The role of palmitoylation in hair follicle and epidermal stem cell biology

棕榈酰化在毛囊和表皮干细胞生物学中的作用

• 批准号: DP0878823
• 负责人: Prof Ian Smyth
• 金额: $ 16.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-02 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878823
• 关键词: role; palmitoylation; hair; follicle; epidermal

A proteins activity can be shaped by sugar, phosphate and lipid modifications. This proposal will investigate the effects of the lipid modification called palmitoylation, about which we know very little. Our preliminary experiments suggest that palmitoylation is crucial for normal skin biology. We will explore its effects on the biology of the proteins which are modified, the cells in which they are found and the tissues in which they reside. Understanding more about these modifications will help us to learn more about the biology of our skin and will help us to understand diseases which affect our largest organ.

A蛋白的活性可以通过糖、磷酸盐和脂质修饰来形成。这项提议将研究被称为棕榈酰化的脂质修饰的影响，我们对此知之甚少。我们的初步实验表明棕榈酰化对正常皮肤生物学至关重要。我们将探讨它对被修饰的蛋白质、它们所在的细胞和它们所在的组织的生物学影响。更多地了解这些变化将有助于我们更多地了解我们皮肤的生物学，并有助于我们了解影响我们最大器官的疾病。