Cross-Generational Transmission of Aggression: Behavioral, Hormonal and Neural Mechanisms

攻击性的跨代传递：行为、激素和神经机制

• 批准号: 0620042
• 负责人: Catherine Marler
• 金额: $ 30.4万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0620042&HistoricalAwards=false
• 关键词: Cross; Generational; Transmission; Aggression; Behavioral

The goal of this project is to investigate the behavioral and neuroendocrine mechanisms that propagate aggression across generations through epigenetic mechanisms in a highly paternal and aggressive mouse. Fathers may be particularly important for impacting aggression of offspring during development and perhaps more so than mothers. This process occurs through paternal behaviors such as retrieval of pups, which increases aggression levels of adult offspring. Furthermore the father's behavior causes long term changes in the distribution of the neuropeptide vasopressin in the nervous system that may influence both aggressive and paternal behaviors. A series of behavioral, physiological and neural mechanisms will be tested for involvement in the propagation of aggression and paternal behavior across generations. Hormones such as testosterone and progesterone are likely to be involved in responsiveness to the social environment and are likely to interact with the network of brain areas involved in aggressive and parental behaviors. This research will help us to understand some of the basic mechanisms that are involved in propagating social behaviors across generations at both a behavioral and cellular level. Overall, there is a dearth of knowledge about the behavioral and biological mechanisms through which parental behavior exerts long-term, non-genetic influences on the development of offspring behavior. Furthermore, in both human and animal studies, the effects of paternal behavior on offspring have received much less attention than maternal behavior. The proposed research offers an opportunity to receive broad training experience for students bridging animal behavior and behavioral endocrinology. This project will offer undergraduate and graduate students unique research opportunities, and will promote training of underrepresented minorities.

该项目的目标是研究行为和神经内分泌机制，通过表观遗传机制在高度父系和攻击性小鼠中传播跨代攻击性。父亲可能是特别重要的影响侵略的后代在发展过程中，也许比母亲。这一过程通过父系行为发生，如取回幼崽，这增加了成年后代的攻击水平。此外，父亲的行为会导致神经系统中神经肽血管加压素分布的长期变化，这可能会影响攻击行为和父亲行为。一系列的行为，生理和神经机制将被测试参与跨代传播的侵略和父亲的行为。像睾丸激素和孕酮这样的激素可能参与对社会环境的反应，并且可能与涉及攻击性和父母行为的大脑区域网络相互作用。这项研究将帮助我们了解在行为和细胞水平上跨代传播社会行为的一些基本机制。总的来说，关于父母行为对后代行为发展产生长期、非遗传影响的行为和生物学机制的知识还很缺乏。此外，在人类和动物研究中，父亲行为对后代的影响比母亲行为受到的关注要少得多。拟议的研究提供了一个机会，以获得广泛的培训经验，为学生桥接动物行为和行为内分泌学。 该项目将为本科生和研究生提供独特的研究机会，并将促进对代表性不足的少数民族的培训。