Conference: 2013 CSHL Eukaryotic mRNA Processing Conference tobe held in Cold Springs Harbor, NY on August 20-24, 2013

概述：冷泉港实验室会议真核生物mRNA 2013年8月20 - 24日新加坡拟议的会议“真核生物mRNA加工”将召集科学家研究mRNA加工，运输，RNA干扰，信息学和周转的各个方面。最近在这些领域取得了重大进展，拟议的会议将是一个及时的事件，讨论最新的未发表的结果和交流思想，从而促进这一迅速发展的领域的新发展。拟议中的2013年会议将于8月举行，是每隔一年在冷泉港实验室举行的一次会议的第九次会议。最近一次会议于2011年8月举行，吸引了335名国际科学家，他们正在积极研究真核细胞中信使RNA成熟的各个方面，使用遗传，生物化学，分子和细胞生物学方法。智力优势：在以前的会议，一个主要的重点将是在mRNA成熟的核事件，包括mRNA剪接和聚腺苷酸化，以及mRNA成熟的癌症病因学的相关性，mRNA成熟步骤之间的连接，RNA干扰和microRNA功能的新兴领域和信息学和全基因组方法的应用分析RNA加工。会议形式将包括八次全体会议和两次海报会议。每次全体会议将分为两个部分（中间有一个喝咖啡的休息时间），重点讨论相关但独立的主题。这种细分，在2011年的会议上成功试点，使我们能够特别寻求领域的更广泛的代表性，并招募一组更多样化的教师作为会议主席。一如既往，所有发言者都将根据提交的摘要挑选，这将鼓励年轻科学家积极参与。我们将特别鼓励领导这些项目的学生和博士后研究员发表未发表的工作，这一直是冷泉港会议的传统标志和独特优势。更广泛的影响：拟议活动的更广泛的影响是多方面的。首先，它们包括对真核mRNA加工以外的其他领域的科学影响，因为这一领域的发现将继续促进我们更全面地了解高等生物中基因表达的基本发现和见解的快速发展。其次，它们还包括教育、培训、资源共享以及互动和合作机会等要素。特别是，会议将提供：㈠为年轻科学家提供培训机会，以促进发展演讲技巧以及全面的科学素质和分析严谨性; ㈡提供一个亲密的环境，以促进所有职业层次的科学家之间有意义的科学互动; ㈢在研究和教育机构的多个层次之间传播知识;（iv）分享物质和信息资源;（v）提供开展合作的机会，这可使来自小型实验室和/或主要来自本科（教学）机构的科学家受益，他们的资源可能比来自大型研究机构的科学家少，接触尖端技术的机会也更有限。

Overview:COLD SPRING HARBOR LABORATORY CONFERENCEEUKARYOTIC mRNA PROCESSINGAUGUST 20 - 24, 2013The proposed conference on 'Eukaryotic mRNA Processing' will convene scientists studying various aspects of mRNA processing, transport, RNA interference, informatics and turn-over. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging ideas, thereby fostering new developments in this rapidly moving field. The proposed 2013 conference will be held in August and is the ninth meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The most recent meeting was held in August 2011 and attracted 335 scientists internationally, who are actively investigating various aspects of messenger RNA maturation in eukaryotic cells, using genetic, biochemical, molecular, and cell biological approaches. Intellectual Merit:As in the previous meetings, a major focus will be on nuclear events in mRNA maturation, including mRNA splicing and polyadenylation, as well as the relevance of mRNA maturation to the etiology of cancer, the connections between mRNA maturation steps, the emerging fields of RNA interference and microRNA function and the application of informatics and genome-wide approaches to the analysis of RNA processing. The meeting format will consist of eight plenary sessions and two poster sessions. Each plenary session will be subdivided into two parts (separated by a coffee break) that focus on related but separate topics. This subdivision, successfully piloted at the 2011 meeting, allows us to specifically seek out a broader representation of fields and to recruit a more diverse set of faculty as session chairs. As always, all speakers will be selected on the basis of the submitted abstracts, which will encourage active participation by junior scientists. We will particularly encourage presentation of unpublished work by the students and postdoctoral fellows who are leading these projects, as has traditionally been a hallmark and a unique strength of the Cold Spring Harbor meetings.Broader Impacts:The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond eukaryotic mRNA processing of, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights in our efforts to more fully understand gene expression in higher organisms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions.