CAREER: Biomolecular Detection at Polarized Luquid-Liquid Interfaces

1351253-Gagnon这项教职早期职业发展(Career)计划拨款的总体目标是开发廉价和便携的生物传感器，用于快速、灵敏和特定的无标记多路生物分子检测。小型化的生物传感系统使用少量昂贵的试剂和珍贵的样本，为患者和医生提供更快的分析，并且不需要训练有素的技术人员操作，这种可能性在发展中国家的疾病预防、生物医学/反恐应用、环境监测、护理点诊断测试和基础生物学研究中立即得到应用。实现这一目标的一个主要障碍是缺乏快速、灵敏和专用于小浓度目标生物分子的可用的生物传感器，而不需要标记探针或光学显微镜，并且可以在不需要复杂和笨重的辅助仪器的情况下操作。该项目将通过开发用于液体界面生物分子检测的新型电动生物传感器来解决现有的挑战。

1351253 - GagnonThe overall goal of this Faculty Early Career Development (CAREER) Program grant is to develop inexpensive and portable biosensors for rapid, sensitive and specific label-free multiplexed biomolecular detection. The possibility of miniaturizing biosensing systems which use miniscule quantities of expensive reagents and precious samples, provide faster analyses to patients and doctors, and do not require a trained technician to operate has immediate applications in preventing disease in developing countries, biowarfare/anti-terrorism applications, environmental monitoring, point-of-care diagnostic testing and for basic biological research.A major obstacle towards accomplishing this goal is the lack of an available biosensor that is rapid, sensitive and specific to small concentrations of target biomolecules, yet does not require the labeling of probes or optical microscopy, and can operate without the need for complex and bulky supporting instrumentation. This project will address existing challenges by focusing on the development of novel electrokinetic biosensors for biomolecular detection at liquid interfaces.