Collaborative Research: Development of Novel Nonlinear Optical Contrast for High-Resolution Morphological and Chemical Imaging of Historical Artwork

合作研究：开发用于历史艺术品高分辨率形态和化学成像的新型非线性光学对比度

• 批准号: 1307098
• 负责人: Robert Opila
• 金额: $ 7.81万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307098&HistoricalAwards=false
• 关键词: Collaborative; Research; Development; Novel; Nonlinear

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Instrument Development for Biological Research (IDBR) program in the Division of Biological Infrastructure (DBI), Professors Martin Fischer, Warren Warren, Robert Opila, Dr. Jennifer Mass and their groups will develop a novel imaging method for nondestructive identification and high-resolution, three-dimensional mapping of both tissue and a broad range of pigment samples in historic works of art. The primary focus of the proposed research will be to set up a multimodal nonlinear optical microscope for noninvasive, high-resolution imaging and use pulse shaping and time-resolved detection technology for simultaneous access to absorptive and refractive contrasts and further develop novel analysis and characterization methods for tissue samples and pigments. The groups will then set up three-dimensional (3D) imaging of thick tissue, paint cross-sections and intact historic paintings and further increase imaging depth for molecular absorption and nonlinear phase contrast. The researchers will develop a portable microscope for applications in the field and the core technology developed will then be disseminated through industrial partners.The proposed research, if successful, will enable in situ applications in a conservation setting to avoid having to remove artworks from their climate-controlled environment, which will dramatically impact conservation science by providing a non-invasive imaging modality that can extract comprehensive structural and chemical information from historic artwork, complementing established mapping techniques. The technology developed will also provide tools to the broad biology community to examine structural, metabolic and functional contrast in biological tissue. The program will provide training opportunities in an interdisciplinary environment spanning conservation science, art history, physics, chemistry, biology, and engineering for graduate, undergraduate, and high-school students.

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Instrument Development for Biological Research (IDBR) program in the Division of Biological Infrastructure (DBI), Professors Martin Fischer, Warren Warren, Robert Opila, Dr. Jennifer Mass and their groups will develop a novel imaging method for nondestructive identification and high-resolution, three-dimensional mapping of both tissue and a broad range of pigment samples在历史艺术品中。 拟议研究的主要重点是建立用于非侵入性，高分辨率成像的多模式非线性光学显微镜，并使用脉冲成型和时间分辨的检测技术，以同时访问吸收性和折射性对比度，并进一步开发用于组织和颜料的新颖分析和表征分析和表征。然后，这些组将对厚组织，油漆横截面和完整的历史绘画进行三维（3D）成像，并进一步增加成像深度以进行分子吸收和非线性相对比。研究人员将开发用于该领域应用的便携式显微镜，然后开发的核心技术将通过工业合作伙伴进行分散。拟议的研究（如果成功）将在保护环境中启用现场应用，以避免必须从其气候控制的环境中删除艺术品，从而从其气候控制的环境中删除艺术品，从而通过提供无效的构建技术来促进构建的构建，从而可以融合了融合的模式，从而可以融合了融合的模式，并将其融合为化学的融合，并将其备受融合的化学融合性的化学融合性，并能够通过融合的构建方式来消除融合的构建，并将其置于融合性的化学范围内。映射技术。 开发的技术还将为广泛的生物学社区提供工具，以检查生物组织中的结构，代谢和功能对比。该计划将在跨学科环境中提供培训机会，该环境涵盖研究生，本科生和高中生的保护科学，艺术史，物理，化学，生物学和工程学。