Keystone Symposia Annual Meeting Series on Obesity

描述（由申请人提供）：支持要求一系列的年度基石研讨会会议上的主题肥胖。该系列的第一次会议将于2015年举行，题为肥胖和代谢综合征：线粒体和能量消耗，由Johan Auwerx，Eleftheria Maratos-Flier和托马斯兰格组织。会议将于2015年3月22日至27日在加拿大不列颠哥伦比亚省惠斯勒举行。21世纪世纪的一个医学挑战是预期寿命的空前增长与慢性多因素疾病的发病率和流行率的大幅增加相结合。典型的疾病实例包括代谢障碍，例如肥胖和2型糖尿病，其通常与包括非酒精性肝病和冠状动脉、外周和中心血管疾病的共病相关。代谢综合征通常被称为代谢综合征。在过去的十年中，很明显，细胞代谢的变化往往与线粒体的数量，形态和功能的变化有关，这些细胞变化是全身代谢异常的基础，这些代谢异常是代谢综合征的许多临床特征的特征。Keystone Symposia 2015年肥胖和代谢综合征会议将讨论将外周组织（如肝脏、肌肉和肠道）中的线粒体功能与代谢综合征的全身异常联系起来的新发现。将审查确定新的治疗方法的基础上修改线粒体功能的潜力。由于线粒体功能现在被认为除了在细胞水平上控制能量稳态外，还在生物体水平上控制代谢稳态，因此这次会议将创造一个真正的跨学科环境，将生物能量学领域的基础科学家聚集在一起， 线粒体和细胞生物学、生理学和对代谢疾病感兴趣的临床医生， 在这方面提出创新的想法。跨学科互动的机会将通过肝脏代谢和非酒精性脂肪肝同时举行的会议得到显着增强，该会议将与本次会议共享全体会议。

DESCRIPTION (provided by applicant): Support is requested for a series of annual Keystone Symposia meetings on the topic of Obesity. The first meeting in the series will be held in 2015 and is entitled Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure, and is being organized by Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer. The meeting will be held in Whistler, British Columbia, Canada from March 22-27, 2015. A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co- morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology, and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. Keystone Symposia's 2015 meeting on Obesity and the Metabolic Syndrome will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, mitochondrial and cell biology, physiology and clinicians with an interest in metabolic disease, to foster innovative ideas in this area. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Liver Metabolism and Nonalcoholic Fatty Liver Disease, which will share a plenary session with this meeting.