CSHL Course on Yeast Genetics & Genomics

知识价值：冷泉港实验室为期三周的酵母遗传学和基因组学暑期课程，为学生进行分子遗传学的现代科学研究做准备。这门以实验室为基础的高强度课程旨在使每个学生熟练掌握酵母遗传学的基础知识，然后为更复杂的分子技术(如基因组编辑和下一代测序)奠定概念基础。课程的实验部分由讲师每天的理论讲座和世界级的研讨会系列组成，讲师因其在该系统中的成熟专业知识而被选中，而著名的研究人员利用酵母系统进行了一系列的研讨会。虽然课程的总体组织结构每年都保持不变，但随着酵母生物学和基因组学方法的进步，内容也会发生变化；随着教师的更替，课程将增加新的专业知识，新的教师会将最新的技术和方法纳入课程。课程参与者是从从早期职业科学家到高级研究人员的高素质申请者中挑选出来的，他们来自不同的研究背景，包括生物、化学、工程、物理、数学和计算机科学。广泛的影响：该课程培训研究人员在酵母模型中进行生物研究的最新实验和计算资源和工具，并培训教师使用酵母来演示真核生物的基本概念。许多学生可能在不久的将来承担教育和监督责任；其他人已经是教授或博士后研究员，他们将立即传授他们在课程中学到的知识。许多参加这门课程的学生继续领导自己的实验室，这门课程为这些新的实验室负责人提供了知识基础和重要的科学联系网络。近年来，男女学生人数均等，人数不足的少数族裔学生参加了该课程。为了进一步推动这一趋势，该课程被广泛宣传，并与促进招募和留住未被充分代表的群体进入生命科学研究社区的机构项目建立了具体联系。实验方案和相关材料由冷泉港实验室出版社出版发行。

Intellectual Merit: Cold Spring Harbor Laboratory's three-week summer course on Yeast Genetics and Genomics prepares students for modern scientific research in molecular genetics. The highly intensive laboratory-based course work is designed to make each student proficient in the fundamentals of yeast genetics, which then establishes the conceptual backbone for more sophisticated molecular technologies such as genome editing and next generation sequencing. The experimental portion of the course is complemented by daily theoretical lectures by instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. Although the general organization of the course is intended to remain the same from year to year, changes in content are introduced as yeast biology and genomic approaches advance; as instructors are replaced new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Course participants are chosen from a pool of highly qualified applicants ranging from early career scientists to senior investigators and coming from diverse research backgrounds, including biology, chemistry, engineering, physics, mathematics and computer science.Broader Impacts: The course trains researchers in the most up-to-date experimental and computational resources and tools available for biological research in the yeast model, and trains teachers in the use of yeast to demonstrate the fundamental concepts of eukaryotic biology. Many of the students are likely to have educational and supervisory responsibilities in the near future; others are already professors or post-doctoral fellows who will immediately pass on what they have learned in the course. Many of the students who take the course go on to lead their own laboratories, with the course providing a foundation of knowledge and an important network of scientific contacts for these new lab heads. In recent years, female and male students were equally represented and under-represented minority students took part in the course. To further this trend, the course is advertised widely and specific contacts are made to institutional programs that facilitate recruiting and retention of underrepresented groups into the life sciences research community. The experimental protocols and associated materials are disseminated via publication by Cold Spring Harbor Laboratory Press.