MRI: Acquisition of a Leica TCS SPE confocal microscope for a shared facility to advance undergraduate research and teaching in the W.M. Keck Science Department

MRI：为共享设施购买 Leica TCS SPE 共焦显微镜，以推进 W.M. 的本科生研究和教学。

• 批准号: 1429350
• 负责人: Jennifer Armstrong
• 金额: $ 23.35万
• 依托单位: Claremont McKenna College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1429350&HistoricalAwards=false
• 关键词: MRI; Acquisition; Leica; TCS; SPE

An award is made to the W. M. Keck Science Department (Keck Science) of Claremont McKenna College, Pitzer College, and Scripps College to acquire a Leica TCS SPE scanning confocal microscope. Keck Science serves students from three distinct, highly selective liberal arts colleges. A primary departmental goal is to offer a modern education in the sciences through hands-on, investigative, and hypothesis-driven learning. The new confocal capabilities will allow Keck Science faculty to modernize three existing advanced biology courses through specific learning outcomes involving fluorescence analysis of whole tissues, while incorporating current, investigative research projects. This confocal microscope will enhance the research program of numerous Keck Science faculty and their undergraduate students who are investigating a wide range of important topics across the sciences. In addition, it will facilitate exciting science outreach activities with the Scripps College Academy, an academic program developed to serve the needs of female students in Southern California from high schools in underserved areas. The Leica TCS SPE confocal microscope will substantially enhance the Keck Science research program by elevating current limits of conventional microscopic analysis to achieve high-resolution, fluorescence imaging of thick, intact tissues in 3-D, as well as real-time imaging of cellular processes in live tissues. The new confocal capabilities will dramatically improve ongoing research projects of undergraduate research students and their faculty mentors in Keck Science and nearby institutions in the fields of cell biology, genetics, neurobiology and evolution. These projects include fluorescence analyses of chromatin dynamics; effects of selfish genetic elements in insect tissues; investigations of neuronal structure and function in the avian model system, the zebra finch; and phylogenetically guided analyses of the fine structure and function of the teleost retina.

克莱蒙特麦肯纳学院、皮策学院和斯克里普斯学院的w·m·凯克科学系获得了一台徕卡TCS SPE扫描共聚焦显微镜。凯克科学服务于三所不同的，高度选择性的文理学院的学生。一个主要部门的目标是通过实践，调查和假设驱动的学习提供科学的现代教育。新的共聚焦能力将使凯克科学学院通过具体的学习成果，包括整个组织的荧光分析，同时结合当前的调查研究项目，使现有的三门高级生物学课程现代化。这种共聚焦显微镜将加强许多凯克科学学院和他们的本科生的研究计划，他们正在调查科学领域广泛的重要课题。此外，它还将促进与斯克里普斯学院（Scripps College Academy）开展的令人兴奋的科学推广活动。斯克里普斯学院是一个学术项目，旨在满足南加州服务不足地区高中女学生的需求。徕卡TCS SPE共聚焦显微镜将极大地增强凯克科学研究计划，通过提高传统显微镜分析的当前限制，实现厚的、完整组织的三维高分辨率荧光成像，以及活组织中细胞过程的实时成像。新的共聚焦能力将极大地改善凯克科学和附近机构的本科研究生及其教师导师在细胞生物学、遗传学、神经生物学和进化领域的研究项目。这些项目包括染色质动力学的荧光分析；自私遗传因子在昆虫组织中的作用鸟类模型系统斑胸草雀神经元结构与功能的研究以及硬骨鱼视网膜精细结构和功能的系统发育指导分析。