Collaborative Research: Photonic and Electronic Devices Based on Self-Assembling DNA Templates

合作研究：基于自组装DNA模板的光子和电子器件

• 批准号: 1232239
• 负责人: Gleb Finkelstein
• 金额: $ 22.5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1232239&HistoricalAwards=false
• 关键词: Collaborative; Research; Photonic; Electronic; Devices

The objective of this program is to develop reliable protocols for fabricating functional photonic and electronic nanostructures using bioinspired, molecular assembly methods. In one of the proposed tasks, seed nanoparticles will be selectively attached through molecular recognition to the ?DNA origami? template and fused to form the electrodes; a separate nanoparticle island will be separately attached forming a single-electron transistor. In the other major task, plasmonic bow-tie antennae will be assembled from nanoparticles, and the optically active nanoscale object will be attached in the hot spot. The intellectual merit of the proposed project stems from the convergence of recent advances in DNA-based self-assembly methods with promising preliminary results on specific surface binding of solution-assembled complexes. These nanostructures may develop into a new class of naturally biocompatible sensors that will have transformative applications in the biomedical field. The broader impacts are the development of alternative, cheaper (most steps are in aqueous solution) and more versatile fabrication methods for making composite bio-nano-devices. The proposal has a strongly emphasized outreach component: the PIs plan to recruit MSc students from the North Carolina Central University ? a historically black university (HBCU). The program will train the students in the unique combination of biochemical and physical methods of modern nanotechnology that are relevant for both industrial and academic careers. Disadvantaged high school students (Project SEED) will participate during the summer months to get a feel for the emerging field of nanoscience.

该计划的目标是开发可靠的协议，用于制造功能性光子和电子纳米结构，使用生物启发，分子组装方法。在其中一个拟议的任务，种子纳米粒子将选择性地通过分子识别附着到？DNA折纸？模板并熔融以形成电极;单独的纳米颗粒岛将单独附着，形成单电子晶体管。在另一项主要任务中，等离子体领结天线将由纳米粒子组装而成，光学活性纳米级物体将附着在热点上。所提出的项目的智力价值源于最近的进展，在DNA为基础的自组装方法与有前途的初步结果的特定表面结合的溶液组装复合物的收敛。这些纳米结构可能会发展成为一类新的天然生物相容性传感器，在生物医学领域具有革命性的应用。更广泛的影响是开发替代的、更便宜的（大多数步骤是在水溶液中）和更通用的制造方法来制造复合生物纳米装置。该提案有一个非常强调的外展部分：PI计划从北卡罗来纳州中央大学招收硕士生？历史黑人大学（HBCU）该计划将培养学生在现代纳米技术的生物化学和物理方法的独特组合，这是相关的工业和学术生涯。dispersed高中学生（项目种子）将参加在夏季的几个月，以获得纳米科学的新兴领域的感觉。