NSF/FDA Scholar-in-Residence at FDA: Understanding the Bioactivity and Safety of Metal and Metal Oxide Nanoparticles Used in Medical Devices

PI：聂志宏 提案编号：1541654 活性氧（ROS）的产生被认为是医疗器械中常用的金属和金属氧化物纳米颗粒（NP）产生细胞毒性的最重要原因之一。该项目建议使用电子自旋共振光谱来评估与纳米颗粒相关的潜在毒性。它旨在获得有关纳米颗粒毒性的新见解和机理知识。拟议的研究将满足识别医疗器械中使用的金属和金属氧化物纳米颗粒潜在危害的迫切需要。该项目有三个预期成果。首先，这些研究将为从根本上理解纳米材料产生 ROS 提供新的见解。其次，它将首次全面阐明纳米粒子的空间排列对其在生物相关环境中ROS生成的作用。最后，从这项研究中获得的机械知识将指导更好地设计安全有效的含有纳米材料的医疗器械或产品。 PI 将招募和培训学生，特别是研究生和本科生中代表性不足的群体的学生，加入该研究项目。参与多学科研究的学生将获得纳米材料、光谱学、纳米生物相互作用和医疗安全方面的技能和知识。

PI: Nie, Zhihong Proposal Number: 1541654 The production of reactive oxygen species (ROS) is known as one of the most important reasons for the cytotoxicity of metal and metal oxide nanoparticles (NPs) that are commonly used in medical devices. This project proposes to use electron spin resonance spectroscopy to assess potential toxicity associated with nanoparticles. It aims for new insights and mechanistic knowledge regarding nanoparticle toxicity.The proposed research will meet the pressing need for identifying the potential hazards of metal and metal oxide NPs used in medical devices. The project has three expected outcomes. First, these studies will offer new insights into the fundamental understanding the ROS generation by nanomaterials in general. Second, it will, for the first time, fully elucidate the role of spatial arrangement of NPs on their ROS generation in biologically relevant environments. Finally, the mechanistic knowledge obtained from this research will guide the better design of safe and effective medical devices or products containing nanoscale materials. The PI will recruit and train students particularly from under-represented groups at both graduate and undergraduate levels into this research program. Students involved in the multidisciplinary research will acquire skills and knowledge crossing in nanomaterials, spectroscopy, nano-bio interactions, and medical safety.