MRI: Acquisition of Combined Spinning Disc Confocal/Atomic Force Microscopy System

MRI:获得组合旋转圆盘共焦/原子力显微镜系统

基本信息

  • 批准号:
    1531921
  • 负责人:
  • 金额:
    $ 63.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-15 至 2018-07-31
  • 项目状态:
    已结题

项目摘要

An award is made to Colorado State University (CSU) to acquire a microscopy system that combines multiple techniques in a single platform. This instrument will be housed in a facility that enables secure 24-hour access for users and will be maintained by a staff scientist. The instrument will be included in a new module for an undergraduate lab course that serves about 100 students annually. Students in a graduate course on microscopy will also be introduced to the instrument. The instrument will be made available to a broad user base both inside and outside of CSU, by including it in a Microscopy Imaging Network (MIN). This network has a pilot grant program for new instrument users. These pilot grants support user training and preliminary data acquisition on this and other microscopy instruments at CSU. The instrument will combine scanning probe and optical techniques. The scanning probe techniques enable imaging of the topographical features and mechanical properties of samples at very high resolution. The optical techniques include spinning disc confocal microscopy, fluorescence recovery after photobleaching (FRAP), and photoactivation (PA). The instrument will be configured to perform imaging of wet samples including live cells. Combining these fundamentally different yet complementary techniques on a single platform enables interrogation of multiple sample properties simultaneously and in the exact same field of view. Therefore specific measurements made with one technique (e.g. mechanical properties) can be correlated with features (e.g. location of chemical functional groups or biological structures) measured by another technique. Changes in these correlations and spatial organization can be monitored over time to observe biological phenomena. The initial user group consists of 19 investigators in ten academic departments from three universities (CSU, University of Colorado at Denver, and University of Denver). These investigators will use the instrument for interdisciplinary and collaborative research projects including biochemical and biophysical studies and for the development of new materials for biomedical and tissue engineering applications.
授予科罗拉多州立大学(CSU)一个奖项,以获得一个显微镜系统,在一个单一的平台结合多种技术。该仪器将存放在一个设施中,用户可以24小时安全访问,并将由一名科学家进行维护。该仪器将被纳入本科实验室课程的新模块,每年为约100名学生提供服务。在显微镜研究生课程的学生也将介绍该仪器。该仪器将通过将其纳入显微镜成像网络(MIN),提供给CSU内外的广泛用户群。该网络有一个针对新仪器用户的试点赠款计划。这些试点赠款支持用户培训和初步数据采集在CSU的这种和其他显微镜仪器。 该仪器将联合收割机扫描探头和光学技术相结合。扫描探针技术能够以非常高的分辨率对样本的地形特征和机械性能进行成像。光学技术包括旋转圆盘共聚焦显微镜、光漂白后荧光恢复(FRAP)和光活化(PA)。该仪器将被配置为对包括活细胞在内的湿样本进行成像。将这些根本不同但互补的技术结合在一个平台上,可以在完全相同的视场中同时询问多个样品的特性。因此,用一种技术进行的特定测量(例如机械性能)可以与用另一种技术测量的特征(例如化学官能团或生物结构的位置)相关联。这些相关性和空间组织的变化可以随着时间的推移进行监测,以观察生物现象。最初的用户组由来自三所大学(科罗拉多州立大学、丹佛的科罗拉多大学和丹佛大学)的10个学术部门的19名调查人员组成。这些研究人员将使用该仪器进行跨学科和合作研究项目,包括生物化学和生物物理研究,以及开发用于生物医学和组织工程应用的新材料。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Matthew Kipper其他文献

Matthew Kipper的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Matthew Kipper', 18)}}的其他基金

