Conference: 2013 CSHL Eukaryotic mRNA Processing Conference tobe held in Cold Springs Harbor, NY on August 20-24, 2013

概述：冷泉港实验室CONFERENCEEUKARYOTIC mRNA PROCESSINGAUGUST 20-24,2013拟议中的‘真核mRNA加工’会议将召集科学家们研究mRNA加工、运输、RNA干扰、信息学和翻转的各个方面。最近在这些领域取得了重大进展，拟议的会议将是一个及时的活动，可以讨论最新的未公布结果和交流意见，从而促进这一快速发展领域的新发展。拟议的2013年会议将于8月举行，是每隔一年在冷泉港实验室举行的会议的第九次会议。最近的一次会议于2011年8月举行，吸引了来自世界各地的335名科学家，他们正在利用遗传学、生化、分子和细胞生物学方法，积极研究真核细胞中信使RNA成熟的各个方面。智力优势：与前几次会议一样，会议的主要重点将是信使核糖核酸成熟中的核事件，包括信使核糖核酸剪接和聚腺苷酸化，以及信使核糖核酸成熟与癌症病因的相关性，信使核糖核酸成熟步骤之间的联系，RNA干扰和微RNA功能的新兴领域，以及信息学和全基因组方法在RNA加工分析中的应用。会议形式将包括八次全体会议和两次海报会议。每一次全体会议将细分为两个部分(以咖啡休息为间隔)，集中讨论相关但不同的主题。在2011年会议上成功试行的这一分组，使我们能够专门寻找更广泛的领域代表性，并招募更多样化的教职员工担任届会主席。所有发言者将一如既往地根据提交的摘要选出，这将鼓励初级科学家积极参与。我们将特别鼓励领导这些项目的学生和博士后研究员展示未发表的作品，这一直是冷泉港会议的标志和独特优势。更广泛的影响：拟议活动的更广泛影响是多方面的。首先，它们包括对真核细胞mRNA加工以外的其他领域的科学影响，因为该领域的发现将继续促进基础发现和洞察的快速步伐，以便我们更充分地了解高等生物中的基因表达。其次，它们还包括教育、培训、资源共享以及互动和合作机会等要素。尤其是，会议将提供：(1)为初级科学家提供培训机会，以促进陈述技能的发展以及整体科学素质和分析的严谨性；(2)为所有职业级别的科学家提供一个促进有意义的科学互动的亲密环境；(3)在多层次的研究和教育机构中传播知识；(4)共享材料和信息资源；以及(V)开展合作的机会，这可以使来自较小实验室和/或主要来自本科(教学)机构的科学家受益，这些机构可能比主要研究机构的科学家拥有更少的资源和更有限的机会获得尖端技术。

Overview:COLD SPRING HARBOR LABORATORY CONFERENCEEUKARYOTIC mRNA PROCESSINGAUGUST 20 - 24, 2013The proposed conference on 'Eukaryotic mRNA Processing' will convene scientists studying various aspects of mRNA processing, transport, RNA interference, informatics and turn-over. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging ideas, thereby fostering new developments in this rapidly moving field. The proposed 2013 conference will be held in August and is the ninth meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The most recent meeting was held in August 2011 and attracted 335 scientists internationally, who are actively investigating various aspects of messenger RNA maturation in eukaryotic cells, using genetic, biochemical, molecular, and cell biological approaches. Intellectual Merit:As in the previous meetings, a major focus will be on nuclear events in mRNA maturation, including mRNA splicing and polyadenylation, as well as the relevance of mRNA maturation to the etiology of cancer, the connections between mRNA maturation steps, the emerging fields of RNA interference and microRNA function and the application of informatics and genome-wide approaches to the analysis of RNA processing. The meeting format will consist of eight plenary sessions and two poster sessions. Each plenary session will be subdivided into two parts (separated by a coffee break) that focus on related but separate topics. This subdivision, successfully piloted at the 2011 meeting, allows us to specifically seek out a broader representation of fields and to recruit a more diverse set of faculty as session chairs. As always, all speakers will be selected on the basis of the submitted abstracts, which will encourage active participation by junior scientists. We will particularly encourage presentation of unpublished work by the students and postdoctoral fellows who are leading these projects, as has traditionally been a hallmark and a unique strength of the Cold Spring Harbor meetings.Broader Impacts:The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond eukaryotic mRNA processing of, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights in our efforts to more fully understand gene expression in higher organisms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions.