NSF/FDA Scholar in Residence Program on Characterization of Micro- and Nanostructured Titanium Oxide and Zirconium Oxide Surfaces for Improved Medical Implants

摘要利用石英晶体微天平技术，采用标准蛋白质分析和分析技术，定性和定量评价蛋白质吸附动力学。这些研究中获得的信息将作为材料特性-生物性能数据库的基础，其中将考虑体外细胞-材料相互作用、蛋白质吸附和工艺参数之间的关联。该数据库将对FDA-CDRH中与具有钛氧化物或氧化锆表面的设备相关的监管决策具有基本价值。这一研究和教育计划非常适合常驻学者计划的目标，因为它结合了北卡罗来纳大学/NCSU生物医学工程系的纳米材料处理能力和CDRH的体外生物表征能力。该项目将包括研究生和在FDA白橡树园区的PI活动，为期两年。

Abstract#1343533Roger J. NarayanStandard protein assays and analyses involving quartz crystal microbalance technology will be employed to qualitatively and quantitatively assess protein adsorption dynamics. The information obtained in these studies will serve as the basis for a material property-biological performance database, in which the associations among in vitro cell-material interaction, protein adsorption, and processing parameters will be considered. The database will be of fundamental value for regulatory decision-making in FDA-CDRH related to devices with titanium oxide or zirconium oxide surfaces. This research and education program is well-suited to goals of the Scholar-in-Residence program because it combines nanomaterials processing capabilities at the UNC/NCSU Department of BiomedicalEngineering with in vitro biological characterization capabilities at the CDRH. This program will involve graduate student and PI activities at the FDA White Oak campus over a two-year period.