MRI: Acquisition of a Single Crystal X-Ray Diffractometer

该奖项来自由化学研究仪器和设施（CRIF）计划和多学科活动办公室（OMA）共同资助的主要研究仪器计划，塔夫茨大学的亚瑟乌茨教授及其同事特里哈斯，埃琳娜Rybak-Akimova，克莱班尼特和塞缪尔托马斯将获得配备CCD探测器的单晶X射线衍射仪。该提案旨在加强各级的研究、培训和教育，特别是在以下领域：（a）以机制为基础设计用于氧化和其他小分子活化反应的选择性、高效、可转换受体和催化剂;（B）设计功能有机材料;（c）设计和开发用于区域选择性和对映选择性合成方法的催化剂;（d）设计纳米材料和纳米催化剂;（e）氟化生物分子中的分子间相互作用和自组装;（f）功能聚合物材料;（g）表面上的单分子;（h）仿生蛋白质材料;和（i）设计具有增强的与其靶结合的亲和力和选择性的环肽。X射线衍射仪允许精确和精确地测量分子的全部三维结构，包括键距和键角，并提供关于分子相对于相邻分子的空间排列的精确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器将成为教学和研究的一个组成部分，不仅在塔夫茨大学，而且在波士顿地区的一系列主要是本科院校，包括布里奇沃特州立大学，伊曼纽尔学院和萨福克大学。目前正在计划向布伦特里高中学生和聋人大学生进行宣传。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Office of Multidisciplinary Activities (OMA), Professor Arthur Utz from Tufts University and colleagues Terry Haas, Elena Rybak-Akimova, Clay Bennett and Samuel Thomas will acquire a single crystal X-ray diffractometer equipped with a CCD detector. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) mechanism-based design of selective, efficient, switchable receptors and catalysts for oxidations and other small molecule activation reactions; (b) design of functional organic materials; (c) design and development of catalysts for regioselective and enantioselective synthetic methods; (d) design of nanomaterials and nanocatalysts; (e) intermolecular interactions and self-assembly in fluorinated biomolecules; (f) functional polymer materials; (g) single molecules on surfaces; (h) biomimetic protein-based materials; and (i) design of cyclic peptides with enhanced affinity and selectivity of binding to their targets.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research not only at Tufts University but also in a series of Boston area primarily undergraduate institutions that include Bridgewater State University, Emmanuel College and Suffolk University. Outreach to Braintree High School students and to deaf undergraduate students is being planned.