MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Undergraduate and Faculty Research

通过这项来自主要研究仪器项目的奖励，来自Canisius学院的Mary O'Sullivan教授及其同事Mariusz Kozik、Timothy Gregg、Jeremy Steinbacher和Sarah Evans将获得一台400 MHz核磁共振光谱仪。该建议旨在加强各级的研究培训和教育，特别是在以下领域：(a)开发用于氟核磁共振成像的颗粒基造影剂；(b)有机机理和方法的研究（烯环丙烷化）；(c)寄生虫体内一种酶（锥虫硫酮还原酶）抑制剂的开发；(d)多胺与n -甲基- d -天冬氨酸（NMDA）受体相互作用的研究；(e) dna -蛋白交联的研究；(f)研究阐明无机配合物（过渡金属取代的杂多钨酸盐）的结构；(g)使用无机配合物作为光活化催化剂进行还原反应。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为卡尼修斯学院和邻近机构的教学和研究的一个组成部分。

With this award from the Major Research Instrumentation Program, Professor Mary O'Sullivan from Canisius College and colleagues Mariusz Kozik, Timothy Gregg, Jeremy Steinbacher and Sarah Evans will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) development of particle-based contrast agents for fluorine MRI; (b) investigations of organic mechanisms and methodologies (allene cyclopropanation); (c) development of inhibitors of an enzyme (trypanothione reductase) in parasites; (d) studies of the interactions of polyamines with the N-methyl-D-aspartate (NMDA) receptor; (e) investigations of DNA-protein cross-links; (f) studies to elucidate the structures of inorganic complexes (transition-metal substituted heteropolytungstates); and (g) uses of inorganic complexes as photo-activated catalysts for reduction reactions.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Canisius College and neighboring institutions.