直径比物体本身大不了多少的管道运输的理解。这项工作最初的重点是氨基酸和神经递质,包括乙酰胆碱和多巴胺通过纳米管的运输。在稍后的阶段,纳米管被装配上微小的金电极,用电信号来控制通过纳米管的流速。如果成功,该项目可能会影响生物传感、医学测试和电子纳米器件的发展。它也有可能提高我们对生物通道和合成纳米孔(如人脑)中生物重要分子运动的理解。在进行这项研究的过程中,一群不同的本科生以及女高中生在乌尔西诺斯学院获得了研究经验。此外,学生们还可以在麻省理工学院研究生的帮助下,参观麻省理工学院,制备纳米管器件并进行实验。该项目研究了小离子和分子通过单壁纳米管(SWNTs)传输的基本过程。化学气相沉积(CVD)用于在硅片上沉积swnt,器件配备电极以进行所需的离子电流测量。这与扫描电镜和拉曼光谱测量相结合,提供了表征器件的必要数据,并提供了离子和分子物种通过纳米管传输的机制的信息。乌尔西纳斯大学的本科生前往麻省理工学院,使用化学气相沉积炉、扫描电子显微镜和拉曼显微镜等设备和仪器来构建SWNT器件。这些设备被带回乌尔西诺进行离子传输的电压钳测量。这项工作最初集中在氨基酸和神经递质(包括乙酰胆碱和多巴胺)通过纳米管的运输上。在稍后的阶段,纳米管被装配上金电极,通过电信号来控制通过纳米管的流量。这些实验旨在提供所需的数据,以提高我们对通过SWCNTs纳米孔的离子和分子运输的理解,并探索SWCNTs作为将氨基酸和神经递质递送到特定靶点的管道的使用。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Strano其他文献
Saving the world with nanotechnology
用纳米技术拯救世界
- DOI:
10.1038/nnano.2006.113 - 发表时间:
2006-11-01 - 期刊:
- 影响因子:34.900
- 作者:
Donna J. Nelson;Michael Strano - 通讯作者:
Michael Strano
Michael Strano的其他文献
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{{ truncateString('Michael Strano', 18)}}的其他基金
Developing Nanosensor Chemical Cytometry (NCC) to Support the Development of Cellular Therapeutics
开发纳米传感器化学细胞术 (NCC) 以支持细胞治疗的发展
- 批准号:
2124194 - 财政年份:2021
- 资助金额:
$ 5.89万 - 项目类别:
Continuing Grant
Understanding Gas Transport through Nanopores in Graphene Membranes
了解石墨烯膜中纳米孔的气体传输
- 批准号:
1907716 - 财政年份:2019
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
EAGER: Detection Of In Vivo Corticosterone In Mice Using Cophmore Engineering And Fluorescent Carbon Nanotube Sensors
EAGER:使用 Cophmore 工程和荧光碳纳米管传感器检测小鼠体内皮质酮
- 批准号:
1445131 - 财政年份:2014
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
Collaborative Proposal:RUI: Single-Walled Carbon Nanotube Nanopores for Motion Control of Biologically Important Molecules and Ions and Undergraduate Training in Nanopore Transport
合作提案:RUI:用于生物重要分子和离子运动控制的单壁碳纳米管纳米孔以及纳米孔传输的本科生培训
- 批准号:
1306529 - 财政年份:2013
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
Near Infrared Fluorescent Single Walled Carbon Nanotubes as Novel Solution Phase Optical Sensing Materials Proposal Renewal
近红外荧光单壁碳纳米管作为新型溶液相光学传感材料提案更新
- 批准号:
1213622 - 财政年份:2012
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
EAGER: Continuous, Catalyzed Thermopower Wave Generators Powered by Renewable Biofuels: A New Fuel Cell Concept
EAGER:由可再生生物燃料驱动的连续催化热电波发生器:一种新的燃料电池概念
- 批准号:
1239073 - 财政年份:2012
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
Near Infrared Fluorescent Single Walled Carbon Nanotubes as Novel Solution Phase Optical Sensing Materials - Proposal Renewal
近红外荧光单壁碳纳米管作为新型溶液相光学传感材料 - 提案更新
- 批准号:
0753020 - 财政年份:2007
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
PECASE: Understanding and Exploiting the Surface Chemistry of Carbon Nanotubes: Optical Methods and Chemical Pathways for Manipulation, Control and Assembly at the Nanoscale
PECASE:理解和利用碳纳米管的表面化学:纳米尺度操纵、控制和组装的光学方法和化学途径
- 批准号:
0758352 - 财政年份:2007
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
NIRT: Single molecule detection in living cells using carbon nanotube optical probes
NIRT:使用碳纳米管光学探针进行活细胞中的单分子检测
- 批准号:
0753036 - 财政年份:2007
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
NIRT: Single molecule detection in living cells using carbon nanotube optical probes
NIRT:使用碳纳米管光学探针进行活细胞中的单分子检测
- 批准号:
0708459 - 财政年份:2007
- 资助金额:
$ 5.89万 - 项目类别:
Standard Grant
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