Morphological development of the kidney – a paradigm for organogenesis.

肾脏的形态发育——器官发生的范例。

• 批准号: DP160103100
• 负责人: Prof Ian Smyth
• 金额: $ 34.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103100
• 关键词: Morphological; development; kidney; paradigm; organogenesis.

This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.

该项目旨在揭示肾脏如何发育，正常成人功能如何建立以及先天性肾脏畸形如何发生。它的目的是研究一个数学模式，已经发现在程序分支形态发生决定肾脏发育。通过结合尖端的遗传方法、形态学分析和数学模型，该项目计划探索这种模式是如何建立的，它是如何决定肾脏发育的，以及它是否构成了器官形成的一个古老的核心机制。项目成果可增进对基本发育过程和发育疾病及变异的理解。项目发现对于理解其他器官系统的发育也很重要。