EAGER: Lab-in-a-Smartphone

提议：1447893PI：Cunningham，BrianInstitution：伊利诺伊大学香槟分校标题：EIGER：Lab-in-a-Smartphone意义：低成本、强大和多模式生物传感器检测能力的广泛可获得性将刺激在实验室能力不足或当前封闭平台仅针对非常特定的商业市场的各种环境中传感应用的加速发展。基于智能手机的检测系统有望在实验室设施不可用的情况下找到应用，例如家庭、诊所、农场或偏远地点的看护点分析。拟议工作中开发的综合方法将使移动传感应用得以实现，这些应用包括通过传感特定生物标记物蛋白质(心脏、癌症和其他)进行疾病诊断、特定传染病(病毒或细菌，如通过聚合酶链式反应执行)的识别、食品中过敏原的传感、食品/药品制造质量控制、假药传感、呼气分析和空气/水/土壤资源的环境监测情报描述：这项急切的提议的目标是利用集成半导体激光二极管和LED作为智能手机内的光源，以及薄膜波导/光栅耦合器来为样品带来光。该系统只需将待测样品放在分析开口上即可运行，而定制软件应用程序则控制测量的所有其他方面。该系统将能够进行UV/可见光波长吸收光谱、UV/可见光波长反射光谱、拉曼光谱、表面增强拉曼光谱和无标记光学生物传感器测量。该平台将使用定制的微流控墨盒，旨在执行样品准备、液体混合和细胞/生物分子分析的其他步骤，这些步骤可以由移动应用程序开发商的整个生态系统开发。

Proposal: 1447893PI: Cunningham, BrianInstitution: University of Illinois at Urbana-ChampaignTitle: EAGER: Lab-in-a-SmartphoneSignificance:The wide availability of a low-cost, robust, and multimode biosensor detection capability will spur accelerated development of sensing applications in myriad settings where laboratory capabilities are lacking, or where current closed platforms are aimed at only a very specific commercial market. Smartphone-based detection systems are expected to find applications in situations where laboratory facilities are not available such as point-of-care analysis in the home, clinic, farm, or remote locations. The integrated approach to be developed in the proposed work would enable mobile sensing applications that include diagnosis of disease through sensing of specific biomarker proteins (cardiac, cancer, and others), specific identification of infectious disease (viral or bacterial, as performed by PCR), sensing of allergens in food, food/drug manufacturing quality control, sensing of counterfeit drugs, breath analysis, and environmental monitoring of air/water/soil resourcesIntellectual Description:The goal of this EAGER proposal is to utilize integrated semiconductor laser diodes and LEDs as illumination sources within the smartphone, and a thin film waveguide/grating coupler to bring light to the sample. The system will operate simply by placing the sample-under-test over the analysis opening, while a custom software application controls all other aspects of the measurement. The resulting system will be capable of performing UV/Visible wavelength absorption spectroscopy, UV/Visible wavelength reflectance spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, and label-free optical biosensor measurements. The platform will use custom microfluidic cartridges designed to perform sample preparation, liquid mixing, and other steps of cell/biomolecular assays that can be developed by the entire ecosystem of mobile application developers.