MRI: Acquisition of a Single Crystal X-Ray Diffractometer

由化学研究仪器和设施（CRIF）项目和多学科活动办公室（OMA）共同资助的主要研究仪器项目，塔夫茨大学的Arthur Utz教授及其同事Terry Haas、Elena rybakakakimova、Clay Bennett和Samuel Thomas将获得一台配备CCD探测器的单晶x射线衍射仪。该提案旨在加强各级的研究培训和教育，特别是在以下领域：(a)基于机制的选择性、高效、可切换的受体和氧化和其他小分子活化反应催化剂的设计；(b)功能性有机材料的设计；(c)为区域选择性和对映选择性合成方法设计和开发催化剂；(d)纳米材料和纳米催化剂设计；(e)含氟生物分子中的分子间相互作用和自组装；(f)功能高分子材料；(g)表面的单分子；(h)仿生蛋白基材料；(i)设计具有增强亲和力和选择性结合目标的环肽。x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器不仅将成为塔夫茨大学的教学和研究的组成部分，而且还将成为波士顿地区一系列主要本科院校的教学和研究的组成部分，包括布里奇沃特州立大学、伊曼纽尔学院和萨福克大学。目前正在计划向布伦特里高中的学生和聋哑本科生提供服务。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Office of Multidisciplinary Activities (OMA), Professor Arthur Utz from Tufts University and colleagues Terry Haas, Elena Rybak-Akimova, Clay Bennett and Samuel Thomas will acquire a single crystal X-ray diffractometer equipped with a CCD detector. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) mechanism-based design of selective, efficient, switchable receptors and catalysts for oxidations and other small molecule activation reactions; (b) design of functional organic materials; (c) design and development of catalysts for regioselective and enantioselective synthetic methods; (d) design of nanomaterials and nanocatalysts; (e) intermolecular interactions and self-assembly in fluorinated biomolecules; (f) functional polymer materials; (g) single molecules on surfaces; (h) biomimetic protein-based materials; and (i) design of cyclic peptides with enhanced affinity and selectivity of binding to their targets.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research not only at Tufts University but also in a series of Boston area primarily undergraduate institutions that include Bridgewater State University, Emmanuel College and Suffolk University. Outreach to Braintree High School students and to deaf undergraduate students is being planned.