Meeting: Keystone Symposia on "Plant Receptor Kinases" to be held in Taos, NM from February 8-13, 2015

植物承受着持续不断的压力，必须对不断变化的环境和发育条件做出快速和准确的反应，必须迅速将细胞外信号转化为适当的细胞内反应。细胞表面受体激酶(RKS)是这种细胞外感觉的主要成分之一。与动物相比，植物显示了RK家族的巨大扩张。然而，只有数量非常有限的植物RK具有指定的功能，但那些具有特征的RK控制着从发育到对生物和非生物胁迫的反应的关键方面。2015年的Keystone研讨会主题为“植物受体激酶：从分子到环境”，将突出我们对RKS的理解的最新进展，从它们的进化和参与的途径，到它们功能的分子细节，从而为讨论新出现的主题提供平台。植物RKS控制的过程包括气体交换、先天免疫、有益共生的建立和内在生长/产量的控制。因此，对田间和生态系统层面的植物表现有许多直接影响，这次会议将引起学术界、政府和私营部门科学家的广泛兴趣。在这次会议上提出的议题的多样性通常不会在一次会议中讨论。其他会议必然侧重于具体领域，而这次Keystone研讨会会议将把各自领域的世界领导人聚集在一起，并通过分享最新研究成果和新的实验途径/方法，也将促进其他领域的进展。因此，这次会议将通过促进联网和启动合作来加强基础设施，从而推动这一令人兴奋的领域向前发展。会议还将进一步促进以下教育益处：使新接触该领域的受训者和研究人员熟悉最新技术；关键的科学反馈；以及受训者和新研究人员的职业发展，包括看到成功的科学家展示尖端科学并与未来的导师和其他可能对他们的科学和专业发展做出贡献的人建立网络的机会。技术总结：Keystone研讨会关于“植物受体激酶”的科学会议有以下主要目标：1)促进植物RK研究的进一步发展；2)为研究生和博士后提供机会，展示结果并与该领域的当局进行互动。因此，组织者Cyril Zipfel博士(英国塞恩斯伯里实验室)和Steven C.Huber博士(美国农业部/ARS，伊利诺伊大学厄巴纳-香槟分校)设计了该项目，将世界领导人聚集在一起，共同涵盖对植物RK研究至关重要的广泛主题。每堂课还将包括从投稿摘要中挑选的一场或多场演讲，让学生和博士后有机会参与到海报课程之外的项目中，并捕捉最广泛的令人兴奋的新发展。由于酪氨酸磷酸化是植物RK生物学中的一个新兴主题，会议将首先由动物受体酪氨酸激酶信号领域的一位专家(Mark Lemmon博士)发表重要讲话。随后的个别会议将按顺序介绍RK在生长的基本方面的研究现状，并特别关注油菜素类固醇不敏感1(BRI1)RK，它在生长中起作用，是研究最多的植物RKS之一。RK复合体的功能和组成将与通过分泌和内吞途径运输的补充主题一起开发。第一次研讨会的重点是植物RKS的结构方面，这将加强在分子水平上了解机制的努力。在此基础上，后续的会议将探讨RKS在特定发育程序(例如，气孔发育)和微生物相互作用(有益和致病)中的作用。第二次研讨会将重点介绍研究RK活性和功能的最新蛋白质组学方法，最终将在翻译RK科学和进化方面的最后一次会议上达到高潮。这次会议的时机恰到好处，因为新的结果正在出现，涉及到酪氨酸磷酸化在RK功能中的重要性；植物RKS胞外和细胞质结构的作用；RK运输的复杂性；以及除了病原微生物外，有益微生物相互作用的重要性。这种多样化的议题通常不会在一次会议中得到讨论。重要的是，在项目设计中包括了充足的讨论时间，使参与者能够确定共同的兴趣并建立跨领域的新合作。

Plants are under constant pressure to respond rapidly and accurately to changing environmental and developmental conditions and must rapidly translate extracellular signals into appropriate intracellular responses. Cell surface receptor kinases (RKs) are one of the major components in this extracellular sensing. Plants show a huge expansion of the RK family compared to animals. However, only a very limited number of plant RKs have an assigned function, but those characterized control critical aspects ranging from development to responses to biotic and abiotic stresses. The 2015 Keystone Symposia meeting on "Plant Receptor Kinases: From Molecules to Environment" will highlight recent developments in our understanding of RKs, from their evolution and the pathways they are involved in, to the molecular details underlying their function and thereby provide the platform for discussions of emerging themes. The processes controlled by plant RKs include gas exchange, innate immunity, establishment of beneficial symbioses, and control of intrinsic growth/yield. Thus, there are many direct implications for plant performance in the field and at the ecosystem level, and the meeting will be of broad interest to scientists in academia, government and the private sector. The diversity of topics presented at this meeting is typically not covered within a single meeting. Other meetings, by necessity, focus on specific areas while this Keystone Symposia meeting will bring together world-leaders in their respective areas and, by sharing latest research findings and new experimental approaches/methods, will facilitate advances in other areas as well. As such, this meeting will enhance infrastructure by fostering networking and initiation of collaborations that will move this exciting field forward. The meeting will also further the following educational benefits: acquaint trainees and investigators new to field with the state-of-the-art; critical scientific feedback; and career development for trainees and new investigators, including opportunities both to see successful scientists presenting cutting-edge science and to network with prospective mentors and others who might contribute to their scientific and professional development.Technical Summary:The Keystone Symposia scientific conference on "Plant Receptor Kinases" has the following principal objectives: 1) to facilitate enhanced development of plant RK research; and 2) to provide opportunities for graduate students and postdocs to present results and interact with authorities in the field. Thus, the organizers, Drs. Cyril Zipfel (Sainsbury Laboratory, UK) and Steven C. Huber (USDA/ARS, University of Illinois at Urbana-Champaign), have designed the program to bring together world-leaders that collectively cover a wide range of topics that are of fundamental importance to plant RK research. Each session will also include one or more talks selected from the contributed abstracts to give students and postdocs the opportunity to participate in the program beyond a poster session and to capture the widest range of exciting new developments. Because tyrosine phosphorylation is an emerging theme in plant RK biology, the meeting will start with a key note address by an expert (Dr. Mark Lemmon) in the area of animal receptor tyrosine kinase signaling. The individual sessions that follow will then sequentially present the status of RK research in fundamental aspects of growth with some specific focus on the BRASSINOSTEROID INSENSITIVE 1 (BRI1) RK, which functions in growth and is one of the most studied plant RKs. The function and composition of RK complexes will then be developed along with the complementary topic of trafficking through the secretory and endocytic pathways. The focus of Workshop I on structural aspects of plant RKs will enhance efforts to understand mechanisms at the molecular level. With this foundation, subsequent sessions will explore the role of RKs in specific developmental programs (e.g., stomatal development) and microbe interactions (both beneficial and pathogenic). The second Workshop will highlight state-of-the-art proteomic approaches to study RK activity and function, culminating in a final session of translational RK science and evolutionary aspects. The time is right for this meeting as new results are emerging relating to the importance of tyrosine phosphorylation in RK function; the role of structure of extracellular and cytoplasmic domains of plant RKs; the complexities of RK trafficking; and the importance of beneficial microbial interactions in addition to pathogenic microbes. This diversity of topics is typically not covered within a single meeting. Importantly, ample discussion time is included in the program design to allow participants to identify common interests and forge new collaborations spanning areas.