MRI: Acquisition of a Leica M205 FA Stereomicroscope with Fluorescence

美国纽约州立大学奥斯威戈分校获得了购买一台徕卡M205 FA荧光立体显微镜的奖励，以方便分析，并提供高质量的亮场或荧光图像，用于固定和活的全挂装生物、组织或培养器官。这台显微镜不仅能让研究人员在他们的个人研究项目和与化学系和人类学系的合作中取得重大进展，而且还能在扩大与当地高中教师和学生的互动方面产生更广泛的影响。作为ncate认证的机构，纽约州立大学奥斯威戈分校为AP生物教师和2-10年级的学生提供课程和培训计划，使纽约州立大学奥斯威戈分校的教师与当地科学教师和学生社区之间建立直接联系和交流。调查人员特别致力于促进当地学校学生的培训和参与，这些学校位于纽约州社会经济困难的地区。徕卡M205 FA荧光立体显微镜通过加强研究、研究培训、教学和社区外展，显著支持了纽约州立大学奥斯威戈分校的项目。该仪器将立即促进以下生物过程的研究：各种信号通路之间的相互作用，以了解独特形体的形成；线虫染色体进化的遗传因素；淡水贻贝中水螨的致病性，有助于保护这些生态系统健康的生物指标；定向细胞迁移，这是必不可少的理解生理和病理生理。对完整的生物体和组织进行显微镜观察，再加上荧光标记的进步，这些荧光标记可以通过基因编码来过表达或敲低基因信号通路，是生物结构、发育和功能基础研究的有力工具。提高全挂载或器官成像技术的空间和时间分辨率是实现这种方法的全部潜力的必要条件。带有荧光系统的徕卡M205 FA立体显微镜将被安置在纽约州立大学奥斯威戈分校的分子生物学和生物化学中心（MBBC），以确保显微镜的可用性，以培训新用户，并方便仪器的维护，因为MBBC设施离教师很近。

An award is made to State University of New York at Oswego to purchase a Leica M205 FA Stereomicroscope with fluorescence to facilitate analyses and to provide high quality bright field or fluorescence images of fixed and living whole-mount organisms, tissues, or organs in culture. This microscope will not only allow investigators to make significant progress with their individual research projects and collaborations with faculty of the chemistry and anthropology departments, but will have broader impacts with regards to expanding interactions with local high school teachers and their students. Being a NCATE-accredited institution, SUNY Oswego offers courses and training program to teachers of advanced placement (AP) biology and to students entering grades 2-10, enabling direct connections and communication between the faculty of SUNY Oswego and the local science teacher and student community. The investigators are particularly committed to promoting training and participation of students from local schools, which are in a socioeconomically challenged region of New York State. The Leica M205 FA Stereomicroscope with fluorescence significantly bolsters programs at SUNY Oswego by enhancing research, research training, teaching, and community outreach. The instrument will immediately facilitate the study of the following biological processes: interactions between various signaling pathways to learn about formation of unique body forms; genetic factors leading to the evolution of chromosomes in the nematode C. Elegans; pathogenicity of aquatic mites in freshwater mussels, which will aid in conserving these biological indicators of ecosystem health; directed cell migration, which is essential for understanding physiological and pathophysiological. Microscopy of intact organisms and tissues, coupled with the advance of fluorescent markers that can be genetically encoded to overexpress or knock down gene signaling pathways, is a powerful tool for basic research into biological structure, development, and function. Improving spatial and temporal resolution of whole-mount or organ imaging techniques is essential to realize the full potential of this approach. The Leica M205 FA Stereomicroscope with fluorescence system will be housed in the Molecular Biology & Biochemistry Center (MBBC) at SUNY Oswego, ensuring the availability of the microscope to train new users, and facilitating maintenance of the instrument due to the proximity of the MBBC facility to faculty.