Meeting: Keystone Symposia on "Plant Receptor Kinases" to be held in Taos, NM from February 8-13, 2015

植物在不断变化的环境和发育条件下快速准确地做出反应，必须迅速将细胞外信号转化为适当的细胞内反应。细胞表面受体激酶（RKs）是这种细胞外感知的主要成分之一。与动物相比，植物显示出RK家族的巨大扩张。然而，只有非常有限数量的植物RKs具有指定的功能，但那些具有特征的RKs控制着从发育到对生物和非生物胁迫的反应等关键方面。2015年“植物受体激酶：从分子到环境”专题讨论会将重点介绍我们对RKs的理解的最新进展，从它们的进化和它们所参与的途径，到它们功能背后的分子细节，从而为讨论新兴主题提供平台。植物RKs控制的过程包括气体交换、先天免疫、有益共生关系的建立和内在生长/产量的控制。因此，在田间和生态系统层面上，对植物的表现有许多直接的影响，这次会议将引起学术界、政府和私营部门科学家的广泛兴趣。在这次会议上提出的主题的多样性通常不会在一次会议中涵盖。其他会议，根据需要，专注于特定领域，而这次Keystone专题会议将汇集各自领域的世界领导人，通过分享最新的研究成果和新的实验方法/方法，也将促进其他领域的进步。因此，本次会议将通过建立网络和发起合作来加强基础设施，推动这一令人兴奋的领域向前发展。会议还将促进以下教育效益：使新到实地的受训人员和调查人员熟悉最新的技术；关键的科学反馈；培训生和新研究人员的职业发展，包括有机会看到成功的科学家展示前沿科学，并与未来的导师和其他可能有助于他们的科学和专业发展的人建立联系。技术摘要：“植物受体激酶”专题讨论会有以下主要目标：1)促进植物RK研究的加强发展；2)为研究生和博士后提供展示成果并与该领域权威人士互动的机会。因此，组织者dr。Cyril Zipfel（英国塞恩斯伯里实验室）和Steven C. Huber（美国农业部/美国农业研究所，伊利诺伊大学厄巴纳-香槟分校）设计了这个项目，汇集了世界各地的领导者，他们共同涵盖了对植物RK研究具有重要意义的广泛主题。每次会议还将包括一个或多个从贡献摘要中选择的演讲，让学生和博士后有机会参与海报会议之外的计划，并捕捉最广泛的令人兴奋的新发展。由于酪氨酸磷酸化是植物RK生物学中的一个新兴主题，会议将以动物受体酪氨酸激酶信号传导领域的专家（Mark Lemmon博士）的重点演讲开始。接下来的个别会议将依次介绍RK在生长基础方面的研究现状，并特别关注brassinosteroids INSENSITIVE 1 (BRI1) RK，它在生长中起作用，是研究最多的植物RK之一。然后，RK复合物的功能和组成将与通过分泌和内吞途径进行贩运的补充主题一起发展。研讨会1的重点是植物RKs的结构方面，将加强在分子水平上理解机制的努力。在此基础上，后续课程将探讨RKs在特定发育过程（如气孔发育）和微生物相互作用（有益和致病）中的作用。第二场研讨会将重点介绍最新的蛋白质组学方法来研究RK的活性和功能，最终在转化RK科学和进化方面达到高潮。召开这次会议的时机正合适，因为有关酪氨酸磷酸化在RK功能中的重要性的新结果正在出现；植物RKs的胞外结构域和胞质结构域的作用；贩运朝鲜人口的复杂性；以及除了致病微生物外有益微生物相互作用的重要性。这种主题的多样性通常不会在一次会议中涉及。重要的是，在项目设计中包含了充足的讨论时间，以允许参与者确定共同利益并建立跨领域的新合作。

Plants are under constant pressure to respond rapidly and accurately to changing environmental and developmental conditions and must rapidly translate extracellular signals into appropriate intracellular responses. Cell surface receptor kinases (RKs) are one of the major components in this extracellular sensing. Plants show a huge expansion of the RK family compared to animals. However, only a very limited number of plant RKs have an assigned function, but those characterized control critical aspects ranging from development to responses to biotic and abiotic stresses. The 2015 Keystone Symposia meeting on "Plant Receptor Kinases: From Molecules to Environment" will highlight recent developments in our understanding of RKs, from their evolution and the pathways they are involved in, to the molecular details underlying their function and thereby provide the platform for discussions of emerging themes. The processes controlled by plant RKs include gas exchange, innate immunity, establishment of beneficial symbioses, and control of intrinsic growth/yield. Thus, there are many direct implications for plant performance in the field and at the ecosystem level, and the meeting will be of broad interest to scientists in academia, government and the private sector. The diversity of topics presented at this meeting is typically not covered within a single meeting. Other meetings, by necessity, focus on specific areas while this Keystone Symposia meeting will bring together world-leaders in their respective areas and, by sharing latest research findings and new experimental approaches/methods, will facilitate advances in other areas as well. As such, this meeting will enhance infrastructure by fostering networking and initiation of collaborations that will move this exciting field forward. The meeting will also further the following educational benefits: acquaint trainees and investigators new to field with the state-of-the-art; critical scientific feedback; and career development for trainees and new investigators, including opportunities both to see successful scientists presenting cutting-edge science and to network with prospective mentors and others who might contribute to their scientific and professional development.Technical Summary:The Keystone Symposia scientific conference on "Plant Receptor Kinases" has the following principal objectives: 1) to facilitate enhanced development of plant RK research; and 2) to provide opportunities for graduate students and postdocs to present results and interact with authorities in the field. Thus, the organizers, Drs. Cyril Zipfel (Sainsbury Laboratory, UK) and Steven C. Huber (USDA/ARS, University of Illinois at Urbana-Champaign), have designed the program to bring together world-leaders that collectively cover a wide range of topics that are of fundamental importance to plant RK research. Each session will also include one or more talks selected from the contributed abstracts to give students and postdocs the opportunity to participate in the program beyond a poster session and to capture the widest range of exciting new developments. Because tyrosine phosphorylation is an emerging theme in plant RK biology, the meeting will start with a key note address by an expert (Dr. Mark Lemmon) in the area of animal receptor tyrosine kinase signaling. The individual sessions that follow will then sequentially present the status of RK research in fundamental aspects of growth with some specific focus on the BRASSINOSTEROID INSENSITIVE 1 (BRI1) RK, which functions in growth and is one of the most studied plant RKs. The function and composition of RK complexes will then be developed along with the complementary topic of trafficking through the secretory and endocytic pathways. The focus of Workshop I on structural aspects of plant RKs will enhance efforts to understand mechanisms at the molecular level. With this foundation, subsequent sessions will explore the role of RKs in specific developmental programs (e.g., stomatal development) and microbe interactions (both beneficial and pathogenic). The second Workshop will highlight state-of-the-art proteomic approaches to study RK activity and function, culminating in a final session of translational RK science and evolutionary aspects. The time is right for this meeting as new results are emerging relating to the importance of tyrosine phosphorylation in RK function; the role of structure of extracellular and cytoplasmic domains of plant RKs; the complexities of RK trafficking; and the importance of beneficial microbial interactions in addition to pathogenic microbes. This diversity of topics is typically not covered within a single meeting. Importantly, ample discussion time is included in the program design to allow participants to identify common interests and forge new collaborations spanning areas.