Collaborative Research: Development of Novel Nonlinear Optical Contrast for High-Resolution Morphological and Chemical Imaging of Historical Artwork

合作研究：开发用于历史艺术品高分辨率形态和化学成像的新型非线性光学对比度

• 批准号: 1307098
• 负责人: Robert Opila
• 金额: $ 7.81万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307098&HistoricalAwards=false
• 关键词: Collaborative; Research; Development; Novel; Nonlinear

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Instrument Development for Biological Research (IDBR) program in the Division of Biological Infrastructure (DBI), Professors Martin Fischer, Warren Warren, Robert Opila, Dr. Jennifer Mass and their groups will develop a novel imaging method for nondestructive identification and high-resolution, three-dimensional mapping of both tissue and a broad range of pigment samples in historic works of art. The primary focus of the proposed research will be to set up a multimodal nonlinear optical microscope for noninvasive, high-resolution imaging and use pulse shaping and time-resolved detection technology for simultaneous access to absorptive and refractive contrasts and further develop novel analysis and characterization methods for tissue samples and pigments. The groups will then set up three-dimensional (3D) imaging of thick tissue, paint cross-sections and intact historic paintings and further increase imaging depth for molecular absorption and nonlinear phase contrast. The researchers will develop a portable microscope for applications in the field and the core technology developed will then be disseminated through industrial partners.The proposed research, if successful, will enable in situ applications in a conservation setting to avoid having to remove artworks from their climate-controlled environment, which will dramatically impact conservation science by providing a non-invasive imaging modality that can extract comprehensive structural and chemical information from historic artwork, complementing established mapping techniques. The technology developed will also provide tools to the broad biology community to examine structural, metabolic and functional contrast in biological tissue. The program will provide training opportunities in an interdisciplinary environment spanning conservation science, art history, physics, chemistry, biology, and engineering for graduate, undergraduate, and high-school students.

在化学部化学测量和成像项目以及生物基础设施部 (DBI) 生物研究仪器开发 (IDBR) 项目的支持下，Martin Fischer、Warren Warren、Robert Opila、Jennifer Mass 博士及其团队将开发一种新颖的成像方法，用于组织和各种色素样本的无损识别和高分辨率三维绘图 在历史艺术作品中。 拟议研究的主要重点将是建立一种用于非侵入性高分辨率成像的多模态非线性光学显微镜，并使用脉冲整形和时间分辨检测技术来同时获取吸收和折射对比度，并进一步开发组织样本和色素的新颖分析和表征方法。然后，这些小组将对厚组织、油漆横截面和完整的历史绘画进行三维 (3D) 成像，并进一步增加分子吸收和非线性相位对比的成像深度。研究人员将开发一种用于现场应用的便携式显微镜，所开发的核心技术将通过工业合作伙伴进行传播。拟议的研究如果成功，将能够在保护环境中进行原位应用，以避免将艺术品从气候控制的环境中移走，这将通过提供一种非侵入性成像方式来极大地影响保护科学，该方式可以从历史艺术品中提取全面的结构和化学信息，补充现有的技术 测绘技术。 所开发的技术还将为广泛的生物学界提供工具来检查生物组织的结构、代谢和功能对比。该项目将为研究生、本科生和高中生提供跨学科环境的培训机会，涵盖保护科学、艺术史、物理、化学、生物学和工程学。