CAREER: Understanding Process-Induced Damage in Laser-Assisted Cell Direct Writing - Bridging Manufacturing Science and Biomedical Research

职业:了解激光辅助细胞直写过程中引起的损伤 - 连接制造科学和生物医学研究

基本信息

  • 批准号:
    1321271
  • 负责人:
  • 金额:
    $ 15.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-01-01 至 2014-09-30
  • 项目状态:
    已结题

项目摘要

The research objective of this Faculty Early Career Development (CAREER) Program project is to elucidate the effects of process-induced thermomechanical loading magnitude and duration on cell damage in laser-assisted living cell direct writing. Using a laser-assisted living cell direct-write technology, this research will 1) model the process-induced thermomechanical loading magnitude and duration during cell droplet formation and landing processes; 2) model the cell post-transfer viability by understanding the mechanistic correlation between cell damage/viability and process-induced thermomechanical loading magnitude and duration; and 3) calibrate and validate the mechanistic cell viability model based on cell death measurements. The educational objective is to promote engineering through biomedical manufacturing innovations. Key education activities include providing outreach to high school students through an e-museum, Machining the Body: Young Machinist, including a Young Investigator Video series and developing and disseminating educational materials for high education in biomedical manufacturing.If successful, this study will contribute towards an understanding of the dynamics of laser-assisted cell droplet formation and landing processes and the effects of process-induced thermomechanical loading on cell damage/viability. The resulting mechanistic cell viability model will elucidate an understanding of process-induced cell damage caused by jet-based direct writing. Broader impacts of this study are multifaceted. The safe and efficient implementation of cell direct writing enables its wide application in both organ printing and rapid prototyping of cell-based products. Society will benefit from these new on-demand organ manufacturing and cell seeding-related health technologies, and this study will foster research collaboration between manufacturing science and biomedical research. The integration of education with biomedical manufacturing research will attract underrepresented and minority students and promote engineering to a broader population.
本学院早期职业发展(CAREER)计划项目的研究目标是阐明激光辅助活细胞直写中过程诱导的热机械负载幅度和持续时间对细胞损伤的影响。利用激光辅助活细胞直写技术,本研究将1)模拟细胞液滴形成和着陆过程中的过程诱导的热机械载荷大小和持续时间; 2)通过理解细胞损伤/存活率与过程诱导的热机械载荷大小和持续时间之间的机械相关性来模拟细胞转移后的存活率;以及3)基于细胞死亡测量来校准和验证机械细胞存活力模型。教育目标是通过生物医学制造创新促进工程。主要的教育活动包括通过一个电子博物馆向高中生提供外展服务,该博物馆名为“加工身体:青年机械师,包括一个青年调查员视频系列,并为生物医学制造业的高等教育开发和传播教育材料。这项研究将有助于了解激光辅助细胞液滴形成和着陆过程的动力学以及过程的影响,诱导的热机械负荷对细胞损伤/活力的影响。由此产生的机械细胞活力模型将阐明由基于喷射的直接写入引起的过程诱导的细胞损伤的理解。这项研究的更广泛影响是多方面的。细胞直写的安全和高效实现使其在器官打印和基于细胞的产品的快速原型制作中得到广泛应用。社会将受益于这些新的按需器官制造和细胞接种相关的健康技术,这项研究将促进制造科学和生物医学研究之间的研究合作。将教育与生物医学制造研究相结合将吸引代表性不足的少数民族学生,并将工程学推广到更广泛的人群。

