Photonic resonator hybrids for ultrasensitive biosensing

用于超灵敏生物传感的光子谐振器混合体

• 批准号: 1900277
• 负责人: Brian Cunningham
• 金额: $ 60万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900277&HistoricalAwards=false
• 关键词: Photonic; resonator; hybrids; ultrasensitive; biosensing

The aim of this application is to construct and test the performance of a new generation of light-controlling materials called photonic hypercrystals (PHC). This project builds upon the initial success of the investigators toward developing a new generation of fluorescence sensors with a detection limit and high dynamic range that have not been demonstrated in the past. They demonstrated the feasibility of the proposed application as evidenced by the outstanding performance of the proposed optical hybrid materials for the detection of a fluorescence signal with a very high degree of sensitivity. This project will potentially lead to a new class of highly novel sensors that can significantly improve the limit of detection of biomarkers of diseases. This can lead to the availability of highly sensitive, compact and low-cost fluorescence sensors for low-cost integrated diagnostic tools for biomedical and clinical applications.Successful development of the proposed detection technique could have a significant impact on the development of highly sensitive detectors and instrumentation that could be used to develop novel biosensors and improve the performance an reduce the cost of existing bio-imaging and sensing platforms that detect and quantify fluorescence signals from biomolecules. The investigating team has outstanding records for teaching and training of students and research fellows in the fields of engineering, chemistry, biophotonics, biosensors, and nanotechnology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该应用程序的目的是构建和测试新一代光控材料的性能，称为光子超晶体（PHC）。 该项目建立在研究人员开发新一代荧光传感器的初步成功的基础上，该传感器具有过去未被证明的检测限和高动态范围。他们证明了所提出的应用的可行性，如所提出的光学混合材料用于以非常高的灵敏度检测荧光信号的出色性能所证明的。该项目将有可能导致一类新的高度新颖的传感器，可以显着提高疾病生物标志物的检测极限。这可以导致高度敏感的、所提出的检测技术的成功开发可能对高灵敏度检测器和仪器的开发产生重大影响，这些检测器和仪器可用于开发新型生物传感器，并提高性能，降低现有生物传感器的成本。成像和传感平台，检测和量化来自生物分子的荧光信号。该研究团队在工程、化学、生物光子学、生物传感器和纳米技术领域的学生和研究人员的教学和培训方面有着出色的记录。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing.

• DOI: 10.1038/s41467-022-32387-w
• 发表时间: 2022-08-08
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Xiong, Yanyu;Huang, Qinglan;Canady, Taylor D.;Barya, Priyash;Liu, Shengyan;Arogundade, Opeyemi H.;Race, Caitlin M.;Che, Congnyu;Wang, Xiaojing;Zhou, Lifeng;Wang, Xing;Kohli, Manish;Smith, Andrew M.;Cunningham, Brian T.
• 通讯作者: Cunningham, Brian T.

L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis.

L-普拉斯汀增强了NLRP3炎性体组装和博来霉素诱导的肺纤维化。

• DOI: 10.1016/j.celrep.2022.110507
• 发表时间: 2022-03-15
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Joshi H;Almgren-Bell A;Anaya EP;Todd EM;Van Dyken SJ;Seth A;McIntire KM;Singamaneni S;Sutterwala F;Morley SC
• 通讯作者: Morley SC

Accelerated Digital Biodetection Using Magneto-plasmonic Nanoparticle-Coupled Photonic Resonator Absorption Microscopy

• DOI: 10.1021/acsnano.1c08569
• 发表时间: 2022-01-18
• 期刊: ACS NANO
• 影响因子: 17.1
• 作者: Che, Congnyu;Xue, Ruiyang;Cunningham, Brian T.
• 通讯作者: Cunningham, Brian T.

High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay.

• DOI: 10.1016/j.crmeth.2022.100267
• 发表时间: 2022-08-22
• 期刊: Cell reports methods

Ultrasensitive lateral-flow assays via plasmonically active antibody-conjugated fluorescent nanoparticles

• DOI: 10.1038/s41551-022-01001-1
• 发表时间: 2023-02-02
• 期刊: NATURE BIOMEDICAL ENGINEERING
• 影响因子: 28.1
• 作者: Gupta, Rohit;Gupta, Prashant;Singamaneni, Srikanth
• 通讯作者: Singamaneni, Srikanth