GOALI: Research and development of chip-integrated, magnetic-resonance-based platforms for chemical sensing of trace systems and nuclear polarization of fluids

目标：研究和开发基于磁共振的芯片集成平台，用于痕量系统的化学传感和流体的核极化

• 批准号: 1309640
• 负责人: Carlos Meriles
• 金额: $ 42.54万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1309640&HistoricalAwards=false
• 关键词: GOALI; Research; development; chip; integrated

With this GOALI (Grant Opportunities for Academic Liaison with Industry) award from the Chemical Measurements and Imaging program in the Chemistry Division and the Office of Multidisciplinary Activities in the Mathematics and Physical Sciences Directorate, Professors Carlos Meriles at the City College of New York (CCNY) and Orlando Auciello of the University of Texas at Dallas and their students will partner with investigators at Advanced Diamond Technologies, Inc. (ADT), Romeoville, IL to perform basic and applied research and development of novel technologies that exploit the properties of near-surface paramagnetic defects in diamond. The project will combine crystal growth techniques, spin control schemes, and microfluidics and molecular labeling technology to develop chip-integrated structures where a target analyte is brought in contact with paramagnetic centers -- specifically nitrogen-vacancy (NV) centers and substitutional nitrogen -- generated near the surface of ultra-pure diamond. The central goal is to use the paramagnetic centers as sensitive probes tailored to detect the presence of pre-defined trace materials in solution. The research plan includes a range of proof-of-principle experiments explicitly conceived to facilitate the transfer of these sensing technologies to the market. The basic and applied science to be performed and the systems that will ensue are likely to find broad use ranging from chemical analysis and medical diagnostics, to bio-defense, environmental monitoring, and food safety.Magnetic resonance (MR) measurements are well known for the usefulness in medical imaging, but a close variant of these measurements are widely used in chemical analysis because they provide a wealth of information about sample composition and molecular structure. However, the detection limits of MR measurements are typically too high for use in trace analyses, such as environmental monitoring and medical diagnostics. This project will seek to lower the detection limits of MR measurements by coupling the target molecule to tags that produce very strong MR signals as they interact with deliberately induced defects in diamond films. Besides the technological and scientific advantages, this project will enrich the education of PhD students and postdocs through training in entrepreneurship and new venture creation. To meet this goal, the investigators plan various activities that build on the close ties to their industrial collaborator ADT, a company presently commercializing a new generation of industrial and biodevices based on exclusive thin-film diamond technology. The proposed R&D program includes internships for students and postdocs under the combined supervision of an academic mentor and an industry partner, student-oriented seminars by lead industrial scientists, and regular cyber-enabled interactions designed to facilitate the transfer of research results to industry. These plans gain special meaning at CCNY and UTD, two institutions with a large population of minority students. Capitalizing on the various recruitment channels at hand, the teaching, mentoring and career counseling components of this project will truly broaden participation, while encouraging groups underrepresented in the sciences to pursue scientific careers both in academia and industry.

有了这个目标（与工业界学术联络的赠款机会）奖，从化学部和数学和物理科学理事会多学科活动办公室的化学测量和成像计划，教授卡洛斯Meriles在纽约城市学院（CCNY）和得克萨斯大学达拉斯的奥兰多Auciello和他们的学生将与先进的钻石技术，Inc. (ADT)，伊利诺伊州的科洛威尔，进行基础和应用研究和开发的新技术，利用金刚石近表面顺磁缺陷的性质。该项目将结合联合收割机晶体生长技术，自旋控制方案，微流体和分子标记技术来开发芯片集成结构，其中目标分析物与顺磁中心接触-特别是氮空位（NV）中心和取代氮-在超纯金刚石表面附近产生。中心目标是使用顺磁中心作为灵敏的探针，用于检测溶液中预定义的痕量物质的存在。该研究计划包括一系列明确设想的原理验证实验，以促进这些传感技术向市场的转移。要执行的基础和应用科学以及将随之而来的系统可能会发现从化学分析和医学诊断到生物防御、环境监测和食品安全的广泛用途。磁共振（MR）测量因其在医学成像中的有用性而众所周知，但是这些测量的近似变体广泛用于化学分析，因为它们提供了关于样品组成和分子结构的丰富信息。然而，MR测量的检测极限通常太高而不能用于痕量分析，例如环境监测和医疗诊断。 该项目将寻求通过将目标分子与标签耦合来降低MR测量的检测限，这些标签在与金刚石膜中故意诱导的缺陷相互作用时产生非常强的MR信号。 除了技术和科学优势外，该项目还将通过创业和新企业创建培训丰富博士生和博士后的教育。为了实现这一目标，研究人员计划开展各种活动，这些活动建立在与他们的工业合作伙伴ADT的密切联系之上，ADT是一家目前正在商业化基于独家薄膜金刚石技术的新一代工业和生物设备的公司。拟议的研发计划包括在学术导师和行业合作伙伴的联合监督下为学生和博士后提供实习机会，由领先的工业科学家举办以学生为导向的研讨会，以及旨在促进研究成果向行业转移的定期网络互动。这些计划在CCNY和UTD获得特殊的意义，这两个机构拥有大量的少数民族学生。利用手头的各种招聘渠道，该项目的教学，辅导和职业咨询部分将真正扩大参与，同时鼓励科学界代表性不足的群体在学术界和工业界追求科学事业。

项目成果

Nuclear spin temperature reversal via continuous radio-frequency driving

通过连续射频驱动实现核自旋温度逆转

• DOI: 10.1103/physrevb.103.085205
• 发表时间: 2021
• 期刊: Physical Review B
• 影响因子: 3.7
• 作者: Zangara, Pablo R.;Pagliero, Daniela;Ajoy, Ashok;Acosta, Rodolfo H.;Reimer, Jeffrey A.;Meriles, Carlos A.
• 通讯作者: Meriles, Carlos A.