Collaborative Research: Photonic and Electronic Devices Based on Self-Assembling DNA Templates

合作研究：基于自组装DNA模板的光子和电子器件

• 批准号: 1232239
• 负责人: Gleb Finkelstein
• 金额: $ 22.5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1232239&HistoricalAwards=false
• 关键词: Collaborative; Research; Photonic; Electronic; Devices

The objective of this program is to develop reliable protocols for fabricating functional photonic and electronic nanostructures using bioinspired, molecular assembly methods. In one of the proposed tasks, seed nanoparticles will be selectively attached through molecular recognition to the ?DNA origami? template and fused to form the electrodes; a separate nanoparticle island will be separately attached forming a single-electron transistor. In the other major task, plasmonic bow-tie antennae will be assembled from nanoparticles, and the optically active nanoscale object will be attached in the hot spot. The intellectual merit of the proposed project stems from the convergence of recent advances in DNA-based self-assembly methods with promising preliminary results on specific surface binding of solution-assembled complexes. These nanostructures may develop into a new class of naturally biocompatible sensors that will have transformative applications in the biomedical field. The broader impacts are the development of alternative, cheaper (most steps are in aqueous solution) and more versatile fabrication methods for making composite bio-nano-devices. The proposal has a strongly emphasized outreach component: the PIs plan to recruit MSc students from the North Carolina Central University ? a historically black university (HBCU). The program will train the students in the unique combination of biochemical and physical methods of modern nanotechnology that are relevant for both industrial and academic careers. Disadvantaged high school students (Project SEED) will participate during the summer months to get a feel for the emerging field of nanoscience.

该程序的目的是开发可靠的方案，用于使用生物启发的分子装配方法来制造功能性光子和电子纳米结构。在提议的任务之一中，种子纳米颗粒将通过分子识别选择性地连接到？DNA折纸？模板并融合形成电极；一个单独的纳米颗粒岛将分别连接成单电子晶体管。在另一个主要任务中，等离子弓形触角将从纳米颗粒组装在一起，并且光学活性的纳米级对象将连接在热点。所提出的项目的智力优点源于基于DNA的自组装方法的最新进展的收敛性，并在溶液组装的复合物的特定表面结合上具有有希望的初步结果。这些纳米结构可能会发展为一类新的自然生物相容性传感器，这些传感器将在生物医学领域具有变革性应用。更广泛的影响是开发替代，更便宜的（大多数步骤是在水溶液中），以及用于制造复合生物纳米设备的更通用的制造方法。该提议强调了外展部分：PIS计划招募北卡罗来纳州中央大学的MSC学生？历史悠久的黑人大学（HBCU）。该计划将以与工业和学术职业相关的现代纳米技术的生化和物理方法的独特组合来培训学生。处境不利的高中学生（Project Seed）将在夏季参加，以了解纳米科学的新兴领域。