RUI: Modification and characterization of polymer surfaces with applications in microfluidic neural circuit development

RUI:聚合物表面的改性和表征及其在微流体神经回路开发中的应用

基本信息

  • 批准号:
    1305808
  • 负责人:
  • 金额:
    $ 31.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-06-01 至 2017-05-31
  • 项目状态:
    已结题

项目摘要

TECHNICAL SUMMARYThis Research at Undergraduate Institutions (RUI) project will address developing a fundamental understanding of how certain hydrohalocarbon solvents can be used to activate polymeric surfaces to significantly improve the adhesion of vapor deposited noble metal thin films such as Au and Pt which are technologically important in the microfabrication of sensors and interconnects in polymer microdevices. Work on this project will answer the following broad question: Which range of polymers, solvents and metal interactions can be improved through the creation of a Lewis acid-base adduct between the polymer surface, the organic solvent, and the deposited metal? In order to address this question, a range of experimental and theoretical tools will be used to predict, design and optimize experimental conditions resulting in polymeric surfaces which promote improved metal adhesion. Successful adhesion of Au and Pt thin films have been demonstrated with poly(methyl methacrylate) (PMMA) exposed to a variety of halogenated solvents. Polymer surfaces with a range of similar backbone and side-chain chemistries compared to PMMA will be explored, as will materials that have a different chemical composition, but may exhibit similar Lewis base properties compared to PMMA. The patterning of polymer surfaces will be studied to determine if solvent activation methods can be used in conjunction with soft-lithographic techniques to produce patterned features compatible with microfluidic devices that can be used to simulate neural circuit development and function on a polymer microchip. Materials properties will be studied using a combination of surface analysis and microscopy techniques including X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), attenuated total reflection infrared spectroscopy (ATR-FTIR) and spectroscopic and imaging techniques such as optical and electron microscopy and spectroscopic ellipsometry. NON-TECHNICAL SUMMARYThis Research at Undergraduate Institutions (RUI) project will study the adhesion of metal films onto polymeric surfaces with applications in polymer microdevices. Researchers at James Madison University and the University of Virginia will train undergraduate research students in a highly interdisciplinary and collaborative environment. This project will involve the training of up to fifteen undergraduate researchers over the duration of the program. The students will be exposed to materials science issues of the processing, modification and characterization of polymer thin films, surfaces and interfaces. The students funded in this program will be expected to participate in activities related to the NSF Research Experiences for Undergraduates (REU) site in chemistry at JMU to become part of a "community of scholars" with up to sixty other summer undergraduate researchers each summer in chemistry, physics, engineering and materials science at JMU. They will have further opportunities to interact with graduate researchers in biology through an exchange program with undergraduates from JMU going to UVa for one summer and visa versa. Finally, this program will fund two high school teachers to work in a research environment to learn how materials science can be applied to the secondary school chemistry or physics curriculum. In summary, this program helps serve to broadly impact the pipeline of future scientists from the high school through graduate level with students trained in cutting-edge polymer materials science topics with biological applications of polymer surfaces.
技术总结本研究在本科院校(RUI)的项目将解决如何某些氢卤烃溶剂可以用来激活聚合物表面显着提高气相沉积的贵金属薄膜,如Au和Pt的粘附力,这是技术上重要的传感器和互连在聚合物微器件的微制造的基本认识。该项目的工作将回答以下广泛的问题:通过在聚合物表面、有机溶剂和沉积金属之间形成刘易斯酸碱加合物,可以改善聚合物、溶剂和金属的相互作用范围?为了解决这个问题,一系列的实验和理论工具将被用来预测,设计和优化实验条件,导致聚合物表面,促进改善金属粘附。Au和Pt薄膜的成功粘附已被证明与聚(甲基丙烯酸甲酯)(PMMA)暴露于各种卤化溶剂。将探索与PMMA相比具有一系列相似主链和侧链化学性质的聚合物表面,以及具有不同化学组成但与PMMA相比可能表现出相似刘易斯碱性质的材料。将研究聚合物表面的图案化,以确定溶剂活化方法是否可以与软光刻技术结合使用,以产生与微流体设备兼容的图案化特征,该微流体设备可用于模拟聚合物微芯片上的神经回路开发和功能。材料特性将使用表面分析和显微镜技术的组合进行研究,包括X射线光电子能谱(XPS),原子力显微镜(AFM),衰减全反射红外光谱(ATR-FTIR)和光谱和成像技术,如光学和电子显微镜和光谱椭圆偏振法。非技术性总结本研究在本科院校(RUI)项目将研究金属薄膜在聚合物表面的粘附力,并应用于聚合物微器件。詹姆斯麦迪逊大学和弗吉尼亚大学的研究人员将在高度跨学科和协作的环境中培养本科研究生。该项目将涉及多达15名本科研究人员在该计划的持续时间的培训。学生将接触到聚合物薄膜,表面和界面的加工,改性和表征的材料科学问题。该计划资助的学生将参加与NSF本科生化学研究经验(REU)网站相关的活动,成为“学者社区”的一部分,每年夏天在JMU的化学,物理,工程和材料科学领域有多达60名其他暑期本科研究人员。他们将有更多的机会与生物学研究生进行交流,通过与JMU的本科生进行一个夏天的交流,反之亦然。最后,该计划将资助两名高中教师在研究环境中工作,学习如何将材料科学应用于中学化学或物理课程。总之,该计划有助于广泛影响未来科学家的管道,从高中到研究生水平,学生接受尖端聚合物材料科学主题的培训,并具有聚合物表面的生物应用。

