I-Corps: InCh holographic microscope for cell diagnostics
I-Corps:用于细胞诊断的 InCh 全息显微镜
基本信息
- 批准号:1247419
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This ICorps project seeks to evaluate the business opportunity for a new optical cellular imaging modality for use at the clinical point of care. The microscope system will employ a unique sample holder, called the interferometric-chamber (InCh) which enables holographic imaging of cell morphology with a simple, inexpensive yet robust optical system. Significantly, this approach does not require any sample preparation, such as addition of fluorescent labels, and obtains wide field images of cell samples in a single acquisition, i.e., no sample or optical scan is needed. Holographic cell images can be easily processed to calculate numerical morphological parameters of individual cells and thus provide important information for medical diagnosis and health status. The proposed team will critically evaluate the commercial need, target markets and develop a licensing strategy as well as create a commercial prototype of the InCh microscope for demonstration to potential partners and investors. The long-range goal of this research is to create a new biomedical diagnostic product for the purpose of generating holographic cell images, particularly red blood cells, at the point of care using a simple, robust imaging device. Initial testing will be conducted on red blood cells to calculate parameters usually obtained by manual cell counting of blood smear samples. Further applications include identifying abnormalities of the red and white blood cells due to malaria, chagas and sickle cell anemia as well as real time imaging of living cells for laboratory applications such as cancer biology and stem cell research. This research has significant transformative potential in that it can dramatically increase the availability of diagnostic information at the point of care. If successful, this technology can impact healthcare domestically as well as in the developing world. Further, this technology can be used as a tool to enable future discoveries by providing a means to obtain and rapidly analyze information from blood samples for biomedical studies.
ICorps项目旨在评估用于临床护理点的新型光学细胞成像模式的商业机会。显微镜系统将采用一种独特的样品支架,称为干涉室(英寸),它可以用简单,廉价但坚固的光学系统对细胞形态进行全息成像。值得注意的是,这种方法不需要任何样品制备,例如添加荧光标记,并且在单次采集中获得细胞样品的宽视场图像,即不需要样品或光学扫描。全息细胞图像可以很容易地处理计算单个细胞的数值形态参数,从而为医学诊断和健康状况提供重要信息。该团队将严格评估商业需求,目标市场,制定许可策略,并创建InCh显微镜的商业原型,以向潜在的合作伙伴和投资者展示。这项研究的长期目标是创造一种新的生物医学诊断产品,用于在护理点使用简单,强大的成像设备生成全息细胞图像,特别是红细胞。将对红细胞进行初步检测,以计算通常通过手工血液涂片样本细胞计数获得的参数。进一步的应用包括识别由于疟疾、南美锥虫病和镰状细胞性贫血引起的红细胞和白细胞异常,以及用于癌症生物学和干细胞研究等实验室应用的活细胞实时成像。这项研究具有重大的变革潜力,因为它可以极大地增加护理点诊断信息的可用性。如果成功,这项技术可以影响国内以及发展中国家的医疗保健。此外,这项技术可以作为一种工具,通过为生物医学研究提供从血液样本中获取和快速分析信息的手段,从而实现未来的发现。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adam Wax其他文献
777 Label-Free Nuclear Morphology Measurements of Dysplasia in the Egda Rat Model Using Angle-Resolved Low Coherence Interferometry
777 使用角度分辨低相干干涉仪对 Egda 大鼠模型中的发育不良进行无标记核形态学测量
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Adam Wax;Yizheng Zhu;Neil G. Terry;Xiaoxin Chen;S. Gebhart;W. Brown - 通讯作者:
W. Brown
In vivo Rat Skin Flap Viability Assessment using Dual Axis Spectroscopic Optical Coherence Tomography
使用双轴光谱光学相干断层扫描进行体内大鼠皮瓣活力评估
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Yang Zhao;Jason R. Maher;Mohamed M Ibrahim;Jennifer S. Chien;H. Levinson;Adam Wax - 通讯作者:
Adam Wax
Response to Comment on “Is the nuclear refractive index lower than cytoplasm? Validation of phase measurements and implications for light scattering technologies”
对“核折射率低于细胞质吗?相位测量的验证及其对光散射技术的影响”的评论的回应
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:2.8
- 作者:
Zachary A. Steelman;W. Eldridge;Adam Wax - 通讯作者:
Adam Wax
Deep learning classification of ex vivo human colon tissues using spectroscopic OCT
使用光谱 OCT 对离体人类结肠组织进行深度学习分类
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Wesley Y. Kendall;Qinyi Tian;Shi Zhao;Seyedbabak Mirminachi;Abel Joseph;Darin Dufault;Chanjuan Shi;Jatin Roper;Adam Wax - 通讯作者:
Adam Wax
An electron spin resonance investigation of the structure and formation of sulfinyl radicals: Reaction of peroxyl radicals with thiols
亚磺酰自由基的结构和形成的电子自旋共振研究:过氧自由基与硫醇的反应
- DOI:
10.1021/j100338a034 - 发表时间:
1989 - 期刊:
- 影响因子:0
- 作者:
K. Chu;Yang Zhao;Evan T. Jelly;Zachary A. Steelman;Michael Crose;Brian Cox;Yaa Ofori;Lama Moussa;H. Cirri;Ariel E. Watts;Nicholas H. Shaheen;Adam Wax - 通讯作者:
Adam Wax
Adam Wax的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Adam Wax', 18)}}的其他基金
Angle resolved light scattering through a multimode fiber for measuring cell nuclei morphology
通过多模光纤进行角度分辨光散射,用于测量细胞核形态
- 批准号:
2009841 - 财政年份:2020
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
PFI-TT: Increasing commercial potential of deep skin imaging using OCT.
