Biological Cell Lasers

生物细胞激光器

• 批准号: 1505569
• 负责人: Seok (Andy) Yun
• 金额: $ 45万
• 依托单位: Massachusetts General Hospital
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1505569&HistoricalAwards=false
• 关键词: Biological; Cell; Lasers

Abstract Title: Biological cell lasersAbstract: Non-technical: Since the first laser human ever made was demonstrated a half century ago, numerous types of lasers have been developed and made a tremendous impact on modern science and technology. In medicine and biology, various lasers have been adopted and being applied. For example, lasers allow physicians to remove diseased tissues, seal damaged areas with high precision, and activate drugs in specific target organs for treatments. In all these cases, lasers are commonly used as devices and instruments that are separate from the patients. The goal of the proposed research is to invent a new type of laser that is made biologically compatible and readily amenable to living organisms and human body. Such bio-lasers can be integrated into the biological systems and thereby have a potential to offer new ways of using laser light in biomedical sensing and diagnosis, as well as therapy. This project also provides the opportunity to educate and train graduate students and postdoctoral fellows in the highly vibrant and multidisciplinary environment at the Wellman Center for Photomedicine. The graduate students and undergraduate students will have the opportunity to participate in this project, learn how to work across boundaries between disciplines through creativity and inspiration, and present their research in a conference, with support from this project. The outcome of this project is expected to inspire the general public, particularly children, and make them aware of the far-reaching impact and joy of science. Technical: The previous NSF funding led to the first biological laser based on single human cells or bacteria. This proposed project will push the envelop of the field to the next significant level, with two specific aims to develop (1) microfluidic cell laser-on-a-chip with high controllability and high throughput for applications to intracellular sensing and cytometry and (2) stand-alone cell lasers that are operational in tissue without external cavities. This project continues to explore the new territory in the field of laser and show how the unique properties of cell lasers can be harnessed to develop novel photonic devices and technologies. The experimental approach is highly interdisciplinary as it brings together physical and biological sciences and engineering. This work will increase our understanding about the design, operation, and applications of cell lasers, and points to a way to realize "living laser", where all three basic elements, i.e. amplification, resonance, and pumping, are achieved with biological materials in vivo. The intrinsically biocompatible cell laser has the potential to make a transformative impact on the way light is used in biomedical applications. For example, lasing within the tissues and inside the cells may offer new possibilities of intracellular sensing and nonlinear microscopy for biological analysis and medical diagnosis. The ability to generate laser light in vivo may enable new approaches in light-controlled therapy and drug activation.

摘要标题：生物细胞Lasersabstract：非技术性：自从有史以来第一个激光人类制作的第一个激光人已经证明了一个半个世纪前，已经开发了许多类型的激光，并对现代科学和技术产生了巨大影响。在医学和生物学上，已经采用了各种激光并应用了。例如，激光允许医生去除患病的组织，以高精度密封受损区域，并激活特定目标器官中的药物进行治疗。在所有这些情况下，激光通常用作与患者分开的设备和仪器。拟议的研究的目的是发明一种新型的激光器，该激光器在生物学上兼容，并且很容易与生物体和人体合适。这样的生物激光器可以整合到生物系统中，从而有可能在生物医学感应和诊断以及治疗中提供新的方法来使用激光光。该项目还提供了机会，可以在Wellman摄影医学中心在高度充满活力和多学科环境中教育和培训博士学生和博士后研究员。研究生和本科生将有机会参与该项目，学习如何通过创造力和灵感来跨学科之间的界限，并在该项目的支持下在会议上介绍他们的研究。该项目的结果有望激发公众，尤其是儿童，并使他们意识到科学的深远影响和喜悦。技术：先前的NSF资金导致基于单个人类细胞或细菌的第一个生物激光。 This proposed project will push the envelop of the field to the next significant level, with two specific aims to develop (1) microfluidic cell laser-on-a-chip with high controllability and high throughput for applications to intracellular sensing and cytometry and (2) stand-alone cell lasers that are operational in tissue without external cavities.该项目继续探索激光领域的新领域，并展示如何利用细胞激光器的独特性能来开发新型的光子设备和技术。实验方法是高度跨学科的，因为它汇集了物理和生物科学和工程。这项工作将提高我们对细胞激光器的设计，操作和应用的理解，并指出一种实现“活激光”的方法，其中所有三个基本元素（即使用生物材料在Vivo中都可以实现，即放大，共振和抽水。本质上生物相容性的细胞激光器具有对生物医学应用中光的方式的变革性影响。例如，在组织内部和细胞内部的激光可能会提供细胞内感测和非线性显微镜的新可能性，用于生物分析和医学诊断。在体内产生激光光的能力可以实现光照疗法和药物激活的新方法。