The effect of testosterone pulses and conditioned place preferences on social behavior in wild and laboratory Peromyscus mice

睾酮脉冲和条件性位置偏好对野生和实验室白鼠社交行为的影响

• 批准号: 1355163
• 负责人: Catherine Marler
• 金额: $ 78万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1355163&HistoricalAwards=false
• 关键词: effect; testosterone; pulses; conditioned; place

When an individual animal interacts with another individual, it has a physiological response. The researchers are trying to understand how physiological responses can influence current and future behavior. Other studies have shown that hormones, such as testosterone, can increase after a social interaction. An important question is whether this hormone release can influence future behavior. Because some hormones can result in a positive, rewarding response, a preference for a location can form in response to the release of a hormone such as testosterone. Thus, any male-male or male-female interaction that results in the release of testosterone may induce an individual to seek out that location repeatedly. Hormone release may therefore influence how individuals use space through the development of preferences for specific locations. This research investigates, for the first time, the natural function of the reward-like properties of testosterone related to the development of preferences for specific locations. This research may reveal a new mechanism, testosterone pulses, for responding rapidly to adapt to changing social conditions associated with specific locations.The researchers use conditioned place preference development in response to testosterone injections to provide insight into the mechanisms balancing the different social demands of a monogamous and territorial species, the biparental California mouse. The hypothesis is that testosterone pulses induce spatial distributions appropriate for the social demands of the environment and, in turn, alter context appropriate behaviors in the form of paternal and territorial behavior, pair bond maintenance, mate advertisement and mate-attendance. The testosterone-induced spatial distribution may influence behavior only through location or may further amplify and alter social interactions. Within this framework, the researchers test questions in both simple and complex environments. They examine complex aspects of testosterone-modified social interactions by assessing acoustic communication in the field and laboratory. The researchers propose to examine three aims to address the function of T pulses and resulting effects on conditioned place preferences and social behavior for focal pair-bonded males and their mates (Aim 1a), focal male interactions with pups (Aim 1b), focal male interactions with a female intruder (Aim 2), and focal male interactions with a male intruder (Aim 3). This research will create a stimulating and collaborative student-training environment with unique experiences that integrate behavioral endocrinology studies in the field and laboratory. The collaboration between a midwestern R1 and small southern research institution with fieldwork conducted at the Hastings Natural History Reserve in California, will facilitate wide dissemination of expertise across researchers and students, including STEM URM students. The project will be integrated with a successful 10-year old outreach program called "Bats and Mice in Your Backyard." Two software packages are being developed to automate the analysis of ultrasonic vocalizations and mouse behavior from thermal videos collected in the field and will be made available under an open source license

当一个动物个体与另一个个体相互作用时，它会产生生理反应。 研究人员试图了解生理反应如何影响当前和未来的行为。其他研究表明，激素，如睾丸激素，可以在社会交往后增加。一个重要的问题是这种激素的释放是否会影响未来的行为。因为一些激素可以导致积极的，有益的反应，对一个位置的偏好可以形成对激素（如睾丸激素）释放的反应。因此，任何导致睾酮释放的男性-男性或男性-女性相互作用都可能诱导个体反复寻找该位置。因此，荷尔蒙的释放可能会通过发展对特定位置的偏好来影响个人如何使用空间。这项研究首次调查了睾酮的奖励性质的自然功能，这些性质与特定位置偏好的发展有关。 这项研究可能揭示了一种新的机制，睾丸激素脉冲，用于快速响应以适应与特定位置相关的不断变化的社会条件。研究人员使用条件性位置偏好发展来响应睾丸激素注射，以深入了解一夫一妻制和领土物种，即双亲加州小鼠的不同社会需求之间的平衡机制。该假说是，睾酮脉冲诱导空间分布适合的社会需求的环境，反过来，改变上下文适当的行为的形式，父亲和领土的行为，对债券的维护，配偶广告和配偶出席。睾丸激素诱导的空间分布可能只通过位置影响行为，或者可能进一步放大和改变社会互动。在这个框架内，研究人员在简单和复杂的环境中测试问题。他们通过评估现场和实验室中的声学通信来研究睾丸激素修饰的社会互动的复杂方面。研究人员建议检查三个目标，以解决T脉冲的功能及其对条件性位置偏好和社会行为的影响，用于焦点配对结合男性及其配偶（Aim 1a），焦点男性与幼崽的互动（Aim 1b），焦点男性与女性入侵者的互动（Aim 2），以及焦点男性与男性入侵者的互动（Aim 3）。这项研究将创造一个激励和协作的学生培训环境，具有独特的经验，整合了现场和实验室的行为内分泌学研究。中西部R1和小型南方研究机构之间的合作，在加州的黑斯廷斯自然历史保护区进行实地考察，将促进研究人员和学生（包括STEM URM学生）的专业知识的广泛传播。该项目将与一个成功的10岁的推广计划，称为“蝙蝠和老鼠在你的后院。“正在开发两个软件包，用于自动分析现场收集的热视频中的超声波发声和鼠标行为，并将在开源许可证下提供

项目成果

Testosterone-related behavioral and neural mechanisms associated with location preferences: A model for territorial establishment

• DOI: 10.1016/j.yhbeh.2020.104709
• 发表时间: 2020-05-01
• 期刊: HORMONES AND BEHAVIOR
• 影响因子: 3.5
• 作者: Zhao，Xin;Castelli，Frank R.;Marler，Catherine A.
• 通讯作者: Marler，Catherine A.