PFI-TT:增加使用 OCT 进行深层皮肤成像的商业潜力。
- 批准号:
1827560 - 财政年份:2018
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Visualization of mechanical stress in live cells
活细胞机械应力的可视化
- 批准号:
1604562 - 财政年份:2016
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
EAGER: Cell phone enabled spectroscopy
EAGER:手机支持的光谱学
- 批准号:
1445992 - 财政年份:2014
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Increased Depth Penetration in Coherence Imaging Using Multiply Scattered Light
使用多重散射光增强相干成像的深度穿透力
- 批准号:
1133222 - 财政年份:2011
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
MRI: Development of a hybrid quantitative phase microscope for live cell imaging
MRI:开发用于活细胞成像的混合定量相显微镜
- 批准号:
1039562 - 财政年份:2010
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Molecular imaging of live cells using hyperspectral darkfield microscopy
使用高光谱暗场显微镜对活细胞进行分子成像
- 批准号:
0651622 - 财政年份:2007
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
CAREER: Low Coherence Light Scattering for Biophotonics
职业:生物光子学的低相干光散射
- 批准号:
0348204 - 财政年份:2004
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
相似海外基金
Science of Inch-Diameter Diamond Heteroepitaxial Growth on Lattice-Mismatched Substrate
晶格失配基底上英寸直径金刚石异质外延生长科学
- 批准号:
22H01974 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
CANada in the INCremental dialysis to improve Health outcomes in people starting Hemodialysis (CAN INCH-HD) study: a randomized controlled trial
加拿大开展增量透析以改善开始血液透析患者的健康结果 (CAN INCH-HD) 研究:一项随机对照试验
- 批准号:
452633 - 财政年份:2021
- 资助金额:
$ 5万 - 项目类别:
Operating Grants
Impact of long viewing distance to 5k-inch screen on physical fatigue and task performance
5k英寸屏幕长观看距离对身体疲劳和任务表现的影响
- 批准号:
20K12522 - 财政年份:2020
- 资助金额:
$ 5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Research & creation of High-DPI (Dots per Inch) and Touch-Friendly UI components for control system
研究
- 批准号:
517405-2017 - 财政年份:2017
- 资助金额:
$ 5万 - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
2 Inch VIM Qualification Project
2英寸VIM资质项目
- 批准号:
498396-2016 - 财政年份:2016
- 资助金额:
$ 5万 - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
Basic study for development of inch-scale diamond wafers
英寸级金刚石晶片开发基础研究
- 批准号:
26600096 - 财政年份:2014
- 资助金额:
$ 5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Langton Robotic Telescope providing wide access to a 16 inch Schmidt Cassegrain telescope via the web for schools and the public.
兰顿机器人望远镜为学校和公众提供了通过网络广泛访问 16 英寸施密特卡塞格林望远镜的机会。
- 批准号:
ST/L001470/1 - 财政年份:2013
- 资助金额:
$ 5万 - 项目类别:
Research Grant
GOALI: Three-dimensional Magnetic Recording At Areal Densities Above 1 Terabit-per-square-inch
目标:面密度超过每平方英寸 1 太比特的三维磁记录
- 批准号:
1102074 - 财政年份:2011
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
Development of novel magnetic printing technology for servo signal writing on hard disks over 1 Tbit/square inch
开发新型磁打印技术,用于在超过 1 Tbit/平方英寸的硬盘上写入伺服信号
- 批准号:
21360159 - 财政年份:2009
- 资助金额:
$ 5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
STTR Phase I: Multilevel Magnetic Recording for Areal Densities Above 10 Terabit-per-square-inch
STTR 第一阶段:面密度超过 10 太比特每平方英寸的多级磁记录
- 批准号:
0810357 - 财政年份:2008
- 资助金额:
$ 5万 - 项目类别:
Standard Grant