GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven Flows

GOALI：通过磁力驱动流将血栓溶解药物对流输送至中风患者的死端动脉

• 批准号: 1437354
• 负责人: Roger Bonnecaze
• 金额: $ 26.12万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1437354&HistoricalAwards=false
• 关键词: GOALI; Convective; Delivery; Clot; Busting

CBET 1437354Bonnecaze, Roger T.GOALI: Convective Delivery of Clot-Busting Drugs to Dead-End Arteries for Stroke Victims by Magnetically Driven FlowsWhen flow through a liquid-filled tube is blocked because of an obstruction, it is difficult to deliver chemical agents that could remove the obstruction and restore flow through the channel. Partial or complete obstruction of flow can occur in a variety of situations, perhaps most notably in stroke victims whose cerebral blood flow is blocked owing to a blood clot in a vessel. Delivering drugs such as tissue plasminogen activator (tPA) that can dissolve a clot and restore blood flow is a challenge because the drug must diffuse to the clot, which is slow and often ineffective. This GOALI project will explore the use of micron-sized iron particles in a magnetic field that can cause fluid mixing in blocked channels and improve transport of tPA along the length of the vessel to the clot. Investigators at The University of Texas and Pulse Therapeutics, Inc. will conduct a series of experiments and numerical simulations to analyze the flow induced by the particles and optimize transport of clot-dissolving agents in blocked vessels. The results of the project could improve the effectiveness of tPA therapy, and be helpful in a diverse array of technological applications, including using surfactants to remove trapped water in shale and tight gas-sand reservoirs to improve oil and gas production.This GOALI project will develop an experimentally validated model and simulation of magnetically driven convection of iron-containing fluid to understand how the strength of the magnetic field, its gradient and rotation rate generate flow and the sensitivities of the flow to these parameters. The simulation tool will help optimize design of the magnetic system and selection of particle properties. At the particle scale conservation equations will describe the local concentration of free particles and particles that chain together to form rods, including the formation and destruction of the rods due to the applied magnetic field, shear flow and interactions with the walls of the vessels. It is hypothesized that these rods rotate in the field and generate localized vorticity that drives the macroscopic convective flow in the vessel. At the vessel scale conservation of mass and momentum equations will describe this magnetically-induced vorticity driven flow. The model equations will be solved asymptotically and numerically to understand this unique process for creating convective flows in dead-end or blocked vessels. Complementary experiments conducted by research team at Pulse Therapeutics will validate the model and indicate modifications as necessary.

CBET 1437354BONNECAIZE，ROGER T.GOALI：通过磁性驱动的流通过液体填充管的流动被阻塞，将凝块破坏药物的对流输送到死端的动脉中，由于阻塞而被阻塞，由于阻塞，很难消除阻塞和恢复通过通道的障碍物。 在各种情况下可能会发生部分或完全的流动障碍，也许最著名的是，由于血管中的血块，其脑血流被阻塞的中风受害者。 输送可以溶解血块并恢复血液的组织纤溶酶原激活剂（TPA）等药物是一个挑战，因为该药物必须扩散到凝块，这是缓慢且通常无效的凝块。 该守门员项目将探索在磁场中使用微米大小的铁颗粒的使用，该磁场可能会在阻塞通道中引起流体混合并改善TPA沿血管长度到凝块的运输。德克萨斯大学和Pulse Therapeutics，Inc。的研究人员将进行一系列实验和数值模拟，以分析由颗粒诱导的流量并优化阻塞容器中凝块溶解剂的运输。 该项目的结果可以提高TPA治疗的有效性，并有助于多样化的技术应用，包括使用表面活性剂去除在页岩和紧密的天然气和气体中取水以改善石油和天然气的生产。该守门员将开发经过实验性验证的验证模型和对铁的磁场的磁性和旋转的磁性范围，以使磁性的速度和旋转的速度旋转，并具有磁性的速度，使得磁性旋转的速度和旋转的速度，使得有效地有效地旋转，使得有效地旋转，使得有效地有效，可以实现良好的能力，并具有磁性的范围，该速度又有能力且能够实现的磁性范围。流向这些参数的敏感性。 模拟工具将有助于优化磁系统的设计和粒子特性的选择。 在粒子尺度上，保护方程将描述链条链的局部浓度，这些颗粒和颗粒将链条链在一起形成杆，包括由于施加的磁场，剪切流以及与容器壁相互作用而导致的杆的形成和破坏。 假设这些杆在田间旋转并产生局部涡度，从而驱动容器中的宏观对流流动。在容器尺度上，质量和动量方程将描述这种磁诱导的涡度驱动流动。该模型方程将渐近地和数值求解，以了解这种独特的过程，以在死胡同或阻塞容器中产生对流流。研究小组在脉冲治疗学上进行的互补实验将验证模型并在必要时指示修改。