M3SI - Molecules and Metals for Mass Spectrometric Imaging

M3SI - 用于质谱成像的分子和金属

• 批准号: 207946990
• 负责人: Professor Dr. Michael Linscheid
• 金额: --
• 依托单位: Abteilung 1: Analytische Chemie, Referenzmaterialien
• 依托单位国家: 德国
• 项目类别: Major Instrumentation Initiatives
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/207946990?language=en
• 关键词: M3SI; Molecules; Metals; Mass; Spectrometric

The requested instrumentation will be pivotal for imaging experiments employing the joint expertise of members of the group in optical spectroscopy and mass spectrometry. We aim at the development of a combination of imaging techniques for metals, small active substances, oligomers and biopolymers in biological specimens. Analysis of lateral distributions using LA-ICP-MS and Imaging MALDI MS will be used to study the impact of drug on tissue from several sources. Cooperation with medical schools in Berlin, Hamburg, and Essen will provide the specimens and the questions asked concerning the fate of drugs, nanoparticles as drug delivery vehicles and model compounds, of metals and the target biopolymers. This will be combined with optical microspectroscopic imaging, in particular fluorescence, Raman, and infrared microscopy to provide a true hyphenation of the methods. Methods for the analysis of the molecules will be applied and developed especially for the analysis of modified biopolymers using MALDI MS with high resolution in lateral and mass spectrometric terms.

所要求的仪器将是关键的成像实验采用的联合专家组成员在光谱和质谱。我们的目标是开发一种用于生物标本中金属、小活性物质、低聚物和生物聚合物的成像技术组合。使用LA-ICP-MS和成像MALDI MS进行的横向分布分析将用于研究药物对几种来源组织的影响。与柏林、汉堡和埃森医学院的合作将提供标本和有关药物、作为药物递送载体和模型化合物的纳米颗粒、金属和目标生物聚合物的命运的问题。这将与光学显微光谱成像，特别是荧光，拉曼和红外显微镜相结合，以提供一个真正的方法联用。分子的分析方法将被应用和开发，特别是用于使用MALDI MS在横向和质谱方面具有高分辨率的改性生物聚合物的分析。