项目成果

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William Hughes其他文献

Maximizing wound coverage in full-thickness skin defects: A randomized-controlled trial of autologous skin cell suspension and widely meshed autograft versus standard autografting
最大化全层皮肤缺损的伤口覆盖:自体皮肤细胞悬浮液和广泛网状自体移植与标准自体移植的随机对照试验
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Sharon Henry;Steven Mapula;Mark A. Grevious;Kevin N. Foster;Herbert Phelan;Jeffrey W Shupp;Rodney Chan;David Harrington;Neil Mashruwala;David A. Brown;Haaris Mir;George Singer;Alfredo C Cordova;Lisa Rae;Theresa L Chin;Lourdes Castanon;Derek Bell;William Hughes;Joseph A. Molnar
  • 通讯作者:
    Joseph A. Molnar
Elizabeth Telfer, Food for Thought: Philosophy and Food
Bilateral anterior compartment syndrome secondary to psychogenic polydipsia
  • DOI:
    10.1007/s00238-022-01939-0
  • 发表时间:
    2022-01-27
  • 期刊:
  • 影响因子:
    0.800
  • 作者:
    William Hughes;Neill McCormack;Claire Cattigan;Damon Thomas;Stephen J. Goldie
  • 通讯作者:
    Stephen J. Goldie
Exosome-Deficient Mutants Reveal Rare Promoter Upstream Transcripts (PROMPTs) in Arabidopsis[OPEN]
  • DOI:
    10.1105/tpc.20.00215
  • 发表时间:
    2020-03
  • 期刊:
  • 影响因子:
    11.6
  • 作者:
    William Hughes
  • 通讯作者:
    William Hughes
Cervical necrotizing fasciitis originating with a periapical infection
  • DOI:
    10.14219/jada.archive.2010.0284
  • 发表时间:
    2010-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Trevor Treasure;William Hughes;Jeffrey Bennett
  • 通讯作者:
    Jeffrey Bennett

William Hughes的其他文献

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{{ truncateString('William Hughes', 18)}}的其他基金

