MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Undergraduate and Faculty Research

MRI：购买 400 MHz NMR 波谱仪以加强本科生和教师研究

• 批准号: 1229021
• 负责人: Mary O'Sullivan
• 金额: $ 28.5万
• 依托单位: Canisius College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229021&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

With this award from the Major Research Instrumentation Program, Professor Mary O'Sullivan from Canisius College and colleagues Mariusz Kozik, Timothy Gregg, Jeremy Steinbacher and Sarah Evans will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) development of particle-based contrast agents for fluorine MRI; (b) investigations of organic mechanisms and methodologies (allene cyclopropanation); (c) development of inhibitors of an enzyme (trypanothione reductase) in parasites; (d) studies of the interactions of polyamines with the N-methyl-D-aspartate (NMDA) receptor; (e) investigations of DNA-protein cross-links; (f) studies to elucidate the structures of inorganic complexes (transition-metal substituted heteropolytungstates); and (g) uses of inorganic complexes as photo-activated catalysts for reduction reactions.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Canisius College and neighboring institutions.

有了这个主要研究仪器计划的奖项，来自Canisius学院的玛丽奥沙利文教授和同事Mariusz Kozik，Timothy Gregg，Jeremy Steinbacher和Sarah Evans将获得400 MHz NMR光谱仪。该提案旨在加强各级的研究、培训和教育，特别是在以下领域：（a）开发用于氟磁共振成像的颗粒造影剂;（B）研究有机机制和方法（丙二烯环丙烷化）;（c）开发酶的抑制剂（d）研究多胺与N-甲基-D-天冬氨酸（NMDA）受体的相互作用;（e）研究DNA-蛋白质交联;（f）研究无机配合物（过渡金属取代的杂多钨酸盐）的结构;及（g）利用无机配合物作为还原反应的光活化催化剂核磁共振光谱法是化学家用以阐明分子结构的最有力工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是教学的一个组成部分，以及在卡尼修斯学院和邻近机构的研究。