UNS:Multiresonator Photonic Crystal Enhanced Fluorescence and SERS

Cunningham，Brian1512043这项提议的目标是开发一种新的方法，将多个光腔耦合在一起，以增强用于生物和化学检测的荧光发射体的激发。波长调谐的外腔激光器、光子晶体谐振器表面和金纳米棒相结合，展示了蛋白质的大规模增强荧光检测。基于表面的荧光分析和表面增强拉曼散射(SERS)在生命科学研究、分子诊断和显微技术中被广泛应用。有强烈的动机提高它们的检测灵敏度，同时降低检测仪器的成本/复杂性。该项目将开发和表征一种激发表面吸附的光子发射体和散射体的全新方法，该方法可用于生物分子分析的表面荧光和表面增强拉曼散射分析，用于生命科学研究、基因组学、蛋白质组学、诊断学和环境监测。该方法结合了可廉价制造的纳米结构表面和廉价、紧凑的检测仪器，将有助于广泛采用。该项目包括研究生研究、本科生实习、将实验室演示整合到本科课程中，以及涉及中学生动手演示的活动。

AbstractCunningham, Brian1512043The goal of this proposal is to develop a novel approach for coupling multiple optical cavities together to enhance the excitation of fluorescent emitters used for biological and chemical detection. Wavelength-tuned external cavity lasers, photonic crystal resonator surfaces, and gold nanorods are combined to demonstrate large enhanced fluorescence detection of proteins.Surface-based fluorescence assays and surface enhanced Raman scattering (SERS) are widely used in life science research, molecular diagnostics, and microscopy. There is strong motivation to improve their detection sensitivity while at the same time reducing the cost/complexity of detection instrumentation. This project would develop and characterize a fundamentally new approach towards excitation of surface-adsorbed photon emitters and scatterers that can be applied towards surface-based fluorescent and SERS assays for biomolecular analytes used in life science research, genomics, proteomics, diagnostics, and environmental monitoring. The approach incorporates inexpensively manufacturable nanostructured surfaces and an nexpensive, compact detection instrument that will facilitate broad adoption. The project involves graduate research, undergraduate internships, integration of laboratory demonstrations into undergraduate courses, and activities that involve hands-on demonstrations to middle school children.