Elektrospray-Quadrupol-Time-of-Flight-Massenspektrometer

质谱法在生物和生命科学中已经变得非常重要。与其他大学一样，科隆大学的科隆分子医学中心（CMMC）已经或正在建立主要用于蛋白质组学和脂质分析的质谱设备和特定方法，以及生物系生物中心的新质谱平台（BIO-MS平台）。2007年Dietmar Schomburg教授的研究小组从科隆迁至布伦瑞克工业大学后，使用代谢组分析/质谱法进行代谢网络和酶功能的实验/生物信息学研究在科隆的生物科学领域基本上不存在。通过使用ESI-Q-TOF质谱建立代谢组分析，BIO-MS平台的技术和方法组合至少可以部分填补这一空白。此外，超高分辨率和可能与HPLC或GC系统的在线耦合允许检测可溶性或气态代谢物。这使得该仪器成为未来10到15年用于代谢组学研究的高端、最先进的设备。

Mass spectrometry has become extremely important in biological and life sciences. Like in other universities, MS equipment and specific methods mainly for proteomics and for lipid analytics have been or are currently being established within the University of Cologne at the Center for Molecular Medicine Cologne (CMMC), within the CECAD, and the new MS platform in the Biocenter of the Department of Biology (BIO-MS platform). After the move of the research group of Prof. Dr. Dietmar Schomburg from Cologne to the Technical University of Braunschweig in 2007, experimental/bioinformatics research on metabolic networks and enzymatic function using metabolome analysis/mass spectrometry became largely inexistent in the biological sciences in Cologne. This gap should now at least in part be filled with the technological and methodological portfolio of the BIO-MS platform through establishment of metabolome analysis using an ESI-Q-TOF MS. Moreover, ultrahigh resolution and the possible online coupling to a HPLC or GC system allows for the detection of soluble or gaseous metabolites. This makes this instrument a high-end, state-of-the-art equipment for metabolomics research for the next ten to fifteen years.