Modified carrageenan-based nanomaterials as sustainable, immunomodulatory, hemocompatible, and antibactieral biomaterials
改性卡拉胶纳米材料作为可持续、免疫调节、血液相容性和抗菌生物材料
  • 批准号:
    2313878
  • 财政年份:
    2023
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Continuing Grant
Condensed tannin polymers as a new functional biomaterials
缩合单宁聚合物作为新型功能性生物材料
  • 批准号:
    2306983
  • 财政年份:
    2023
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
Collaborative Research: Protein nanofiber growth factor delivery platforms for modulating phenotype of iPSC-derived human hepatocytes and liver non-parenchymal cells
合作研究:用于调节 iPSC 衍生的人肝细胞和肝脏非实质细胞表型的蛋白质纳米纤维生长因子递送平台
  • 批准号:
    1933552
  • 财政年份:
    2019
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
Tuning Interfacial Biomolecule Interactions with Massively Parallel Nanopore Arrays
使用大规模并行纳米孔阵列调节界面生物分子相互作用
  • 批准号:
    1704901
  • 财政年份:
    2017
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
UNS: Understanding protein adsorption in polysaccaride brushes
UNS:了解多糖刷中的蛋白质吸附
  • 批准号:
    1511830
  • 财政年份:
    2015
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
CAREER: Development of Complex Polysaccharide Nanostructures via Electrostatic Self-Assembly
职业:通过静电自组装开发复杂的多糖纳米结构
  • 批准号:
    0847641
  • 财政年份:
    2009
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant

相似海外基金

MRI: Acquisition of a Scanning Near-Field Optical Microscope (neaSNOM) with Combined Nano-Infrared/Tip-Enhanced Raman Spectroscopy for Research & Education
MRI:购买扫描近场光学显微镜 (neaSNOM) 并结合纳米红外/尖端增强拉曼光谱进行研究
  • 批准号:
    2216239
  • 财政年份:
    2022
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI: Acquisition of a Combined AFM and Fluorescence Microscopy System
MRI:获得 AFM 和荧光显微镜组合系统
  • 批准号:
    1337586
  • 财政年份:
    2013
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI Acquisition: An integrated platform for combined multi-scale mechanical and chemical analysis to inform functional materials design
MRI 采集:结合多尺度机械和化学分析的集成平台,为功能材料设计提供信息
  • 批准号:
    1338154
  • 财政年份:
    2013
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI: Acquisition of a Combined X-ray Photoelectron Spectrometer and Scanning Auger Microprobe
MRI:获取组合 X 射线光电子能谱仪和扫描俄歇微探针
  • 批准号:
    1338173
  • 财政年份:
    2013
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI Data
用于同时采集 PET/MRI 数据的组合 MRI/PET 成像仪
  • 批准号:
    7125804
  • 财政年份:
    2007
  • 资助金额:
    $ 63.9万
  • 项目类别:
MRI: Acquisition of Cryogenic UHV Facilities for a Combined ARPES-STM System for Research and Education of Novel Materials
MRI:为新材料研究和教育的组合 ARPES-STM 系统采购低温特高压设施
  • 批准号:
    0421017
  • 财政年份:
    2004
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI: Phase I of an Advanced Spectromicroscopy Facility: Acquisition of a Combined Confocal Optical and Atomic Force Microscope, and an Enhanced FTIR Imaging Microscope
MRI:先进光谱显微镜设施的第一阶段:购买组合式共焦光学和原子力显微镜以及增强型 FTIR 成像显微镜
  • 批准号:
    0421521
  • 财政年份:
    2004
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI: Acquisition of a Combined Raman and Infrared Microscope with Nano-scale Spatial Resolution
MRI:获取具有纳米级空间分辨率的拉曼和红外显微镜组合
  • 批准号:
    0421409
  • 财政年份:
    2004
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
MRI: Acquisition and Construction of a Combined X-Band/Q-Band CW EPR/ENDOR Spectrometer
MRI:X 波段/Q 波段组合 CW EPR/ENDOR 光谱仪的采集和构建
  • 批准号:
    0216277
  • 财政年份:
    2002
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Continuing Grant
MRI: Acquisition of a Combined GC and HPLC System for Undergraduate Research and Training
MRI:获取用于本科生研究和培训的组合 GC 和 HPLC 系统
  • 批准号:
    0115905
  • 财政年份:
    2001
  • 资助金额:
    $ 63.9万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了