Keystone Symposia Annual Meeting Series on Diabetes

描述（由申请人提供）：要求支持一系列关于糖尿病主题的年度Keystone专题会议。该系列的第一次会议将于2015年举行，题为“糖尿病和代谢功能障碍”，由Jeffrey E. Pessin, Alan R. Saltiel和Deborah M. Muoio组织。会议将于2015年1月27日至2月1日在新墨西哥州圣达菲举行。2015年的会议将讨论分子、细胞、组织和综合系统代谢的几个前沿方面，这些方面解释了糖尿病和肥胖症中发生的代谢缺陷。其中几个主题与线粒体、代谢和心力衰竭会议重叠，计划同时举行四个会议。这些同步会议将讨论正常和失调肌肉（骨骼和心脏）细胞内信号，线粒体功能/动力学，衰老和能量平衡的独特和新颖方面。会议组织者选择了这些各自领域的领导者，他们不仅将解决模型系统中的基本和综合机制，而且还将解决人类病理学中的这些问题。糖尿病特异性会议(4)反映了代谢失调的几个关键方面，其中新的信息正在出现，导致我们之前对这些过程的理解发生范式转变。其中包括关于组织串扰的新信息，选择性胰岛素抵抗背后的葡萄糖产生和脂肪酸合成控制之间的相互关系，以及正常和失调的昼夜节律在代谢过程中的作用。这些新的前沿进展将为未来新的研究方向提供新颖和令人兴奋的新发现。

DESCRIPTION (provided by applicant): Support is requested for a series of annual Keystone Symposia meetings on the topic of Diabetes. The first meeting in the series will be held in 2015 and is entitled Diabetes and Metabolic Dysfunction, and is being organized by Jeffrey E. Pessin, Alan R. Saltiel and Deborah M. Muoio. The meeting will be held in Santa Fe, New Mexico from January 27 - February 1, 2015. The 2015 meeting will address several cutting edge aspects of molecular, cellular, tissue and integrative system metabolism that account for the metabolic defects that occur in diabetes and obesity. Several of these themes overlap with the concurrent meeting on Mitochondria, Metabolism and Heart Failure and four concurrent sessions are planned. These concurrent sessions will address distinct and novel aspects of normal and dysregulation muscle (skeletal and cardiac) intracellular signaling, mitochondria function/dynamics, aging and energy balance. The meeting organizers have selected leaders in each of these respective areas that will not only address basic and integrative mechanisms in model systems, but several will address these issues in human pathology. The diabetes-specific sessions (4) reflect several key aspects of metabolic dysregulation in which novel information is currently forthcoming causing a paradigm shift in over our previous understanding of these processes. These include new information about tissue cross-talk, the inter-relationship between the control of glucose production and fatty acid synthesis that underlies selective insulin resistance and the role of normal and dysregulated circadian rhythms on metabolic processes. These new cutting-edge advances will provide novel and exciting new findings for the basis of new future research directions.