GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven Flows

CBET 1437354 Bonnecaze，Roger T.GOALI：通过磁力驱动流动向中风患者的死端动脉对流输送破块药物当通过充满液体的管子的流动因阻塞而受阻时，很难输送能够消除阻塞并恢复通过该通道的流动的化学制剂。血流的部分或完全阻塞可能发生在各种情况下，可能最明显的是中风患者，他们的大脑血流因血管中的血块而受阻。输送组织纤溶酶原激活剂(TPA)等可以溶解血栓并恢复血液流动的药物是一个挑战，因为药物必须扩散到血栓中，这是缓慢的，而且往往无效。这个GALI项目将探索在磁场中使用微米级的铁颗粒，这种颗粒可以在堵塞的通道中引起流体混合，并改善tPA沿血管长度到凝块的传输。德克萨斯大学和Pulse Treateutics，Inc.的研究人员将进行一系列实验和数值模拟，以分析颗粒诱导的流动，并优化血栓溶解剂在堵塞的血管中的传输。该项目的结果可以提高tPA治疗的有效性，并有助于一系列不同的技术应用，包括使用表面活性剂去除页岩和致密气砂储层中的滞留水，以提高石油和天然气产量。该项目将开发一个经过实验验证的含铁流体磁驱动对流模型和模拟，以了解磁场的强度、梯度和旋转速度如何产生流动，以及流动对这些参数的敏感性。该模拟工具将有助于优化磁系统的设计和粒子特性的选择。在粒子尺度上，守恒方程将描述自由粒子和链接在一起形成棒的粒子的局部浓度，包括由于外加磁场、剪切流和与血管壁的相互作用而形成和破坏棒的过程。假设这些棒在场中旋转，并产生局域涡量，从而驱动容器内的宏观对流。在容器尺度上，质量守恒方程和动量守恒方程将描述这种由磁致涡量驱动的流动。模型方程将被渐近和数值求解，以了解在死端或堵塞的容器中产生对流的这一独特过程。脉冲治疗公司的研究团队进行的补充实验将验证该模型，并根据需要进行修改。

CBET 1437354Bonnecaze, Roger T.GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven FlowsWhen flow through a liquid-filled tube is blocked because of an obstruction, it is difficult to deliver chemical agents that could remove the obstruction and restore flow through the channel. Partial or complete obstruction of flow can occur in a variety of situations, perhaps most notably in stroke victims whose cerebral blood flow is blocked owing to a blood clot in a vessel. Delivering drugs such as tissue plasminogen activator (tPA) that can dissolve a clot and restore blood flow is a challenge because the drug must diffuse to the clot, which is slow and often ineffective. This GOALI project will explore the use of micron-sized iron particles in a magnetic field that can cause fluid mixing in blocked channels and improve transport of tPA along the length of the vessel to the clot. Investigators at The University of Texas and Pulse Therapeutics, Inc. will conduct a series of experiments and numerical simulations to analyze the flow induced by the particles and optimize transport of clot-dissolving agents in blocked vessels. The results of the project could improve the effectiveness of tPA therapy, and be helpful in a diverse array of technological applications, including using surfactants to remove trapped water in shale and tight gas-sand reservoirs to improve oil and gas production.This GOALI project will develop an experimentally validated model and simulation of magnetically driven convection of iron-containing fluid to understand how the strength of the magnetic field, its gradient and rotation rate generate flow and the sensitivities of the flow to these parameters. The simulation tool will help optimize design of the magnetic system and selection of particle properties. At the particle scale conservation equations will describe the local concentration of free particles and particles that chain together to form rods, including the formation and destruction of the rods due to the applied magnetic field, shear flow and interactions with the walls of the vessels. It is hypothesized that these rods rotate in the field and generate localized vorticity that drives the macroscopic convective flow in the vessel. At the vessel scale conservation of mass and momentum equations will describe this magnetically-induced vorticity driven flow. The model equations will be solved asymptotically and numerically to understand this unique process for creating convective flows in dead-end or blocked vessels. Complementary experiments conducted by research team at Pulse Therapeutics will validate the model and indicate modifications as necessary.