UNS:Integrating nanoparticle design and in vivo testing to proactively reduce environmental impacts

标题：整合纳米颗粒设计和体内测试，以主动减少环境影响PI：Tanguay，Robert L.研究机构：俄勒冈州州立大学和俄勒冈大学近年来在开发更安全的纳米颗粒（NP）的基本设计原理方面取得了进展。虽然我们现在了解到材料成分在控制某些材料的毒性方面起着重要作用，但人们越来越意识到，在考虑生物相容性时，表面特性特别重要。目前尚不清楚官能团的特性和配体密度如何影响毒性。该项目将系统地探索调节配体壳的组成、多样性和密度在管理生物相容性中的作用。拟议工作的影响将是多方面的。首先，该研究的产品将使研究人员能够将发现的分子水平设计准则作为推进材料设计的基础。精密图书馆将作为nanoEHS研究社区的新参考资料，从而利用跨学科的基础和应用研究人员的活动。社会将受益于未来产品对健康和环境的负面影响的减少。最后，研究团队将利用该项目的综合性质，为本科生和研究生提供动态的多学科教育体验。合作PI和学生将不仅与同事沟通，而且与更广泛的公众成员。后一个目标将通过针对K-12观众的动手和在线演示来实现。PI将开发精确工程NP库，这些库专门设计用于定义NP表面对生物相容性的重要性。为了提高生物相容性措施的相关性和灵敏度，他们将使用高通量多维胚胎斑马鱼系统。确定亲合力和毒性之间的关系将为可能出现在下一代应用中的配体混合物的使用提供信息。

Title: Integrating nanoparticle design and in vivo testing to proactively reduce environmental impactsPI: Tanguay, Robert L. and Hutchison, James E.Institution: Oregon State University and the University of OregonThere has been progress in recent years in developing basic design principles for safer nanoparticles (NPs). Although we now understand that material composition plays an important role in governing the toxicity of some materials, there is increased awareness that surface properties are particularly important when considering biocompatibility. It remains unclear how the identity of the functional groups and ligand density influence toxicity. This project will systematically explore the role of adjusting the composition, diversity and density of ligand shells in governing biocompatibility. The impact of the proposed work will be many fold. First, the products of the research will enable researchers to employ the discovered guidelines for molecular-level design as a foundation to advance materials design. The precision libraries will serve as new reference materials for the nanoEHS research community, thereby leveraging the activities of basic and applied researchers across disciplines. Society will benefit from the reduction in negative consequences of future products on health and the environment. Finally, the research team will use the integrated nature of this project to provide undergraduate and graduate students with a dynamic multidisciplinary educational experience. The co-PIs and students will communicate not only with colleagues, but also with members of the broader public. The latter goal will be achieved via hands-on and online demonstrations targeting K-12 audiences.The PIs will develop precision engineered NP libraries that are designed specifically to define the importance of the NP surface on biocompatibility. To improve the relevance and sensitivity of biocompatibility measures, they will use the high throughput multi-dimensional embryonic zebrafish system. Determining the relationship between avidity and toxicity will inform the use of the mixtures of ligands likely to appear in next generation applications.