Homochiral Crystalline Porous Materials for Enantioselective Applications

技术摘要：拟议的研究得到了材料研究部固态和材料化学项目的支持，旨在开发新的合成方法来创建用于对映选择性应用的结晶同手性多孔材料。虽然通过掺入手性结构单元在合成此类材料方面取得了重大进展，但从非手性结构单元合成它们仍然具有挑战性，但非常重要。所提出的手性诱导方法旨在从不同的非手性结构单元构建同手性多孔材料，同时通过使用廉价且通常天然存在的对映纯手性诱导剂（CIA）来控制绝对手性。该项目还将研究金属-CIA 相互作用，以揭示可用于手性和对映纯度控制的新机制。将在各种合成条件下研究一系列低成本有机和生物分子 CIA 在多孔框架结晶过程中的影响。新的同手性多孔材料将通过研究其晶体结构、孔隙率和表面积、热稳定性和化学稳定性以及对映选择性来表征。非技术摘要：拟议的活动在一个主要本科院校进行，旨在引入新的合成概念和方法，可用于创建同手性多孔材料作为催化剂和吸附剂，用于制备高度有用的化学品和药物。拟议的研究整合了从化学合成、自组装和晶体生长到晶体结构分析和性质表征的各种研究活动。它将导致创造具有潜在技术应用的新型功能材料，并加深对固态材料的合成和结构化学的理解。 PI 致力于通过建立一个非常有趣和重要的研究项目，并通过发展最先进的综合和工具能力来扩大具有不同文化背景的本科生和研究生的学习机会和参与，从而促进学生的教学和培训。

TECHNICAL SUMMARY: The proposed research, supported by the Solid State and Materials Chemistry program in the Division of Materials Research, aims to develop new synthetic methods for the creation of crystalline homochiral porous materials for enantioselective applications. While significant progress has been made in the synthesis of such materials by incorporating chiral structural building blocks, their synthesis from nonchiral building blocks remains challenging, and yet highly important. The proposed chirality induction method seeks to construct homochiral porous materials from diverse nonchiral building units while controlling absolute chirality by using inexpensive and often naturally occurring enantiopure chiral induction agents (CIA). The project will also study the metal-CIA interactions to uncover new mechanisms that can be utilized for the chirality and enantiopurity control. A range of low-cost organic and biomolecular CIAs will be studied under various synthetic conditions for their effects during crystallization of porous frameworks. New homochiral porous materials will be characterized by studying their crystal structures, porosity and surface area, thermal and chemical stability, and enantioselectivity.NON-TECHNICAL SUMMARY: The proposed activity, conducted at a Primarily Undergraduate Institution, seeks to introduce new synthetic concepts and methods that can be employed to create homochiral porous materials as catalysts and adsorbents for the preparation of highly useful chemicals and pharmaceuticals. The proposed research integrates a variety of research activities ranging from chemical synthesis, self-assembly and crystal growth, to crystal structure analysis and property characterizations. It will lead to the creation of new functional materials with potential technological applications and a much-enhanced understanding of synthetic and structural chemistry of solid-state materials. The PI seeks to promote teaching and training of students by establishing a highly interesting and important research program and by developing the state-of-the-art synthetic and instrumental capability to broaden learning opportunities and participation of both undergraduate and graduate students with diverse cultural backgrounds.