MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer (NMR)

阿巴拉契亚州立大学的Alexander Schwab教授及其同事Grant Holder、Nicole Bennett、Michael Ramey和Michael hamburg将获得一台400 MHz核磁共振光谱仪。该提案旨在加强各级的研究培训和教育，特别是在以下领域：(a)调查是否存在利用稳定ylides的Wittig反应的动力学微波效应；(b)生物膜中有机阴离子转运体的结构；(c)钴二（乙氧肟）配合物作为可逆制氢催化剂；(d)利用1H NMR和多变量分析对抗氧化原料进行代谢筛选；(e)多功能六苯基苯；(f)金属配位聚合物网络的模块化方法。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为阿巴拉契亚州立大学教学和研究的一个组成部分。

With this award from the Major Research Instrumentation Program, Professor Alexander Schwab from Appalachian State University and colleagues Grant Holder, Nicole Bennett, Michael Ramey and Michael Hambourger will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) investigation to probe whether there is a kinetic microwave effect utilizing the Wittig reaction of stabilized ylides; (b) structure of the organic anion transporter in biological membranes; (c) cobalt bis(glyoxime) complexes as reversible catalysts for hydrogen production; (d) metabolic screening of antioxidant-bearing raw materials using 1H NMR and multivariate analysis; (e) multifunctional hexaphenylbenzenes; and (f) modular approach to metal coordination polymer networks.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Appalachian State University.