CONFERENCE: Cold Spring Harbor Laboratory Synthetic Biology Course-July 27-August 10, 2015

合成生物学是一个迅速发展的多学科研究领域，它依赖于生物学、工程学、数学、化学和物理学的专业知识的整合。该领域使用理论和工程原理来促进对生物学的基本理解，并开发生物启发产品。合成生物学今天面临的挑战是，跨学科的专业知识往往微乎其微，而对各种基本领域的基本理解对于促进成功的合作至关重要。该课程(2015年7月27日至8月10日)通过冷泉港暑期课程教育项目提供，是满足这一需求的重大努力。该系列讲座包括实验室接触实验和理论合成生物学的前沿进展。课程的结构是为了激励参与者与本国机构的同事分享他们的知识，这可能会激励更广泛的系统和合成生物学课程和课程的开发。这门课程将有助于推进一门新兴的跨学科科学，除了提供对生物学复杂性的见解外，还将激发创新，为许多当前和迫在眉睫的社会需求提供关键的解决方案。该课程满足了培养一支跨学科研究队伍的重要需要，该队伍更清楚地认识到跨学科合作可以实现的机会，包括学生和专家之间的有效沟通。教材包括以下领域的前沿培训：改变复杂生物系统基因组的CRISPR技术的理论和使用；熟练使用无细胞转录-翻译(TX-TL)方法；使用金门组装方法进行快速分子克隆；以及使用常微分方程式获得计算生物学的基本知识。此外，本课程还将提供为代谢工程开发特定生物传感器的课程。

Synthetic biology is a rapidly expanding multi-disciplinary research area that relies on the integration of expertise in biology, engineering, mathematics, chemistry, and physics. This field uses theoretical and engineering principles to advance fundamental biological understanding and develop bio-inspired products. The challenge of synthetic biology today is that interdisciplinary expertise is often minimal, whereas a basic comprehension of the various underlying fields is crucial to foster successful collaborations. This course (July 27 - August 10, 2015) offered through the Cold Spring Harbor summer course educational program represents a significant effort to address this need. The series of lectures include laboratory exposure to cutting edge advances in experimental and theoretical synthetic biology. The course is structured to motivate the participants to share their knowledge with colleagues at their home institutions, which may inspire more broadly a systems and synthetic biology course and curriculum development. This course will help advance an emerging interdisciplinary science that, in addition to providing insights into the complexity of biology, will also inspire innovations that can provide critical solutions for many current and impending societal needs. The course fulfills an important need for development of an interdisciplinary research workforce that is more aware of the opportunities that can be realized from interdisciplinary collaborations including effective communication between students and experts. The teaching material includes cutting edge training in such areas as the theory and use of CRISPR technology to alter the genome of complex biological systems; proficiency in cell-free transcription-translation (TX-TL) methods; rapid molecular cloning using the Golden Gate assembly method; and gaining fundamental understanding of computational biology using ordinary differential equations. In addition, the course will provide sessions to develop specific biosensors for metabolic engineering.