MRI: Acquisition of Mass Spectrometry Technology for Research and Training

太平洋大学被授予通过获得质谱仪技术进行蛋白质组学研究的奖项。这项研究整合了全面的指导计划、研讨会，并为寻求科学和工程职业以及与健康相关的职业的学生提供培训。该仪器将为调查人员提供机会，培训学生在广泛的教育层次，包括高中，本科生和研究生水平。通过实施课程补充，遗传学和分子生物学技术课程中的实践蛋白质组活动将为学生提供强大的机会，学习如何结合基因组和蛋白质组方法来解决科学问题。此外，针对当地高中的外展活动将使学生能够用玻璃棒从环境中收集蜘蛛网，用水清洗纤维，并学习如何使用质谱学来识别现实生活材料中的生物分子。调查人员还将通过SEED(教育和经济发展奖学金)项目鼓励经济困难和少数族裔高中生参与，促进代表人数不足的群体的参与。该工具对学生学习和STEM教育的影响将通过电子评估前和评估后问卷进行评估。研究结果将提高社区成员的科学素养，突出材料开发和保护生物学的重要概念。该研究项目的活动具有创新性和前沿性，涉及跨越生物、化学、生物化学、生物工程和健康科学的专业知识。这些科学研究将促进我们对控制蜘蛛丝组装的分子机制的了解，从而为工业和商业应用的合成纤维生产带来新的战略。它还将提供对类似蛋白质活性部位的生物聚合物的化学性质的洞察，以及控制脊椎动物细胞运动和发育过程的机制。此外，它还将识别调节真核细胞中蛋白质分泌的新因素，为蛋白质化学家提供使重组蛋白质表达系统更强大的新方法。最后，他们将阐明调节人类毒素新陈代谢的成分，识别导致人类癌症形成的致病因素，并为生物学中重要的进化和环境问题提供答案。作为一个集体，这些研究将对学生、教师和社区产生极大的变革，导致工程和纳米技术新生物材料的开发，为学术界和工业界提供更好的重组蛋白表达方法，增加对细胞迁移机制的理解，并将知识进步到进化和保护生物学的基本主题。

An award is made to the University of the Pacific to do proteomics research through the acquisition of mass spectrometry technology. The research integrates comprehensive mentoring programs, workshops, and provides training for students pursuing careers in science and engineering, as well as health-related professions. The instrumentation will provide investigators with the opportunity to train students across a broad range of educational tiers, including high school, undergraduate and graduate student levels. By implementing curricular additions, hands-on proteomic activities in genetics and molecular biological technique courses will provide students with powerful opportunities to learn how to combine genomic and proteomic approaches to solve scientific questions. Additionally, outreach activities that target local high schools, will enable students to collect cobwebs from the environment with glass rods, wash the fibers with water, and learn how to use mass spectrometry to identify biomolecules in real-life materials. Investigators will also promote the engagement of underrepresented groups by encouraging economically disadvantaged and minority high school student participation through Project SEED (Scholarships for Education and Economic Development). The impact of the instrumentation on student learning and STEM education will be assessed by electronic pre- and post-assessment questionnaires. Results from the research will enhance scientific literacy for members in the community, highlighting important concepts in materials development as well as conservational biology. Activities of the research project are innovative and cutting-edge, involving expertise that spans biology, chemistry, biochemistry, bioengineering, and the health sciences. These scientific investigations will advance our knowledge on the molecular mechanisms that govern spider silk assembly, leading to new strategies for synthetic fiber production for industrial and commercial applications. It will also provide insight into the chemical properties of biopolymers resembling the active sites of proteins as well as the machinery governing cell movement and developmental processes in vertebrates. Additionally, it will identify novel factors that regulate protein secretion in eukaryotic cells, providing protein chemist with new approaches to make recombinant protein expression systems more robust. Lastly, they will elucidate constituents that modulate the metabolism of human toxins, identify pathogenic factors that contribute to human cancer formation, and provide answers to important evolutionary and environmental questions in biology. As a collective unit, these studies will be highly transformative for students, faculty, and the community, leading to the development of new biomaterials for engineering and nanotechnology, better methods for recombinant protein expression for academia and industry, increased comprehension with cellular migration mechanisms, and advances in knowledge to fundamental themes in evolution and conservation biology.