Keystone Symposia Annual Meeting Series on Obesity

鼎石肥胖研讨会系列年会

• 批准号: 9208131
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-21 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9208131
• 关键词: Address; Area; Bioenergetics; Biology; British Columbia; Canada; Cells; Cellular biology; Chronic; Clinical; Collaborations; Comorbidity; Coronary; Coupling; Dietary Factors; Discipline; Disease; Energy Metabolism; Environment; Environmental Risk Factor; Fostering; Future; Genetic; Homeostasis; Incidence; Inherited; Instruction; Interdisciplinary Study; Knowledge; Life Expectancy; Link; Liver; Medical; Metabolic; Metabolic Control; Metabolic Diseases; Metabolic syndrome; Metabolism; Methodology; Mitochondria; Mitochondrial Diseases; Molecular; Morphology; Muscle; Muscle function; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pathogenesis; Peripheral; Physiology; Prevalence; Research; Research Personnel; Role; Scientist; Series; System; Tissues; Transcend; Translating; Vascular Diseases; base; career; clinical practice; collaborative environment; design; innovation; insight; interest; liver metabolism; meetings; mitochondrial dysfunction; multidisciplinary; non-alcoholic; non-alcoholic fatty liver; novel; novel strategies; novel therapeutics; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): Support is requested for a series of annual Keystone Symposia meetings on the topic of Obesity. The first meeting in the series will be held in 2015 and is entitled Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure, and is being organized by Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer. The meeting will be held in Whistler, British Columbia, Canada from March 22-27, 2015. A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co- morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology, and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. Keystone Symposia's 2015 meeting on Obesity and the Metabolic Syndrome will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, mitochondrial and cell biology, physiology and clinicians with an interest in metabolic disease, to foster innovative ideas in this area. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Liver Metabolism and Nonalcoholic Fatty Liver Disease, which will share a plenary session with this meeting.

描述（由申请人提供）：请求支持一系列有关肥胖主题的年度 Keystone 研讨会。该系列的第一次会议将于 2015 年举行，题为“肥胖和代谢综合症：线粒体和能量消耗”，由 Johan Auwerx、Eleftheria Maratos-Flier 和 Thomas Langer 组织。会议将于2015年3月22日至27日在加拿大不列颠哥伦比亚省惠斯勒举行。21世纪的医学挑战是预期寿命的空前增长与慢性多因素疾病发病率和患病率的大幅增加相结合。典型的疾病例子包括代谢紊乱，例如肥胖和2型糖尿病，这些疾病通常与合并症相关，包括非酒精性肝病以及冠状动脉、外周和中枢血管疾病。一系列疾病通常统称为代谢综合征。在过去的十年中，越来越明显的是，细胞代谢的变化通常与线粒体的数量、形态和功能的变化有关，并且这些细胞变化是全身代谢异常的基础，而全身代谢异常是代谢综合征的许多临床特征的特征。 Keystone Symposia 2015 年肥胖与代谢综合征会议将讨论将肝脏、肌肉和肠道等外周组织中的线粒体功能与代谢综合征的全身异常联系起来的新发现。将审查确定基于改变线粒体功能的新疗法的潜力。由于线粒体功能现在被认为除了在细胞水平上控制能量稳态之外，还可以在有机体水平上控制代谢稳态，这次会议将创建一个真正的跨学科环境，将生物能量学领域的基础科学家聚集在一起， 对代谢疾病感兴趣的线粒体和细胞生物学、生理学和临床医生， 培育该领域的创新理念。同期举行的肝脏代谢和非酒精性脂肪性肝病会议将大大增加跨学科互动的机会，该会议将与本次会议共享全体会议。