NSF/FDA Scholar-in-Residence at FDA: Transport in Polymeric Materials used in Biomedical Devices

1041361 Elab PI建议使用时间分辨傅里叶变换红外衰减全反射（FTIR-ATR）光谱法研究生物医学设备中使用的聚合物中液体的传输。该技术的独特之处在于，它是一种非侵入性的原位方法，该方法是稳健的、准确的，并且可以在液体/聚合物系统中提供可靠的早期数据。水、药物替代物）和聚合物，因为两者的整个中红外光谱作为时间的函数在原位测量。这允许探索扩散剂/聚合物系统中的分子变化（例如，多组分扩散、聚合物弛豫），以及量化扩散剂和聚合物之间的分子相互作用的能力。使用这种技术是一个未开发的领域，用于生物医学设备中使用的聚合物的运输。该研究项目的成果将提供对分子水平传输机制的基本理解，并提供生物医学设备科学的新知识体系。

1041361ElabdThe PI proposes to investigate the transport of liquids in polymers used in biomedical devices with time-resolved Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy. This technique is unique in that it is a non-invasive, in situ method that is robust, accurate, and can provide reliable early-time data in liquid/polymer systems.Additionally, time-resolved FTIR-ATR spectroscopy provides molecular-level contrast between diffusant(s) (e.g., water, drug surrogates) and the polymer as the entire mid-infrared spectrum of both are measured in situ as a function of time. This allows for the exploration of molecular changes in the diffusant/polymer system (e.g., multicomponent diffusion, polymer relaxation), and the ability to quantify molecular interactions between diffusants and polymer. Using this technique is an unexplored area for transport in polymers used in biomedical devices. The outcomes of this research project will provide a fundamental understanding of molecular level transport mechanisms and provide a new body of knowledge in biomedical device science.