Homochiral Crystalline Porous Materials for Enantioselective Applications

技术概述：这项拟议的研究由材料研究部的固态和材料化学计划支持，旨在开发新的合成方法，以创建用于对映选择性应用的晶态同手性多孔材料。虽然通过引入手性结构构建块来合成这类材料已经取得了重大进展，但从非手性构建块合成此类材料仍然具有挑战性，但仍具有非常重要的意义。所提出的手性诱导方法寻求从不同的非手性结构单元构建均手性多孔材料，同时通过使用廉价且通常是自然生成的对映体手性诱导剂(CIA)来控制绝对手性。该项目还将研究金属-CIA相互作用，以揭示可用于手性和对映体控制的新机制。一系列低成本的有机和生物分子CIA将在不同的合成条件下进行研究，以了解它们在多孔骨架结晶过程中的作用。新的同手性多孔材料将通过研究它们的晶体结构、孔隙率和表面积、热稳定性和化学稳定性以及对映体选择性来表征。非技术概述：拟议的活动主要在一个本科院校进行，旨在引入新的合成概念和方法，可以用来创建作为催化剂和吸附剂的同手性多孔材料，用于制备高度有用的化学品和药物。拟议的研究包括从化学合成、自组装和晶体生长到晶体结构分析和性能表征的各种研究活动。它将导致具有潜在技术应用的新功能材料的创造，并大大加强对固体材料的合成和结构化学的理解。PI旨在通过建立一个非常有趣和重要的研究计划来促进学生的教学和培训，并通过发展最先进的综合和工具能力来扩大具有不同文化背景的本科生和研究生的学习机会和参与。

TECHNICAL SUMMARY: The proposed research, supported by the Solid State and Materials Chemistry program in the Division of Materials Research, aims to develop new synthetic methods for the creation of crystalline homochiral porous materials for enantioselective applications. While significant progress has been made in the synthesis of such materials by incorporating chiral structural building blocks, their synthesis from nonchiral building blocks remains challenging, and yet highly important. The proposed chirality induction method seeks to construct homochiral porous materials from diverse nonchiral building units while controlling absolute chirality by using inexpensive and often naturally occurring enantiopure chiral induction agents (CIA). The project will also study the metal-CIA interactions to uncover new mechanisms that can be utilized for the chirality and enantiopurity control. A range of low-cost organic and biomolecular CIAs will be studied under various synthetic conditions for their effects during crystallization of porous frameworks. New homochiral porous materials will be characterized by studying their crystal structures, porosity and surface area, thermal and chemical stability, and enantioselectivity.NON-TECHNICAL SUMMARY: The proposed activity, conducted at a Primarily Undergraduate Institution, seeks to introduce new synthetic concepts and methods that can be employed to create homochiral porous materials as catalysts and adsorbents for the preparation of highly useful chemicals and pharmaceuticals. The proposed research integrates a variety of research activities ranging from chemical synthesis, self-assembly and crystal growth, to crystal structure analysis and property characterizations. It will lead to the creation of new functional materials with potential technological applications and a much-enhanced understanding of synthetic and structural chemistry of solid-state materials. The PI seeks to promote teaching and training of students by establishing a highly interesting and important research program and by developing the state-of-the-art synthetic and instrumental capability to broaden learning opportunities and participation of both undergraduate and graduate students with diverse cultural backgrounds.