EAGER Germination Renewal: Piloting a Center for Transformative Research at Boise State University
渴望萌芽更新:在博伊西州立大学试点变革研究中心
  • 批准号:
    1745944
  • 财政年份:
    2017
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Standard Grant
EAGER Germination: Aligning Stakeholders and Structures to Enable Risk Taking (ASSERT)
EAGER Germination:协调利益相关者和结构以实现风险承担 (ASSERT)
  • 批准号:
    1629659
  • 财政年份:
    2016
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Standard Grant
SNM: Atomically Precise, Defect Free, DNA Masks with Embedded Metrology
SNM:具有嵌入式计量功能的原子级精确、无缺陷 DNA 掩模
  • 批准号:
    1344915
  • 财政年份:
    2014
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Standard Grant
Development and verification of a standardised protocol for the detection of parasite infection levels in commercially-produced bumblebee colonies
开发和验证商业化生产的大黄蜂群中寄生虫感染水平检测的标准化方案
  • 批准号:
    NE/L002760/1
  • 财政年份:
    2013
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Research Grant
Strength in diversity: the effects of host-parasite genetic diversity on transmission and evolution
多样性的力量:宿主-寄生虫遗传多样性对传播和进化的影响
  • 批准号:
    NE/G006849/2
  • 财政年份:
    2013
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Research Grant
An Interdisciplinary Materials Science REU Program at James Madison University
詹姆斯麦迪逊大学跨学科材料科学 REU 项目
  • 批准号:
    0851367
  • 财政年份:
    2009
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Continuing Grant
Genetic polymorphism for chemical tags in leaf-cutting ants
切叶蚁化学标签的遗传多态性
  • 批准号:
    NE/F011253/1
  • 财政年份:
    2009
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Research Grant
Strength in diversity: the effects of host-parasite genetic diversity on transmission and evolution
多样性的力量:宿主-寄生虫遗传多样性对传播和进化的影响
  • 批准号:
    NE/G006849/1
  • 财政年份:
    2009
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Research Grant
Host resistance and within-host competition between leaf-cutting ant parasites with opposing transmission strategies
具有相反传播策略的切叶蚁寄生虫之间的宿主抵抗和宿主内竞争
  • 批准号:
    NE/F000677/1
  • 财政年份:
    2008
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Research Grant
An Interdisciplinary Materials Research REU Site at James Madison University
詹姆斯麦迪逊大学跨学科材料研究 REU 站点
  • 批准号:
    0353773
  • 财政年份:
    2004
  • 资助金额:
    $ 31.32万
  • 项目类别:
    Continuing Grant

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Characterization of the landscape of STAT1 regulation by oxidative modification of Cysteines to inspire drug design.
通过半胱氨酸氧化修饰来表征 STAT1 调节景观,以启发药物设计。
  • 批准号:
    476703
  • 财政年份:
    2022
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    $ 31.32万
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TRTech-PGR: Identification and characterization of stress-responsive and evolutionary conserved epitranscriptomic modification sites in plant transcriptomes.
TRTech-PGR:植物转录组中胁迫响应和进化保守的表观转录组修饰位点的鉴定和表征。
  • 批准号:
    2023310
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    2020
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    $ 31.32万
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Engineering and characterization of a novel immunomodulatory oncolytic virus via modification of cellular phosphorylation homeostasis
通过改变细胞磷酸化稳态来设计和表征新型免疫调节溶瘤病毒
  • 批准号:
    439698
  • 财政年份:
    2020
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Molecular Basis of Structural Studies, Phytochemical Characterization and Nutritional Evaluation of New Modified Alfalfa (with "HB", "TT8" and "miR156" Genes) Developed through Gene Transformation and Gene Modification in Ruminant Livestock Systems
通过反刍家畜系统中的基因转化和基因修饰开发的新型改良苜蓿(带有“HB”、“TT8”和“miR156”基因)的结构研究、植物化学特征和营养评价的分子基础
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    2019
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    $ 31.32万
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CRII: III: RUI: Effective Protein Characterization via Fast Exact Open Modification Searching
CRII:III:RUI:通过快速精确开放修饰搜索进行有效的蛋白质表征
  • 批准号:
    1850557
  • 财政年份:
    2019
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CRII:III:RUI:通过快速精确开放修饰搜索进行有效的蛋白质表征
  • 批准号:
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Modification and Characterization of Oclansorb® for Oil Spill Cleanup
用于溢油清理的 Oclansorb® 的改性和表征
  • 批准号:
    538830-2019
  • 财政年份:
    2019
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    $ 31.32万
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Clinicopathological and molecular characterization of bone and soft tissue tumors with aberrant histone modification
组蛋白修饰异常的骨和软组织肿瘤的临床病理学和分子特征
  • 批准号:
    18K15110
  • 财政年份:
    2018
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Molecular Basis of Structural Studies, Phytochemical Characterization and Nutritional Evaluation of New Modified Alfalfa (with "HB", "TT8" and "miR156" Genes) Developed through Gene Transformation and Gene Modification in Ruminant Livestock Systems
通过反刍家畜系统中的基因转化和基因修饰开发的新型改良苜蓿(带有“HB”、“TT8”和“miR156”基因)的结构研究、植物化学特征和营养评价的分子基础
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Characterization of a novel metal surface modification for enhanced convective heat transfer
用于增强对流换热的新型金属表面改性的表征
  • 批准号:
    530264-2018
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