项目成果

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Yong Huang其他文献

Navigation of Chang’E-2 asteroid exploration mission and the minimum distance estimation during its fly-by of Toutatis
嫦娥二号小行星探测任务导航及飞越图塔蒂斯过程中的最小距离估算
  • DOI:
    10.1016/j.asr.2014.10.005
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Jianfeng Cao;Yong Liu;Songjie Hu;Lei Liu;Geshi Tang;Yong Huang;Peijia Li
  • 通讯作者:
    Peijia Li
Simulation of groundwater flow in fractured rocks using a coupled model based on the method of domain decomposition
基于域分解方法的耦合模型模拟裂隙岩体中地下水流
  • DOI:
    10.1007/s12665-014-3184-y
  • 发表时间:
    2014-03
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Yong Huang;Zhifang Zhou;Jinguo Wang;Zhi Dou
  • 通讯作者:
    Zhi Dou
Effect of UV-B on growth and development and secondary metabolism of flue-cured tobacco: Effect of UV-B on growth and development and secondary metabolism of flue-cured tobacco
UV-B对烤烟生长发育和次生代谢的影响: UV-B对烤烟生长发育和次生代谢的影响
  • DOI:
    10.3724/sp.j.1011.2009.00140
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yong Huang;Ji;Mingmei Zheng;Hong;Ning Zhang
  • 通讯作者:
    Ning Zhang
Dielectric properties of hybrid perovskites and drift-diffusion modeling of perovskite cells
混合钙钛矿的介电特性和钙钛矿细胞的漂移扩散建模
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    L. Pédesseau;M. Képénekian;D. Sapori;Yong Huang;A. Rolland;Alexandre Beck;C. Cornet;O. Durand;Shijian Wang;C. Katan;J. Even
  • 通讯作者:
    J. Even
Does aggressiveness help? Evidence from IPO corruption and pricing in China
攻击性有帮助吗?
  • DOI:
    10.1016/j.jcorpfin.2021.101901
  • 发表时间:
    2021-04
  • 期刊:
  • 影响因子:
    6.1
  • 作者:
    Yong Huang;Chao Yan;Kam C. Chan
  • 通讯作者:
    Kam C. Chan

Yong Huang的其他文献

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{{ truncateString('Yong Huang', 18)}}的其他基金

Pore Formation and Polymer Thermal Debinding during Vapor-Induced Phase Separation-Enabled Metal Printing
蒸汽诱导相分离金属打印过程中的孔形成和聚合物热脱脂
  • 批准号:
    2315811
  • 财政年份:
    2023
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
EAGER: 3D Printing of Aligned Muscle Fibers for Thick Structured Meat Production
EAGER:用于厚结构肉生产的对齐肌肉纤维的 3D 打印
  • 批准号:
    2233814
  • 财政年份:
    2022
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Manufacturing USA: Study of Self-Supporting Nanoclay as Internal Scaffold Material for Printing of Skeletal Tissue Constructs
美国制造:自支撑纳米粘土作为骨骼组织结构打印内部支架材料的研究
  • 批准号:
    1762941
  • 财政年份:
    2018
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
GOALI: Printing of Heterogeneous Tissue Constructs from Reactive Biomaterials using Intersecting Jets
GOALI:使用相交喷射机打印反应性生物材料的异质组织结构
  • 批准号:
    1634755
  • 财政年份:
    2016
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Scalable Laser Printing of Three-Dimensional Living Tissue Constructs
三维活组织结构的可扩展激光打印
  • 批准号:
    1537956
  • 财政年份:
    2015
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Workshop: Environmental Implications of Additive Manufacturing; Arlington, Virginia; October 14-15, 2014
研讨会:增材制造的环境影响;
  • 批准号:
    1450529
  • 财政年份:
    2014
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Collaborative Research: Understanding Machining-Induced Influences to Ultra-Fine Grained Pure Titanium for Biomedical Applications
合作研究:了解机械加工对生物医学应用超细晶纯钛的影响
  • 批准号:
    1404926
  • 财政年份:
    2014
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
NSF Workshop on Frontiers of Additive Manufacturing Research and Education; Arlington, Virginia; 11-12 July 2013
NSF 增材制造研究和教育前沿研讨会;
  • 批准号:
    1339027
  • 财政年份:
    2013
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Fabrication of Double-Layer Cellular Spheroid using Acoustic Excitation-Assisted Compound Jetting
使用声激励辅助复合喷射制备双层细胞球体
  • 批准号:
    1314834
  • 财政年份:
    2013
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant
Collaborative Research: Laser-Assisted Orifice-Free Fabrication of Viscous Alginate Microspheres
合作研究:激光辅助无孔制造粘性海藻酸盐微球
  • 批准号:
    1314830
  • 财政年份:
    2013
  • 资助金额:
    $ 15.18万
  • 项目类别:
    Standard Grant

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