CONFERENCE: Cold Spring Harbor Laboratory Synthetic Biology Course-July 27-August 10, 2015

合成生物学是一个快速发展的多学科研究领域，它依赖于生物学、工程学、数学、化学和物理学的专业知识的整合。该领域使用理论和工程原理来推进基本的生物学理解和开发生物灵感产品。当今合成生物学面临的挑战是，跨学科的专业知识往往很少，而对各种潜在领域的基本理解对于促进成功的合作至关重要。这门课程（2015年7月27日至8月10日）通过冷泉港暑期课程教育计划提供，代表了解决这一需求的重大努力。该系列讲座包括在实验室中接触实验和理论合成生物学的前沿进展。该课程旨在激励参与者与他们所在机构的同事分享他们的知识，这可能会对系统和合成生物学课程和课程开发产生更广泛的启发。本课程将有助于推动新兴的跨学科科学，除了提供对生物学复杂性的见解之外，还将激发创新，为许多当前和即将到来的社会需求提供关键解决方案。本课程满足了培养跨学科研究人员的重要需求，使他们更加了解跨学科合作所带来的机会，包括学生和专家之间的有效沟通。教材包括一些前沿培训领域，如CRISPR技术的理论和应用，以改变复杂生物系统的基因组；熟练掌握无细胞转录-翻译（TX-TL）方法；金门组装法快速分子克隆；并通过常微分方程获得对计算生物学的基本理解。此外，课程将提供开发特定生物传感器用于代谢工程的课程。

Synthetic biology is a rapidly expanding multi-disciplinary research area that relies on the integration of expertise in biology, engineering, mathematics, chemistry, and physics. This field uses theoretical and engineering principles to advance fundamental biological understanding and develop bio-inspired products. The challenge of synthetic biology today is that interdisciplinary expertise is often minimal, whereas a basic comprehension of the various underlying fields is crucial to foster successful collaborations. This course (July 27 - August 10, 2015) offered through the Cold Spring Harbor summer course educational program represents a significant effort to address this need. The series of lectures include laboratory exposure to cutting edge advances in experimental and theoretical synthetic biology. The course is structured to motivate the participants to share their knowledge with colleagues at their home institutions, which may inspire more broadly a systems and synthetic biology course and curriculum development. This course will help advance an emerging interdisciplinary science that, in addition to providing insights into the complexity of biology, will also inspire innovations that can provide critical solutions for many current and impending societal needs. The course fulfills an important need for development of an interdisciplinary research workforce that is more aware of the opportunities that can be realized from interdisciplinary collaborations including effective communication between students and experts. The teaching material includes cutting edge training in such areas as the theory and use of CRISPR technology to alter the genome of complex biological systems; proficiency in cell-free transcription-translation (TX-TL) methods; rapid molecular cloning using the Golden Gate assembly method; and gaining fundamental understanding of computational biology using ordinary differential equations. In addition, the course will provide sessions to develop specific biosensors for metabolic engineering.