MRI: Acquisition of a Leica M205 FA Stereomicroscope with Fluorescence

授予位于奥斯韦戈的纽约州立大学购买一台带荧光的Leica M205 FA立体显微镜，以便于分析，并提供培养中固定和活的整体生物体、组织或器官的高质量明场或荧光图像。这种显微镜不仅可以让研究人员在他们的个人研究项目以及与化学和人类学系的教师合作方面取得重大进展，而且还可以扩大与当地高中教师及其学生的互动。作为NCATE认证的机构，SUNY奥斯韦戈为高级安置（AP）生物学教师和进入2-10年级的学生提供课程和培训计划，使SUNY奥斯韦戈的教师和当地科学教师和学生社区之间的直接联系和沟通。调查人员特别致力于促进当地学校学生的培训和参与，这些学校位于纽约州一个社会经济困难的地区。Leica M205 FA荧光体视显微镜通过加强研究、研究培训、教学和社区外展，极大地支持了纽约州立大学奥斯韦戈的项目。该仪器将立即促进以下生物过程的研究：各种信号通路之间的相互作用，以了解独特体型的形成;导致线虫C染色体进化的遗传因素。优雅;淡水贻贝中水生螨的致病性，这将有助于保护这些生态系统健康的生物指标;定向细胞迁移，这对于了解生理和病理生理至关重要。完整生物体和组织的显微镜检查，加上荧光标记物的进步，可以通过遗传编码来过度表达或敲除基因信号传导途径，是生物结构，发育和功能基础研究的有力工具。提高整体或器官成像技术的空间和时间分辨率对于实现这种方法的全部潜力至关重要。配备荧光系统的Leica M205 FA立体显微镜将被安置在SUNY奥斯韦戈的分子生物学生物化学中心（MBBC），确保显微镜的可用性以培训新用户，并由于MBBC设施靠近教师而便于仪器的维护。

An award is made to State University of New York at Oswego to purchase a Leica M205 FA Stereomicroscope with fluorescence to facilitate analyses and to provide high quality bright field or fluorescence images of fixed and living whole-mount organisms, tissues, or organs in culture. This microscope will not only allow investigators to make significant progress with their individual research projects and collaborations with faculty of the chemistry and anthropology departments, but will have broader impacts with regards to expanding interactions with local high school teachers and their students. Being a NCATE-accredited institution, SUNY Oswego offers courses and training program to teachers of advanced placement (AP) biology and to students entering grades 2-10, enabling direct connections and communication between the faculty of SUNY Oswego and the local science teacher and student community. The investigators are particularly committed to promoting training and participation of students from local schools, which are in a socioeconomically challenged region of New York State. The Leica M205 FA Stereomicroscope with fluorescence significantly bolsters programs at SUNY Oswego by enhancing research, research training, teaching, and community outreach. The instrument will immediately facilitate the study of the following biological processes: interactions between various signaling pathways to learn about formation of unique body forms; genetic factors leading to the evolution of chromosomes in the nematode C. Elegans; pathogenicity of aquatic mites in freshwater mussels, which will aid in conserving these biological indicators of ecosystem health; directed cell migration, which is essential for understanding physiological and pathophysiological. Microscopy of intact organisms and tissues, coupled with the advance of fluorescent markers that can be genetically encoded to overexpress or knock down gene signaling pathways, is a powerful tool for basic research into biological structure, development, and function. Improving spatial and temporal resolution of whole-mount or organ imaging techniques is essential to realize the full potential of this approach. The Leica M205 FA Stereomicroscope with fluorescence system will be housed in the Molecular Biology & Biochemistry Center (MBBC) at SUNY Oswego, ensuring the availability of the microscope to train new users, and facilitating maintenance of the instrument due to the proximity of the MBBC facility to faculty.