Conference: CSHL Advanced Courses for Model Genetic Systems (2023-2025)

冷泉港实验室(CSHL)模型遗传系统高级课程在培训新手在细菌、酵母和植物中使用遗传和基因组方法方面发挥了关键作用。这些为期三周的高强度课程涵盖了各自系统中的遗传学基础，然后为随着课程进展而涵盖的更复杂的基因组方法奠定了概念上的支柱。课程的动手实验部分通常包括多天的模块，并辅之以每天的理论讲座，讲师因其在该系统方面的成熟专业知识而被选中，并由利用各自系统的知名研究人员举办一系列世界级研讨会。因此，每个学生都可以接触到他们被教授的方法的基本原理，以及该领域专家对方法的最新应用。这些课程因服务于不同的生物学家社区以及培训来自物理科学的研究人员而享有盛誉。这些学生从早期的研究生到终身教授，他们的背景包括遗传学、分子和细胞生物学、生物信息学、工程学和物理学。自从他们在20世纪70年代和80年代初成立以来，CSHL的高级细菌遗传学、酵母遗传学和植物科学的前沿与技术暑期课程(统称为模型遗传学系统课程)在向对遗传学和基因组学中使用模型系统感兴趣的广泛科学界传播新方法和技术方面发挥了关键作用。拟议的课程(2023-2025年)将延续这一传统，提供利用经典遗传和分子生物学方法、遗传相互作用分析和基因组学在这些模型系统中工作的基础方面的高级培训。每个课程都包括动手实验模块、精力充沛的系列讲座、技术演示和演示以及非正式讨论。讲师和特邀演讲者是各自领域公认的领导者，他们提出了关于广泛主题的最新研究。这种非正式、高度互动的课程形式使学生和教学学徒可以相互学习，也可以向讲师和特邀演讲者学习。总而言之，这些课程提供了为期三周的跨学科和尖端方法的密集沉浸，帮助下一代微生物学家和植物科学家准备将最新的遗传/基因组工具和方法应用于他们自己的研究，通常是在非模型和“现实世界”应用中。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The Cold Spring Harbor Laboratory (CSHL) Advanced Courses in Model Genetic Systems serve a critical role in the training of investigators new to the use of genetic and genomic approaches in bacteria, yeast and plants. These highly intensive three-week courses cover the fundamentals of genetics in the respective system, which then establishes the conceptual backbone for the more sophisticated genomic methods that are covered as the courses progress. The hands-on experimental portion of the courses, often including multi-day modules, are complemented by daily theoretical lectures by instructors chosen for their proven expertise in the system and a world class seminar series from renowned investigators that utilize the respective system. As a result, every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The courses have a well-established reputation for serving a diverse community of biologists as well as training researchers from the physical sciences. The students range from early-stage graduate students to tenured professors, with backgrounds in areas including genetics, molecular and cellular biology, bioinformatics, engineering, and physics.Since their foundation in the 1970s and early 1980s, the CSHL summer courses on Advanced Bacterial Genetics, Yeast Genetics & Genomics and Frontiers & techniques in Plant Science (collectively, the Model Genetics Systems courses) have each played a critical role in disseminating new approaches and techniques to the broad scientific community interested in the use of model systems in genetics and genomics. The proposed courses (2023-2025) will continue this tradition by providing advanced training in the fundamentals of working in these model systems making use of classical genetic and molecular biological approaches, analysis of genetic interactions, and genomics. The courses each consist of hands-on laboratory modules, a vigorous lecture series, technical presentations and demonstrations, and informal discussions. The instructors and invited speakers, acknowledged leaders in their fields, present up-to-the-moment research on a wide range of topics. The informal, highly interactive course format allows students and teaching apprentices to learn from each other as well as from the instructors and invited speakers. In sum, the courses provide for intensive three-week immersion into cross-disciplinary and cutting-edge approaches, helping prepare the next generation of microbiologists and plant scientists to apply the latest genetic/genomic tools and approaches to their own research, often in non-model and “real world” applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.