NSF/FDA Scholar in Residence Program on Characterization of Micro- and Nanostructured Titanium Oxide and Zirconium Oxide Surfaces for Improved Medical Implants

摘要#1343533Roger J. Narayan将采用涉及石英晶体微量天平技术的标准蛋白质测定和分析来定性和定量评估蛋白质吸附动力学。这些研究中获得的信息将作为材料特性-生物性能数据库的基础，其中将考虑体外细胞-材料相互作用、蛋白质吸附和工艺参数之间的关联。该数据库将对FDA-CDRH中与氧化钛或氧化锆表面器械相关的监管决策具有基本价值。这项研究和教育计划非常适合于奖学金驻校计划的目标，因为它结合了生物医学工程部/NCSU的纳米材料处理能力和CDRH的体外生物表征能力。该计划将涉及研究生和PI活动在FDA白色橡树校园超过两年的时间。

Abstract#1343533Roger J. NarayanStandard protein assays and analyses involving quartz crystal microbalance technology will be employed to qualitatively and quantitatively assess protein adsorption dynamics. The information obtained in these studies will serve as the basis for a material property-biological performance database, in which the associations among in vitro cell-material interaction, protein adsorption, and processing parameters will be considered. The database will be of fundamental value for regulatory decision-making in FDA-CDRH related to devices with titanium oxide or zirconium oxide surfaces. This research and education program is well-suited to goals of the Scholar-in-Residence program because it combines nanomaterials processing capabilities at the UNC/NCSU Department of BiomedicalEngineering with in vitro biological characterization capabilities at the CDRH. This program will involve graduate student and PI activities at the FDA White Oak campus over a two-year period.