MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase Contrast

MRI：获取具有亚微米分辨率、可调视场和相衬的双能 3D X 射线显微镜

• 批准号: 1429068
• 负责人: Elise Morgan
• 金额: $ 42万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-10-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1429068&HistoricalAwards=false
• 关键词: MRI; Acquisition; Dual; Energy; Ray

PI: Morgan, Elise F.Proposal: 1429068Title: MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase ContrastSignificance3-D X-ray microscopy (XRM) has recently emerged as a non-destructive imaging modality with unprecedented versatility for study of numerous types of materials and structures. Newly developed XRM systems overcome key limitations of older systems, including the rigid trade-off between specimen size and image resolution (fixed field of view), inability to consolidate image data obtained from multiple beam energies, and reliance on absorption contrast as the only mode of imaging. As a result, XRM is now viable for a host of new and diverse applications in engineering and natural sciences. The XRM instrument for which funds are requested in this proposal is extremely well suited for fostering the integration of research and education. This instrument generates rich data sets via user-friendly software and hardware interfaces. These data, which include high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures, are amenable to research projects and class assignments for students at multiple levels.Technical DescriptionThe research activities that will use this instrumentation address fundamental physical and biological phenomena in biomechanics, tissue engineering, skeletal and evolutionary biology, microfluidics, earth science, complex fluids, and high-temperature materials. Currently, these research activities use multiple methods, most of which are 2-D and/or destructive, to quantify microstructure and composition. The requested XRM instrument would add a new and profoundly enabling dimension to this existing armamentarium. This instrument generates rich data sets via user-friendly software and hardware interfaces. The data includes high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures.

主要研究者：Morgan，Elise F.提案：1429068标题：核磁共振成像：具有亚微米分辨率、可调视场和相位对比度的双能三维X射线显微镜的获得意义三维X射线显微镜（XRM）最近已成为一种非破坏性成像模式，具有前所未有的多功能性，可用于研究多种类型的材料和结构。新开发的XRM系统克服了旧系统的关键限制，包括标本大小和图像分辨率（固定视场）之间的刚性权衡，无法合并从多个光束能量获得的图像数据，以及依赖于吸收对比度作为唯一的成像模式。因此，XRM现在适用于工程和自然科学中的许多新的和多样化的应用。 本提案中要求提供资金的XRM工具非常适合促进研究与教育的结合。该仪器通过用户友好的软件和硬件接口生成丰富的数据集。这些数据，其中包括高分辨率的3-D效果图，横截面视图，和定量结构措施，是服从于研究项目和课堂作业的学生在多个层次。技术说明研究活动，将使用这种仪器地址的基本物理和生物现象，在生物力学，组织工程，骨骼和进化生物学，微流体，地球科学，复杂流体，和高温材料。目前，这些研究活动使用多种方法，其中大多数是2-D和/或破坏性的，以量化微观结构和组成。所要求的XRM工具将为这一现有设备增加一个新的和深刻的使能层面。该仪器通过用户友好的软件和硬件接口生成丰富的数据集。这些数据包括高分辨率的三维渲染图、横截面视图和定量结构测量。