MRI: Acquisition of 400 MHz NMR Spectrometer with Solid State Capabilities to Serve the Region Surrounding Memphis

MRI：采购具有固态功能的 400 MHz NMR 波谱仪，为孟菲斯周边地区提供服务

• 批准号: 1531466
• 负责人: Theodore Burkey
• 金额: $ 33.96万
• 依托单位: University of Memphis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531466&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Theodore Burkey from the University of Memphis (UM) and colleagues Tomoko Fujiwara, Daniel Baker and Xuan Zhao will acquire a 400 MHz NMR spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance. The instrument also allows study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate and graduate students. Seven faculty members at UM serve as research project leaders comprising the primary user team. The NMR increases productivity, enables new areas of investigation, and enhances UM as a regional resource for industry. Since the NMR solids capability is not available in the region it has become a resource for regional research-intensive institutions including the University of Mississippi. The automatic sample changer along with internet connectivity allows real experimental results to be integrated in lab curricula for UM and local four-year colleges.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) studying cancer phototherapy using multifunctional nanocomplexes; (b) studying chemical modification of smart chitosan implants; (c) analyzing chain exchange kinetics and mechanism of tri-block copolymer micelles during sol-to-gel transitions; (d) investigating functional nanoporous membranes; (e) designing of metal complexes for catalytic splitting of water; (f) developing sub-picosecond photoresponsive organometallics; (g) investigating halogen bond-driven assemblies in pi-conjugated oligomers for materials applications; (h) designing sphingosine kinase and diacylglycerol kinase assays; and (i) studying autotaxin inhibitor optimization.

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，孟菲斯大学(UM)的西奥多·伯基教授及其同事藤原智子、丹尼尔·贝克和赵轩将获得一台具有固态能力的400 MHz核磁共振波谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域。该仪器还可以研究与生物相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。相对于标准的核磁共振探头，低温探头的灵敏度显著提高。这些核磁共振研究的结果对合成有机/无机化学、材料化学和生物化学都有影响。该仪器是本科生和研究生进行的教学和研究的一个组成部分。密歇根大学的七名教员担任研究项目负责人，组成主要用户团队。核磁共振提高了生产率，使新的研究领域成为可能，并加强了密歇根大学作为地区性工业资源的地位。由于核磁共振固体能力在该地区不可用，它已成为包括密西西比大学在内的区域研究密集型机构的资源。自动换样器和互联网连接使真实的实验结果能够被整合到密歇根大学和当地四年制大学的实验室课程中。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)利用多功能纳米络合物研究癌症光疗法；(B)研究智能壳聚糖植入物的化学修饰；(C)分析三嵌段共聚物胶束在溶胶-凝胶转变过程中的链交换动力学和机理；(D)研究功能纳米孔膜；(E)设计用于催化分解水的金属络合物；(F)开发亚皮秒光响应性金属；(G)研究材料应用中pi-共轭低聚物中卤键驱动的组装体；(H)设计鞘氨醇激酶和二酰甘油激酶分析；以及(I)研究自体趋化蛋白抑制剂的优化。