MRI: Acquisition of 400 MHz NMR Spectrometer with Solid State Capabilities to Serve the Region Surrounding Memphis

在重大研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持下，孟菲斯大学（UM）的西奥多·伯基教授及其同事Tomoko Fujiwara、丹尼尔·贝克和赵璇将获得一台具有固态功能的400 MHz NMR光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应。 该仪器还允许研究生物学相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。相对于标准NMR探针，低温探针提供了灵敏度的显著增加。这些NMR研究的结果对合成有机/无机化学、材料化学和生物化学产生了影响。该仪器是本科生和研究生进行教学和研究的一个组成部分。七名教师在UM担任研究项目负责人组成的主要用户团队。NMR提高了生产力，使新的调查领域，并提高了UM作为工业区域资源的地位。由于该地区没有核磁共振固体能力，它已成为包括密西西比大学在内的区域研究密集型机构的资源。自动进样器沿着和互联网连接，可将真实的实验结果纳入澳大和本地四年制大学的实验室课程。该奖项旨在加强各级研究和教育，特别是在以下领域：（a）研究使用多功能纳米复合物的癌症光疗;（B）研究智能壳聚糖植入物的化学改性;（c）研究使用纳米复合物的癌症光疗;（d）研究使用纳米复合物的癌症光疗;（e）研究使用纳米复合物的（c）分析三嵌段共聚物胶束在溶胶-凝胶转变过程中的链交换动力学和机理;（d）研究功能性纳米多孔膜;（e）设计用于催化分解水的金属配合物;（f）开发亚皮秒光响应有机金属化合物;（g）研究用于材料应用的π-缀合的寡聚物中的卤素键驱动的组装;（h）设计鞘氨醇激酶和二酰基甘油激酶测定;以及（i）研究自分泌运动因子抑制剂优化。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Theodore Burkey from the University of Memphis (UM) and colleagues Tomoko Fujiwara, Daniel Baker and Xuan Zhao will acquire a 400 MHz NMR spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance. The instrument also allows study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate and graduate students. Seven faculty members at UM serve as research project leaders comprising the primary user team. The NMR increases productivity, enables new areas of investigation, and enhances UM as a regional resource for industry. Since the NMR solids capability is not available in the region it has become a resource for regional research-intensive institutions including the University of Mississippi. The automatic sample changer along with internet connectivity allows real experimental results to be integrated in lab curricula for UM and local four-year colleges.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) studying cancer phototherapy using multifunctional nanocomplexes; (b) studying chemical modification of smart chitosan implants; (c) analyzing chain exchange kinetics and mechanism of tri-block copolymer micelles during sol-to-gel transitions; (d) investigating functional nanoporous membranes; (e) designing of metal complexes for catalytic splitting of water; (f) developing sub-picosecond photoresponsive organometallics; (g) investigating halogen bond-driven assemblies in pi-conjugated oligomers for materials applications; (h) designing sphingosine kinase and diacylglycerol kinase assays; and (i) studying autotaxin inhibitor optimization.