NSF/FDA SIR: Performance Assessment of Near-Infrared Spectroscopy Devices for Cerebral Oximetry: Dynamic Test Methods and Light-Tissue Interactions

1343641 Chen该NSF/FDA驻校学者提案的目的是推进基于体模的测试方法和计算工具的开发，以阐明和评估新型NIR血氧仪的性能。这将涉及：1）便携式NIRS系统的开发和验证; 2）IEC/ISO fNIRS标准草案中规定的主要体模材料的组织光学特性的表征及其作为组织模拟体模基质材料的使用的评估，基于具有血管样内含物的均质平板和样品; 3）基于获得的血管网络体积的3D打印体模的开发;（4）建立了基于血管网络体积的三维光传播模型，研究了设备参数和组织参数对采样灵敏度的影响。

1343641ChenThe objective of this NSF/FDA Scholar-in-Residence proposal is to advance the development of phantom-based test methods and computational tools for elucidating and evaluating the performance of novel NIR oximetry devices. This will involve: 1) Development and validation of a portable NIRS system; 2) Characterization of the tissue optics of the main phantom material specified in the IEC/ISO fNIRS draft standard and evaluation of its use as a matrix material for tissue-simulating phantoms, based on homogeneous slabs and samples with vessel-like inclusions; 3) Development of 3D printed phantoms based on the acquired vascular network volume; and 4) Development and implementation of a 3D model of light propagation based on the vascular network volume to study the effect of device and tissue parameters onsampling sensitivity.