2013 CSHL Computational Cell Biology Conference

该奖项支持2013年3月19日至22日在冷泉港实验室(CSHL)举行的两年一度的计算细胞生物学会议：模型与数据之间的相互作用。这次会议聚集了一群不同的科学家，他们利用计算机模拟和数学模型研究细胞过程的分子、结构和功能方面。计算细胞生物学是一个跨学科的领域，主要研究如何模拟驱动活细胞生理行为的分子机制。为了建立这些过程的有用的定量模型，计算科学家必须与实验细胞生物学家密切合作；在这种合作关系中，实验学家收集关于细胞过程以及它们如何随时间变化的数据，而数学家则利用这些信息来建立和改进准确反映生物学的计算机模型。CSHL会议通过提供一个论坛来促进细胞生物学知识的发展，在这个论坛上，研究动态细胞过程的所有方面的科学家可以相互交流，交流想法、信息和方法，从数据生成和分析到定量模型的开发和验证。会议包括信号处理、噪声、细胞力学、发育、合成生物学、成像、进化和生物系统的组织原则等方面的会议。2013年的会议建立在之前CSHL会议的成功基础上，以召集科学家的国际会议，讨论该领域的新发展，并催化创新研究合作。计算细胞生物学学科寻求开发生命系统的数学模型，例如健康细胞和癌症细胞分裂期间的分子相互作用。这种模型的目标有两个：1)预测细胞内动力系统的结果，从而使科学家能够解释细胞过程在疾病中是如何出错的。为了建立成功的模型，数学家和计算机科学家必须与实验细胞生物学家密切合作。在这种合作关系中，实验学家收集关于细胞过程以及它们如何随时间变化的定量信息，而数学家则利用这些信息来建立和改进准确反映生物学的计算机模型。冷泉港计算细胞生物学实验室会议：模型和数据之间的相互作用通过将拥有实验和计算技术专业知识的科学家聚集在一起，从而促进科学互动，最终加快发现的步伐，从而促进该领域的知识。

This award supports the biennial conference on Computational Cell Biology: The Interplay between Models and Data, which takes place March 19-22, 2013, at Cold Spring Harbor Laboratory (CSHL). This meeting brings together a diverse group of scientists who study the molecular, structural, and functional aspects of cellular processes by using computer simulations and mathematical models. The interdisciplinary field computational cell biology is focused on the simulation of molecular machinery that drives the physiological behavior of living cells. To build useful quantitative models of these processes, computational scientists must work closely with experimental cell biologists; in this partnership, experimentalists collect data about cellular processes and how they change over time, while mathematicians use the information to build and improve upon computer models that accurately reflect the biology. The CSHL conference advances knowledge in cell biology by providing a forum where scientists who study all aspects of dynamic cellular processes, from data generation and analysis to the development and validation of quantitative models, can interact with each other and exchange ideas, information, and approaches. The conference includes sessions on signal processing, noise, cell mechanics, development, synthetic biology, imaging, evolution, and organizing principles of biological systems. The 2013 meeting builds on the successes of prior CSHL meetings to assemble an international gathering of scientists, discuss new developments in the field, and catalyze innovative research collaborations.The discipline of computational cell biology seeks to develop mathematical models of living systems, such as molecular interactions during cell division in both healthy cells and cancer. The goals for such models are twofold: 1) predict outcomes from dynamical systems in the cell, thereby allowing scientists to 2) explain how cellular processes go awry in disease. To build successful models, mathematicians and computer scientists must work closely with experimental cell biologists. In this partnership, experimentalists collect quantitative information about cellular processes and how they change over time, while mathematicians use the information to build and improve upon computer models that accurately reflect the biology. The Cold Spring Harbor Laboratory conference on Computational Cell Biology: The Interplay between Models and Data advances knowledge in the field by bringing together scientists with expertise in both experimental and computational techniques, thus catalyzing scientific interactions that will ultimately accelerate the pace of discovery.