GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven Flows

GOALI：通过磁力驱动流将血栓溶解药物对流输送至中风患者的死端动脉

• 批准号: 1437354
• 负责人: Roger Bonnecaze
• 金额: $ 26.12万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1437354&HistoricalAwards=false
• 关键词: GOALI; Convective; Delivery; Clot; Busting

CBET 1437354Bonnecaze, Roger T.GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven FlowsWhen flow through a liquid-filled tube is blocked because of an obstruction, it is difficult to deliver chemical agents that could remove the obstruction and restore flow through the channel. Partial or complete obstruction of flow can occur in a variety of situations, perhaps most notably in stroke victims whose cerebral blood flow is blocked owing to a blood clot in a vessel. Delivering drugs such as tissue plasminogen activator (tPA) that can dissolve a clot and restore blood flow is a challenge because the drug must diffuse to the clot, which is slow and often ineffective. This GOALI project will explore the use of micron-sized iron particles in a magnetic field that can cause fluid mixing in blocked channels and improve transport of tPA along the length of the vessel to the clot. Investigators at The University of Texas and Pulse Therapeutics, Inc. will conduct a series of experiments and numerical simulations to analyze the flow induced by the particles and optimize transport of clot-dissolving agents in blocked vessels. The results of the project could improve the effectiveness of tPA therapy, and be helpful in a diverse array of technological applications, including using surfactants to remove trapped water in shale and tight gas-sand reservoirs to improve oil and gas production.This GOALI project will develop an experimentally validated model and simulation of magnetically driven convection of iron-containing fluid to understand how the strength of the magnetic field, its gradient and rotation rate generate flow and the sensitivities of the flow to these parameters. The simulation tool will help optimize design of the magnetic system and selection of particle properties. At the particle scale conservation equations will describe the local concentration of free particles and particles that chain together to form rods, including the formation and destruction of the rods due to the applied magnetic field, shear flow and interactions with the walls of the vessels. It is hypothesized that these rods rotate in the field and generate localized vorticity that drives the macroscopic convective flow in the vessel. At the vessel scale conservation of mass and momentum equations will describe this magnetically-induced vorticity driven flow. The model equations will be solved asymptotically and numerically to understand this unique process for creating convective flows in dead-end or blocked vessels. Complementary experiments conducted by research team at Pulse Therapeutics will validate the model and indicate modifications as necessary.

CBET 1437354 Bonnecaze，Roger T.GOALI：通过磁驱动流将血栓破坏药物对流输送到中风患者的死端动脉当通过充满液体的管道的流动由于阻塞而被阻塞时，很难输送可以去除阻塞并恢复通过通道的流动的化学试剂。 血流的部分或完全阻塞可能发生在各种情况下，可能最明显的是中风患者，其脑血流由于血管中的血块而被阻塞。 递送诸如组织纤溶酶原激活剂（tPA）之类的可以溶解凝块并恢复血流的药物是一项挑战，因为药物必须扩散到凝块，这是缓慢的并且通常无效的。 该GOALI项目将探索在磁场中使用微米大小的铁颗粒，其可以在阻塞的通道中引起流体混合，并改善tPA沿着血管长度向凝块的运输。德克萨斯大学和Pulse Therapeutics，Inc.的研究人员将进行一系列的实验和数值模拟，以分析由颗粒引起的流动，并优化血栓溶解剂在堵塞血管中的输送。 该项目的结果可以提高tPA疗法的有效性，并有助于各种技术应用，包括使用表面活性剂去除页岩和致密气砂储层中的截留水，以提高石油和天然气产量。该GOALI项目将开发一个实验验证的模型和模拟含铁流体的磁驱动对流，以了解磁场的强度，其梯度和旋转速率产生流动以及流动对这些参数的敏感性。 该仿真工具将有助于优化磁系统的设计和颗粒特性的选择。 在颗粒尺度上，守恒方程将描述自由颗粒和链在一起形成棒的颗粒的局部浓度，包括由于施加的磁场、剪切流和与容器壁的相互作用而导致的棒的形成和破坏。 假设这些杆在场中旋转并产生局部涡度，该涡度驱动血管中的宏观对流。在船舶尺度上，质量和动量守恒方程将描述这种磁致涡量驱动的流动。模型方程将渐近和数值求解，以了解在死端或堵塞的血管中产生对流的独特过程。Pulse Therapeutics的研究团队进行的补充实验将验证模型，并在必要时指出修改。