A knockout approach to identifying genes involved in epidermal development and homeostasis

识别参与表皮发育和稳态的基因的敲除方法

• 批准号: DP1092723
• 负责人: Prof Ian Smyth
• 金额: $ 23.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092723
• 关键词: knockout; approach; identifying; genes; involved

These studies will identify new genes which play a role in the development or maintenance of the skin, some of which may subsequently be shown to play a role in disease. The project capitalises on an investment of tens of millions of dollars by the Wellcome Trust in generating a significant cohort of knockout mice. Our involvement in this international initiative will ensure Australia's participation in a project at the forefront of mouse genetics, using cutting edge infrastructure and technologies to provide insights into the complement of genes involved in skin biology. Models of interest will be repatriated to Australia for further study capitalising on existing infrastructure provided through the NCRIS funding program.

这些研究将确定在皮肤发育或维护中发挥作用的新基因，其中一些可能随后被证明在疾病中发挥作用。 该项目利用了Wellcome Trust投资的数千万美元，用于产生大量基因敲除小鼠。 我们参与这一国际倡议将确保澳大利亚参与小鼠遗传学前沿的项目，利用尖端的基础设施和技术，深入了解皮肤生物学所涉及的基因的补充。感兴趣的模型将被遣返到澳大利亚进行进一步的研究，利用通过NCRIS资助计划提供的现有基础设施。