I-Corps: Biomimetic Degradable Load Bearing Osteoconductive Bone Graft

I-Corps：仿生可降解承重骨传导骨移植物

• 批准号: 1357109
• 负责人: Esmaiel Jabbari
• 金额: $ 5万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1357109&HistoricalAwards=false
• 关键词: Corps; Biomimetic; Degradable; Load; Bearing

The technology developed through this project generates a bone implant that maintains its shape and provides mechanical stability to allow bone to form around the implant. Afterward, the implant degrades with time to provide volume for new bone formation. This combines the microstructure of cortical bone with degradability of polyester nanofibers to address the issues of scaffold resorption, strength and uniform nutrient supply. To address the issues of compressive strength and resorption, the team will engineer calcium phosphate (CaP) deposited polyester nanofiber sheets with high CaP content. To address the issue of uniform nutrient supply, the team will engineer a bonded set of macroporous laminated microtubes with interconnected canals. Upon seeding the scaffold with progenitor cells, a pre-vascularized resorbable and stiff graft is formed for implantation in a bone defect.Unlike metallic implants that are non-resorbable and shield stress or ceramic and plastic implants that are brittle and deformable, the product of this invention mimics the structure of natural cortical bone for mechanical stability, degradation, and uniform nutrient supply. Competitive advantages include tunable resorption, load bearing with tunable mechanical strength, osteoconductive to support new bone formation, interconnected microtubular structure for uniform nutrient transport, and compatible with growth factors and stem cells. Application o fthis technology can migrate to areas other than orthopedics, like in pharmaceutics for drug delivery and targeting, in bioprinting for generation of complex structures and 3D models of human tissues, and engineering multifunctional biosensors.

通过该项目开发的技术生成的骨植入物可以保持其形状并提供机械稳定性，以允许骨骼在植入物周围形成。之后，植入物随着时间的推移而降解，为新骨形成提供体积。它将皮质骨的微观结构与聚酯纳米纤维的可降解性相结合，以解决支架吸收、强度和均匀营养供应的问题。为了解决抗压强度和吸收问题，该团队将设计具有高 CaP 含量的磷酸钙 (CaP) 沉积聚酯纳米纤维片。为了解决均匀营养供应的问题，该团队将设计一组具有互连管道的粘合大孔层压微管。在用祖细胞接种支架后，形成预血管化的可再吸收且坚硬的移植物，用于植入骨缺损中。与不可再吸收并屏蔽应力的金属植入物或易碎且可变形的陶瓷和塑料植入物不同，本发明的产品模仿天然皮质骨的结构，以实现机械稳定性、降解和均匀的营养供应。竞争优势包括可调节的吸收、具有可调节机械强度的承载、支持新骨形成的骨传导性、用于均匀营养输送的互连微管结构以及与生长因子和干细胞相容。该技术的应用可以扩展到骨科以外的领域，例如用于药物输送和靶向的药剂学、用于生成人体组织的复杂结构和 3D 模型的生物打印以及工程多功能生物传感器。