AgriSense: Multichannel disposable sensors for animal health disease diagnostics

1264705(沃格尔)。快速和灵敏地检测活体动物中与牛呼吸道疾病(BRD)相关的病毒感染被认为是将该疾病的影响降至最低的关键。目前，最常见的血清学诊断方法是荧光标记的ELISA。基于ELISA法的检测是有限的，因为它通常依赖于在每个ELISA板上检测单个检测样本中的单个病毒抗体亚型，检测相对缓慢(长达1周)和昂贵(每次检测约5美元)。一个低成本的多路平台，能够在同一检测方法中检测与BRD感染相关的几个抗体标志物，将为常规血清学检测提供显著的经济效益。此外，快速的农场？牛边？多重诊断能力将是朝着更有效、更有效地管理、控制和/或根除与BRD相关的病原体的方向迈出的重要一步。目前，动物卫生部门还没有用于疾病诊断的电子场测试，更不用说BRD了。我们的团队将通过构建廉价的电化学传感器来检测与BRD感染相关的生物标记物，以应对这些挑战。

1264705(Vogel). Rapid and sensitive detection of bovine respiratory disease (BRD)-associated viral infections in live animals is recognized as key to minimizing the impact of this disease. Currently, the most common method of serological diagnosis is fluorescently labeled ELISAs. ELISA-based testing is limited as it typically relies on the detection of a single viral antibody subtype within an individual test sample per ELISA plate, the testing is relatively slow (up to 1 week) and expensive (~$5 per test). A low-cost multiplexed platform capable of detecting several antibody markers related to BRD infections in the same test assay would offer significant economic benefits for routine serological testing. Additionally, rapid on-farm ?cowside? multiplexed diagnostic capabilities would be a major step forward towards more efficient and effective management, control and/or eradication of BRD-associated pathogens. At present there is no electronic field based test for disease diagnostics available commercially for the animal health sector, let alone for BRD. Our team will address these challenges by building inexpensive electrochemical sensors for detection of biomarkers associated with BRD infection.