Collaborative Research: Laser-Assisted Orifice-Free Fabrication of Viscous Alginate Microspheres
合作研究:激光辅助无孔制造粘性海藻酸盐微球
基本信息
- 批准号:1314830
- 负责人:
- 金额:$ 31.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2017-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of this collaborative study is to test the hypothesis that encapsulated microspheres with a uniform size can be controllably fabricated from a highly viscous fluid system using a novel process not based on the use of an orifice. Orifice-based techniques limit the flexibility in rapidly producing different size microspheres from viscous fluids. The laser-assisted orifice-free fabrication technique, utilizing a metallic foil as the dynamic release layer, will be especially suitable for fluids with a viscosity on the order of 100 mPa's or higher. Key research activities include 1) demonstrating and optimizing the proposed laser-assisted forward transfer technique using the process dynamics knowledge gained from a time-resolved imaging study and mathematical modeling; and 2) elucidating the fluid dynamics of the laser-assisted fabrication of encapsulated microspheres. Sodium alginate will be used as a model fluid to encapsulate living cells. In particular, rat endothelial cell suspension will be added to the sodium alginate solutions as a representative active ingredient to be encapsulated. The fabricated microspheres will be experimentally evaluated in terms of physical and biological properties.Success in this research will expand the knowledge for viscous microsphere fabrication using metallic-foil assisted laser forward transfer. The precise control of viscous encapsulated microsphere size is of great manufacturing importance since the size distribution can determine the success in most microsphere applications such as tissue engineering and drug delivery. Broader impacts also will include a pipeline of well-trained students ready to undertake careers in Science, Technology, Engineering, and Mathematics disciplines. With the new knowledge gained from this study, Biomedical Manufacturing and Processing of Biomaterials courses will be further developed to expose students to state-of-the-art advances in manufacturing technologies.
这项合作研究的目的是测试的假设,具有均匀尺寸的封装微球可以可控地制造从一个高粘度的流体系统,使用一种新的方法,而不是基于使用的孔。基于孔的技术限制了从粘性流体快速生产不同尺寸微球的灵活性。利用金属箔作为动态释放层的激光辅助无摩擦制造技术将特别适用于粘度为100 mPa·s或更高的流体。主要研究活动包括:1)使用从时间分辨成像研究和数学建模中获得的过程动力学知识,演示和优化拟议的激光辅助前向转移技术; 2)阐明激光辅助制造封装微球的流体动力学。海藻酸钠将被用作包封活细胞的模型流体。特别地,将大鼠内皮细胞悬浮液作为待包封的代表性活性成分添加到海藻酸钠溶液中。本研究的成功将为利用金属箔辅助的激光前向转移技术制备粘性微球提供新的思路。粘性封装微球尺寸的精确控制在制造中具有重要意义,因为尺寸分布可以决定大多数微球应用(例如组织工程和药物递送)的成功。更广泛的影响还将包括一个训练有素的学生准备从事科学,技术,工程和数学学科的职业管道。随着从这项研究中获得的新知识,生物医学制造和生物材料加工课程将进一步发展,让学生接触到最先进的制造技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yong Huang其他文献
Navigation of Chang’E-2 asteroid exploration mission and the minimum distance estimation during its fly-by of Toutatis
嫦娥二号小行星探测任务导航及飞越图塔蒂斯过程中的最小距离估算
- DOI:
10.1016/j.asr.2014.10.005 - 发表时间:
2015 - 期刊:
- 影响因子:2.6
- 作者:
Jianfeng Cao;Yong Liu;Songjie Hu;Lei Liu;Geshi Tang;Yong Huang;Peijia Li - 通讯作者:
Peijia Li
Simulation of groundwater flow in fractured rocks using a coupled model based on the method of domain decomposition
基于域分解方法的耦合模型模拟裂隙岩体中地下水流
- DOI:
10.1007/s12665-014-3184-y - 发表时间:
2014-03 - 期刊:
- 影响因子:2.8
- 作者:
Yong Huang;Zhifang Zhou;Jinguo Wang;Zhi Dou - 通讯作者:
Zhi Dou
Effect of UV-B on growth and development and secondary metabolism of flue-cured tobacco: Effect of UV-B on growth and development and secondary metabolism of flue-cured tobacco
UV-B对烤烟生长发育和次生代谢的影响: UV-B对烤烟生长发育和次生代谢的影响
- DOI:
10.3724/sp.j.1011.2009.00140 - 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Yong Huang;Ji;Mingmei Zheng;Hong;Ning Zhang - 通讯作者:
Ning Zhang
Dielectric properties of hybrid perovskites and drift-diffusion modeling of perovskite cells
混合钙钛矿的介电特性和钙钛矿细胞的漂移扩散建模
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
L. Pédesseau;M. Képénekian;D. Sapori;Yong Huang;A. Rolland;Alexandre Beck;C. Cornet;O. Durand;Shijian Wang;C. Katan;J. Even - 通讯作者:
J. Even
Does aggressiveness help? Evidence from IPO corruption and pricing in China
攻击性有帮助吗?
