UNS:Multiresonator Photonic Crystal Enhanced Fluorescence and SERS

Cunningham，Brian 1512043该提案的目标是开发一种新的方法，用于将多个光学腔耦合在一起，以增强用于生物和化学检测的荧光发射体的激发。 波长调谐的外腔激光器、光子晶体谐振器表面和金纳米棒相结合，可以实现蛋白质的大幅度增强荧光检测。基于表面的荧光分析和表面增强拉曼散射（Sers）广泛应用于生命科学研究、分子诊断和显微镜检查。有强烈的动机来提高它们的检测灵敏度，同时降低检测仪器的成本/复杂性。该项目将开发和表征一种全新的方法，用于激发表面吸附的光子发射体和散射体，可应用于生命科学研究，基因组学，蛋白质组学，诊断学和环境监测中使用的生物分子分析物的表面荧光和Sers分析。 该方法结合了廉价的可制造的纳米结构表面和一个nexpensive，紧凑的检测仪器，将促进广泛采用。该项目涉及研究生研究，本科生实习，实验室演示到本科课程的整合，以及涉及动手示范给中学生的活动。

AbstractCunningham, Brian1512043The goal of this proposal is to develop a novel approach for coupling multiple optical cavities together to enhance the excitation of fluorescent emitters used for biological and chemical detection. Wavelength-tuned external cavity lasers, photonic crystal resonator surfaces, and gold nanorods are combined to demonstrate large enhanced fluorescence detection of proteins.Surface-based fluorescence assays and surface enhanced Raman scattering (SERS) are widely used in life science research, molecular diagnostics, and microscopy. There is strong motivation to improve their detection sensitivity while at the same time reducing the cost/complexity of detection instrumentation. This project would develop and characterize a fundamentally new approach towards excitation of surface-adsorbed photon emitters and scatterers that can be applied towards surface-based fluorescent and SERS assays for biomolecular analytes used in life science research, genomics, proteomics, diagnostics, and environmental monitoring. The approach incorporates inexpensively manufacturable nanostructured surfaces and an nexpensive, compact detection instrument that will facilitate broad adoption. The project involves graduate research, undergraduate internships, integration of laboratory demonstrations into undergraduate courses, and activities that involve hands-on demonstrations to middle school children.