MRI: Acquisition of Mass Spectrometry Technology for Research and Training

向太平洋大学颁发了一个奖项，通过获得质谱技术进行蛋白质组学研究。该研究整合了全面的辅导计划，研讨会，并为追求科学和工程职业以及健康相关专业的学生提供培训。仪器将为调查人员提供机会，培训学生跨越广泛的教育层次，包括高中，本科和研究生水平。通过实施课程增加，动手蛋白质组学活动在遗传学和分子生物学技术课程将为学生提供强大的机会，学习如何联合收割机基因组和蛋白质组学的方法来解决科学问题。此外，针对当地高中的外展活动将使学生能够用玻璃棒从环境中收集蜘蛛网，用水清洗纤维，并学习如何使用质谱法识别现实生活中的生物分子。调查人员还将通过鼓励经济弱势群体和少数民族高中生通过项目SEED（教育和经济发展奖学金）参与，促进代表性不足的群体的参与。仪器对学生学习和STEM教育的影响将通过电子评估前和评估后问卷进行评估。研究结果将提高社区成员的科学素养，突出材料开发和保护生物学的重要概念。该研究项目的活动是创新和前沿的，涉及生物学，化学，生物化学，生物工程和健康科学的专业知识。这些科学研究将推进我们对控制蜘蛛丝组装的分子机制的了解，从而为工业和商业应用的合成纤维生产带来新的策略。它还将提供深入了解类似蛋白质活性位点的生物聚合物的化学性质以及脊椎动物中控制细胞运动和发育过程的机制。 此外，它将确定调节真核细胞中蛋白质分泌的新因子，为蛋白质化学家提供新方法，使重组蛋白表达系统更加强大。最后，他们将阐明调节人类毒素代谢的成分，确定导致人类癌症形成的致病因素，并为生物学中重要的进化和环境问题提供答案。作为一个集体单位，这些研究将是高度变革的学生，教师和社区，导致新的生物材料的工程和纳米技术的发展，更好的方法为学术界和工业界重组蛋白表达，增加理解与细胞迁移机制，并在进化和保护生物学的基本主题知识的进步。

An award is made to the University of the Pacific to do proteomics research through the acquisition of mass spectrometry technology. The research integrates comprehensive mentoring programs, workshops, and provides training for students pursuing careers in science and engineering, as well as health-related professions. The instrumentation will provide investigators with the opportunity to train students across a broad range of educational tiers, including high school, undergraduate and graduate student levels. By implementing curricular additions, hands-on proteomic activities in genetics and molecular biological technique courses will provide students with powerful opportunities to learn how to combine genomic and proteomic approaches to solve scientific questions. Additionally, outreach activities that target local high schools, will enable students to collect cobwebs from the environment with glass rods, wash the fibers with water, and learn how to use mass spectrometry to identify biomolecules in real-life materials. Investigators will also promote the engagement of underrepresented groups by encouraging economically disadvantaged and minority high school student participation through Project SEED (Scholarships for Education and Economic Development). The impact of the instrumentation on student learning and STEM education will be assessed by electronic pre- and post-assessment questionnaires. Results from the research will enhance scientific literacy for members in the community, highlighting important concepts in materials development as well as conservational biology. Activities of the research project are innovative and cutting-edge, involving expertise that spans biology, chemistry, biochemistry, bioengineering, and the health sciences. These scientific investigations will advance our knowledge on the molecular mechanisms that govern spider silk assembly, leading to new strategies for synthetic fiber production for industrial and commercial applications. It will also provide insight into the chemical properties of biopolymers resembling the active sites of proteins as well as the machinery governing cell movement and developmental processes in vertebrates. Additionally, it will identify novel factors that regulate protein secretion in eukaryotic cells, providing protein chemist with new approaches to make recombinant protein expression systems more robust. Lastly, they will elucidate constituents that modulate the metabolism of human toxins, identify pathogenic factors that contribute to human cancer formation, and provide answers to important evolutionary and environmental questions in biology. As a collective unit, these studies will be highly transformative for students, faculty, and the community, leading to the development of new biomaterials for engineering and nanotechnology, better methods for recombinant protein expression for academia and industry, increased comprehension with cellular migration mechanisms, and advances in knowledge to fundamental themes in evolution and conservation biology.