- DOI:
10.1016/j.jcorpfin.2021.101901 - 发表时间:
2021-04 - 期刊:
- 影响因子:6.1
- 作者:
Yong Huang;Chao Yan;Kam C. Chan - 通讯作者:
Kam C. Chan
Yong Huang的其他文献
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{{ truncateString('Yong Huang', 18)}}的其他基金
Pore Formation and Polymer Thermal Debinding during Vapor-Induced Phase Separation-Enabled Metal Printing
蒸汽诱导相分离金属打印过程中的孔形成和聚合物热脱脂
- 批准号:
2315811 - 财政年份:2023
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
EAGER: 3D Printing of Aligned Muscle Fibers for Thick Structured Meat Production
EAGER:用于厚结构肉生产的对齐肌肉纤维的 3D 打印
- 批准号:
2233814 - 财政年份:2022
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
Manufacturing USA: Study of Self-Supporting Nanoclay as Internal Scaffold Material for Printing of Skeletal Tissue Constructs
美国制造:自支撑纳米粘土作为骨骼组织结构打印内部支架材料的研究
- 批准号:
1762941 - 财政年份:2018
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
GOALI: Printing of Heterogeneous Tissue Constructs from Reactive Biomaterials using Intersecting Jets
GOALI:使用相交喷射机打印反应性生物材料的异质组织结构
- 批准号:
1634755 - 财政年份:2016
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
Scalable Laser Printing of Three-Dimensional Living Tissue Constructs
三维活组织结构的可扩展激光打印
- 批准号:
1537956 - 财政年份:2015
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
Workshop: Environmental Implications of Additive Manufacturing; Arlington, Virginia; October 14-15, 2014
研讨会:增材制造的环境影响;
- 批准号:
1450529 - 财政年份:2014
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
Collaborative Research: Understanding Machining-Induced Influences to Ultra-Fine Grained Pure Titanium for Biomedical Applications
合作研究:了解机械加工对生物医学应用超细晶纯钛的影响
- 批准号:
1404926 - 财政年份:2014
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
CAREER: Understanding Process-Induced Damage in Laser-Assisted Cell Direct Writing - Bridging Manufacturing Science and Biomedical Research
职业:了解激光辅助细胞直写过程中引起的损伤 - 连接制造科学和生物医学研究
- 批准号:
1321271 - 财政年份:2013
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
NSF Workshop on Frontiers of Additive Manufacturing Research and Education; Arlington, Virginia; 11-12 July 2013
NSF 增材制造研究和教育前沿研讨会;
- 批准号:
1339027 - 财政年份:2013
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
Fabrication of Double-Layer Cellular Spheroid using Acoustic Excitation-Assisted Compound Jetting
使用声激励辅助复合喷射制备双层细胞球体
- 批准号:
1314834 - 财政年份:2013
- 资助金额:
$ 31.68万 - 项目类别:
Standard Grant
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