Increased Depth Penetration in Coherence Imaging Using Multiply Scattered Light

使用多重散射光增强相干成像的深度穿透力

• 批准号: 1133222
• 负责人: Adam Wax
• 金额: $ 30万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1133222&HistoricalAwards=false
• 关键词: Increased; Depth; Penetration; Coherence; Imaging

1133222WaxThe PI proposes to develop ms/LCI (multiple scattering/low coherence interferometry) to image through thick tissues with multiply scattered light. The specific tasks proposed are: 1. Instrument development:The system will be modified to enable optical scanning and multispectral interferometric imaging. Optical scanning will improve the speed of acquiring 2D images while inclusion of multiple illumination wavelengths will allow recovery of important biochemical information such as hemoglobin concentration and oxygenation. 2. Theoretical modeling:To better understand the mechanisms of imaging contrast in this approach the PI will take a dual pronged effort to model the light propagation. An analytical form is presented which is based on a random walk formalism that will be used to evaluate this imaging modality. To validate this model, they will also use Monte Carlo modeling as well as comparing to experimental results. 3. Demonstrate imaging of hemoglobin distribution in thick tissues.To demonstrate the utility of the method, they will image hemoglobin distribution through thick (~1 cm) tissues. Samples will include tissue phantoms, designed to validate the method, and ex vivo animal tissues, such as muscle and fat as would be encountered in breast imaging and retinal samples as would be used in OCT ophthalmic imaging, where penetration to the choroid has remained a challenge. The proposed research will advance a novel imaging modality with unique potential to extend imaging depth. In addition, new multispectral interferometry instrumentation will advance optical engineering while the proposed random walk model will advance understanding of light propagation in tissues.

1133222 Wax PI建议开发ms/LCI（多重散射/低相干干涉测量法），以便使用多重散射光通过厚组织成像。提出的具体任务是：1.仪器开发：将对该系统进行改造，以便能够进行光学扫描和多光谱干涉成像。光学扫描将提高获取2D图像的速度，同时包含多个照明波长将允许恢复重要的生化信息，例如血红蛋白浓度和氧合。2.理论建模：为了更好地理解这种方法中成像对比度的机制，PI将采取双管齐下的努力来对光传播进行建模。提出了一种分析形式，这是基于随机游走形式主义，将用于评估这种成像方式。为了验证这个模型，他们还将使用蒙特卡罗建模以及与实验结果进行比较。3.演示厚组织中血红蛋白分布的成像。为了演示该方法的实用性，他们将通过厚（约1 cm）组织成像血红蛋白分布。样本将包括组织体模（设计用于验证该方法）和离体动物组织（如乳房成像中遇到的肌肉和脂肪）以及OCT眼科成像中使用的视网膜样本（其中穿透脉络膜仍然是一个挑战）。拟议的研究将推进一种新的成像方式，具有独特的潜力，以扩大成像深度。此外，新的多光谱干涉测量仪器将推进光学工程，而提出的随机游走模型将促进对组织中光传播的理解。