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Neurobiological and Psychological Reaction Patterns in Response to Social Rejection in BPD

BPD 患者对社会拒绝的神经生物学和心理反应模式

基本信息

批准号：
206454683
负责人：
Professor Dr. Martin Bohus
金额：
--
依托单位：
Klinik für Psychiatrie und Psychotherapie
依托单位国家：
德国
项目类别：
Clinical Research Units
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2018-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/206454683?language=en
关键词：
Neurobiological Psychological Reaction Patterns Response

项目摘要

The pervasive experience of social exclusion in BPD is assumed to contribute to severe interpersonal problems. In the first funding period, IP1 investigated potential mechanisms and behavioral consequences of the experience of social exclusion in this patient population. The findings suggest that the interpersonal problems seen in our sample were primarily linked to alterations not in the processing of real rejection, but rather to the processing of positive valent social signals, particularly in the domain of social inclusion and the sense of belonging. It appears that BPD patients are experiencing positive social cues as less intense; are less confident in evaluating such cues; feel less included in positive and neutral social encounters; expected less positive feedback from social co-players; fail to adjust their expectancies, particularly in the case of positive feedback; and react with a decrease in cooperative behavior to unknown others when previously included by social partners. The severity of many of these reactions was influenced by rejection sensitivity, which is a cognitive-affective disposition that is higher in individuals with BPD, even after remission of acute BPD symptoms. These distinct maladaptive mechanisms may result in a pervasive disruption of the sense of belonging, in feeling different and separated from others, and in feelings of loneliness. In the second funding period, IP1 will focus on two aims: a) applying the experimental findings of funding period 1 to a computer-based training intervention that will be evaluated in a randomized controlled trial; and b) further investigation of the patho-mechanisms of attenuated affiliation in BPD. We hypothesize that in BPD there is an impairment of basal affiliative processes such as behavioral matching (i.e., mimicry and synchronized action). We will study their interplay with sensitivity to social reward and altered expectations of events. Effects will be measured by means of overt behaviors, psychophysiological parameters (heart rate and electromyography), and neural correlates (fMRI).

BPD中普遍存在的社会排斥被认为是导致严重人际关系问题的原因。在第一个资助期内，IP 1调查了这一患者群体中社会排斥经历的潜在机制和行为后果。研究结果表明，在我们的样本中看到的人际关系问题主要与处理真实的拒绝的变化无关，而是与处理积极的社会信号有关，特别是在社会包容和归属感领域。BPD患者似乎正在经历积极的社会线索不那么强烈;在评估这些线索时不太自信;感觉不太包括在积极和中立的社会交往中;预期来自社会合作伙伴的积极反馈较少;未能调整他们的期望，特别是在积极反馈的情况下;并且当以前被社会伙伴包括时，对未知他人的合作行为减少。许多这些反应的严重程度受到排斥敏感性的影响，排斥敏感性是一种认知情感倾向，即使在急性BPD症状缓解后，BPD患者的认知情感倾向也较高。这些不同的适应不良机制可能导致归属感的普遍破坏，感觉与他人不同和分离，以及孤独感。在第二个资助期内，IP 1将集中于两个目标：a）将资助期1的实验结果应用于基于计算机的培训干预，并将在随机对照试验中进行评估;以及B）进一步研究BPD中关系减弱的病理机制。我们假设在BPD中存在基础亲和过程的损伤，例如行为匹配（即，模仿和同步动作）。我们将研究他们的相互作用与社会奖励的敏感性和改变预期的事件。将通过明显的行为、心理生理学参数（心率和肌电图）和神经相关因素（fMRI）来测量效果。